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F<jats:sc>e<\/jats:sc><jats:sub>NO<\/jats:sub> provides us with valuable, additional information regarding the nature of underlying airway inflammation, and complements lung function testing and measurement of airway hyper\u2010reactivity. This review focuses on clinical applications of F<jats:sc>e<\/jats:sc><jats:sub>NO<\/jats:sub> in paediatric asthma. First, F<jats:sc>e<\/jats:sc><jats:sub>NO<\/jats:sub> provides us with a practical tool to aid in the diagnosis of asthma and distinguish patients who will benefit from inhaled corticosteroids from those who will not. Second, F<jats:sc>e<\/jats:sc><jats:sub>NO<\/jats:sub> is helpful in predicting exacerbations, and predicting successful steroid reduction or withdrawal. In atopic asthmatic children F<jats:sc>e<\/jats:sc><jats:sub>NO<\/jats:sub> is beneficial in adjusting steroid doses, discerning those patients who require additional therapy from those whose medication dose could feasibly be reduced. In pre\u2010school children F<jats:sc>e<\/jats:sc><jats:sub>NO<\/jats:sub> may be of help in the differential diagnosis of respiratory symptoms, and may potentially allow for better targeting and monitoring of anti\u2010inflammatory treatment.<\/jats:p>","DOI":"10.1111\/j.1365-2222.2007.02897.x","type":"journal-article","created":{"date-parts":[[2010,8,3]],"date-time":"2010-08-03T00:26:31Z","timestamp":1280795191000},"page":"246-259","source":"Crossref","is-referenced-by-count":133,"title":["Exhaled nitric oxide in childhood asthma: a review"],"prefix":"10.1111","volume":"38","author":[{"given":"M. W. H.","family":"Pijnenburg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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