{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T03:20:57Z","timestamp":1773458457020,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2008,5,8]],"date-time":"2008-05-08T00:00:00Z","timestamp":1210204800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2008,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background\n\t\t\t\t\t<\/jats:bold> A decrease in nasal nitric oxide (NO) and an increase in exhaled NO have been demonstrated in patients with nasal polyposis (NP).<\/jats:p><jats:p><jats:bold>Objectives\n\t\t\t\t\t<\/jats:bold> The aims were to evaluate the flux of NO from the three compartments of the respiratory tract, namely, upper nasal, lower conducting and distal airways, and to search for relationships between NO parameters and indexes of upper and lower disease activity (bronchial reactivity and obstruction). The effect of medical treatment of polyposis was also evaluated.<\/jats:p><jats:p><jats:bold>Methods\n\t\t\t\t\t<\/jats:bold> Seventy patients with polyposis were recruited. At baseline, pulmonary function tests (spirometry, plethysmography, bronchomotor response to deep inspiration using forced oscillation measurement of resistance of respiratory system, methacholine challenge, multiple flow rates of exhaled NO and nasal NO measurements) were performed together with an assessment of polyposis [clinical, endoscopic and computed tomography (CT) scores].<\/jats:p><jats:p><jats:bold>Results\n\t\t\t\t\t<\/jats:bold> Statistical relationships were demonstrated between nasal NO flux and severity scores (clinical: \u03c1=\u22120.31, <jats:italic>P<\/jats:italic>=0.015; endoscopic: \u03c1=\u22120.57, <jats:italic>P<\/jats:italic>&lt;0.0001; CT: \u03c1=\u22120.46, <jats:italic>P<\/jats:italic>=0.0005), and between alveolar NO concentration and distal airflow limitation (FEF<jats:sub>25\u201375<\/jats:sub>, \u03c1=\u22120.32, <jats:italic>P<\/jats:italic>=0.011). Thirty\u2010six patients were assessed after 11 [7\u201313] (median [interquartile]) months of medical treatment, demonstrating an improvement in clinical and endoscopic scores, an increase in nasal NO flux, a decrease in NO flux from conducting airways, an improvement in the mild airflow limitation (forced expiratory volume in 1\u2003s, FEF<jats:sub>25\u201375<\/jats:sub>, even in non\u2010asthmatic patients) and a decrease in the bronchoconstrictor effect of deep inspiration.<\/jats:p><jats:p><jats:bold>Conclusions\n\t\t\t\t\t<\/jats:bold> The medical treatment of NP improves both airway reactivity and obstruction, whatever the presence of asthma, suggesting a functional link between upper and lower airway functions.<\/jats:p>","DOI":"10.1111\/j.1365-2222.2008.03006.x","type":"journal-article","created":{"date-parts":[[2008,5,9]],"date-time":"2008-05-09T02:35:50Z","timestamp":1210300550000},"page":"1140-1147","source":"Crossref","is-referenced-by-count":39,"title":["Nitric oxide evaluation in upper and lower respiratory tracts in nasal polyposis"],"prefix":"10.1111","volume":"38","author":[{"given":"C.","family":"Delclaux","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Malinvaud","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Chevalier\u2010Bidaud","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Callens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Mahut","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Bonfils","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,7,8]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3003.1999.13b15.x"},{"key":"e_1_2_6_3_2","first-page":"234","article-title":"Analysis of nasal and exhaled nitric oxide concentration in nasal polyposis","volume":"119","author":"Gilain L","year":"2002","journal-title":"Ann Otolaryngol Chir Cervicofac"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2006.01044.x"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1159\/000079168"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2005.10.005"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.165.3.2107017"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.127.5.1696"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2003.10.038"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1080\/00016480500504226"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1080\/00016480310016938"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.161.2.9905075"},{"key":"e_1_2_6_13_2","first-page":"273","article-title":"Airway obstruction in asthma","volume":"2","author":"Fredberg JJ.","year":"2001","journal-title":"does the response to a deep inspiration matter?"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.2603003"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200304000-00019"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200406-710ST"},{"key":"e_1_2_6_17_2","first-page":"61","article-title":"Aspiration flow optimized for nasal nitric oxide measurement","volume":"37","author":"Qian W","year":"1999","journal-title":"Rhinology"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.20329"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.2500\/105065899781367528"},{"key":"e_1_2_6_20_2","first-page":"586","article-title":"Nitric oxide in chronic airway inflammation in children","volume":"57","author":"Narang I","year":"2002","journal-title":"diagnostic use and pathophysiological significance"},{"key":"e_1_2_6_21_2","first-page":"1026","article-title":"The forced oscillation technique in clinical practice","volume":"22","author":"Oostveen E","year":"2003","journal-title":"methodology, recommendations and future developments"},{"key":"e_1_2_6_22_2","first-page":"278","article-title":"Effect of circadian rhythm on bronchomotor tone after deep inspiration in normal and in asthmatic subjects","volume":"132","author":"Liu YN","year":"1985","journal-title":"Am Rev Respir Dis"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00034505"},{"key":"e_1_2_6_24_2","first-page":"847","article-title":"Evaluation of the surgical treatment of nasal polyposis. 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