{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:14:02Z","timestamp":1791274442443,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2008,5,21]],"date-time":"2008-05-21T00:00:00Z","timestamp":1211328000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2008,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background\n\t\t\t\t\t<\/jats:bold> Maternal dietary avoidance of egg has been recommended to treat egg allergy in breastfed infants. However, only one of three randomized controlled trials have produced evidence in favour of this recommendation.<\/jats:p><jats:p><jats:bold>Objective\n\t\t\t\t\t<\/jats:bold> Our objective was to assess human milk ovalbumin (OVA) concentration after daily maternal ingestion of one cooked egg for 3 weeks.<\/jats:p><jats:p><jats:bold>Methods\n\t\t\t\t\t<\/jats:bold> Mothers with egg\u2010sensitive, eczematous breastfed infants were randomly allocated to consume one muffin per day containing one egg (egg group, <jats:italic>n<\/jats:italic>=16) or a similar egg\u2010free muffin (control group, <jats:italic>n<\/jats:italic>=16) for 21 days (Days 3\u201323). All mothers and infants followed an egg\u2010free diet. Breast milk samples were collected at two hourly intervals for 6\u2003h after eating the test muffins on Days 3, 12 and 23 and breast milk OVA concentration measured. Infant eczema was assessed at the commencement and completion of the trial.<\/jats:p><jats:p><jats:bold>Results\n\t\t\t\t\t<\/jats:bold> Women in the egg group had higher OVA concentrations in breast milk than the control group at all time\u2010points. Within each dietary group, OVA excretion did not change with time. OVA was not detected in breast milk of 25% of women in the egg group. In contrast, infant eczema symptom scores significantly reduced with time for both groups.<\/jats:p><jats:p><jats:bold>Conclusion\n\t\t\t\t\t<\/jats:bold> Human milk OVA is related to maternal dietary egg intake, but a significant proportion of women either have a delayed excretion or may not excrete OVA in their breast milk.<\/jats:p>","DOI":"10.1111\/j.1365-2222.2008.03014.x","type":"journal-article","created":{"date-parts":[[2008,5,21]],"date-time":"2008-05-21T13:19:11Z","timestamp":1211375951000},"page":"1186-1191","source":"Crossref","is-referenced-by-count":61,"title":["Effect of maternal egg consumption on breast milk ovalbumin concentration"],"prefix":"10.1111","volume":"38","author":[{"given":"D. J.","family":"Palmer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. S.","family":"Gold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Makrides","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,7,8]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.81.1.80"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.106.2.346"},{"key":"e_1_2_6_4_2","first-page":"221","article-title":"Egg sensitivity and eczematous manifestations in breast\u2010fed newborns with particular reference to intrauterine sensitization","volume":"35","author":"Matsumura T","year":"1975","journal-title":"Ann Allergy"},{"key":"e_1_2_6_5_2","first-page":"69","article-title":"Allergy in breast fed babies to ingredients in breast milk","volume":"42","author":"Gerrard J.","year":"1979","journal-title":"Ann Allergy"},{"key":"e_1_2_6_6_2","first-page":"361","article-title":"Passage of food antigens into circulation of breast\u2010fed infants with atopic dermatitis","volume":"61","author":"Cavagni G","year":"1988","journal-title":"Ann Allergy"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1988.tb10727.x"},{"key":"e_1_2_6_8_2","first-page":"1042","article-title":"Multiple food allergy","volume":"86","author":"De Boissieu D","year":"1997","journal-title":"a possible diagnosis in breastfed infants"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(81)92519-8"},{"key":"e_1_2_6_10_2","first-page":"268","article-title":"Cow's milk proteins cause infantile colic in breast\u2010fed infants","volume":"71","author":"Jakobsson I","year":"1983","journal-title":"a double-blind crossover study"},{"key":"e_1_2_6_11_2","first-page":"231","article-title":"Effect of maternal dietary exclusion on breast fed infants with eczema","volume":"293","author":"Cant AJ","year":"1986","journal-title":"two controlled studies"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(94)90259-3"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.291.6500.932"},{"key":"e_1_2_6_14_2","first-page":"173","article-title":"Effect of cooked and raw egg consumption on ovalbumin content of human milk","volume":"35","author":"Palmer DJ","year":"2005","journal-title":"a randomized, double-blind, cross-over trial"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.13.1746"},{"key":"e_1_2_6_16_2","first-page":"10","article-title":"Clinical validation and guidelines for the SCORAD index","volume":"195","author":"Kunz B","year":"1997","journal-title":"consensus report of the European task force on atopic dermatitis"},{"key":"e_1_2_6_17_2","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1542\/peds.111.S3.1617","article-title":"Skin manifestations of food allergy","volume":"111","author":"Burks W.","year":"2003","journal-title":"Pediatrics"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2001.03960.x"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.300.6719.230"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2000.104255"},{"key":"e_1_2_6_21_2","first-page":"76","article-title":"Treatment and prevention of food allergies in breastfed infants","volume":"61","author":"Palmer DJ","year":"2004","journal-title":"practice and evidence"}],"container-title":["Clinical &amp; Experimental Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2222.2008.03014.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2222.2008.03014.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T21:27:11Z","timestamp":1697232431000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2222.2008.03014.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,7]]},"references-count":20,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2008,7]]}},"alternative-id":["10.1111\/j.1365-2222.2008.03014.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2222.2008.03014.x","archive":["Portico"],"relation":{},"ISSN":["0954-7894","1365-2222"],"issn-type":[{"value":"0954-7894","type":"print"},{"value":"1365-2222","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,7]]}}}