{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T23:28:02Z","timestamp":1791156482694,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2008,8,13]],"date-time":"2008-08-13T00:00:00Z","timestamp":1218585600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2008,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background\n\t\t\t\t\t<\/jats:bold> ImmuBalance<jats:sup>\u2122<\/jats:sup> is a koji fungus (<jats:italic>Aspergillus oryzae<\/jats:italic>) and lactic acid fermented soybean product. This unique production process is believed to create a food supplement that helps to induce or maintain normal immune response.<\/jats:p><jats:p><jats:bold>Objective\n\t\t\t\t\t<\/jats:bold> To assess possible therapeutic effects of ImmuBalance<jats:sup>\u2122<\/jats:sup> on peanut (PN) hypersensitivity using a murine model of peanut allergy (PNA).<\/jats:p><jats:p><jats:bold>Methods\n\t\t\t\t\t<\/jats:bold> PN allergic C3H\/HeJ mice were fed standard mouse chow containing 0.5% or 1.0% ImmuBalance (ImmuBalance 2X), radiation\u2010inactivated 1.0% ImmuBalance (I\u2010ImmuBalance 2X), or regular diet chow (sham) for 4 weeks, beginning 10 weeks after the initial PN sensitization, and then challenged with PN. Anaphylactic symptom scores, plasma histamine, serum PN specific\u2010IgE levels and splenocyte cytokine profiles were determined.<\/jats:p><jats:p><jats:bold>Results\n\t\t\t\t\t<\/jats:bold> While 100% of sham\u2010treated PNA mice developed anaphylactic reactions with a median score of 3.3 following PN challenge, only 50% of ImmuBalance, 30% of ImmuBalance 2X and 40% of I\u2010ImmuBalance 2X\u2010treated mice developed allergic reactions with median scores of 1.0, 0.4 and 0.5 respectively, which were significantly less than that in the sham\u2010treated mice (<jats:italic>P<\/jats:italic>&lt;0.05). Plasma histamine and PN specific\u2010IgE levels were also significantly less in all treated mice than in sham\u2010treated mice (<jats:italic>P<\/jats:italic>&lt;0.05). Furthermore, IL\u20104, IL\u20105 and IL\u201013 production by PN\u2010stimulated splenocytes <jats:italic>in vitro<\/jats:italic> from ImmuBalance fed mice were markedly reduced compared with sham\u2010treated mice, whereas IFN\u2010\u03b3 production was moderately increased. TGF\u2010\u03b2 and TNF\u2010\u03b1 production were similar.<\/jats:p><jats:p><jats:bold>Conclusions\n\t\t\t\t\t<\/jats:bold> ImmuBalance protects against PN\u2010induced anaphylaxis when administered as a food supplement in this model. Protection was associated with down\u2010regulation of Th2 responses. This supplement may provide a potential novel therapy for PNA.<\/jats:p>","DOI":"10.1111\/j.1365-2222.2008.03075.x","type":"journal-article","created":{"date-parts":[[2008,8,14]],"date-time":"2008-08-14T01:29:17Z","timestamp":1218677357000},"page":"1808-1818","source":"Crossref","is-referenced-by-count":27,"title":["Therapeutic effects of a fermented soy product on peanut hypersensitivity is associated with modulation of T\u2010helper type 1 and T\u2010helper type 2 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