{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T10:33:06Z","timestamp":1792060386875,"version":"4.4.0"},"reference-count":28,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2009,11,13]],"date-time":"2009-11-13T00:00:00Z","timestamp":1258070400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2009,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background\n\t\t\t\t\t<\/jats:bold> Common polymorphisms have been identified in genes suspected to play a role in asthma. We investigated their associations with wheeze and allergy in a case\u2013control sample from Phase 2 of the International Study of Asthma and Allergies in Childhood.<\/jats:p><jats:p><jats:bold>Methods\n\t\t\t\t\t<\/jats:bold> We compared 1105 wheezing and 3137 non\u2010wheezing children aged 8\u201312 years from 17 study centres in 13 countries. Genotyping of 55 candidate single nucleotide polymorphisms (SNPs) in 14 genes was performed using the Sequenom System. Logistic regression models were fitted separately for each centre and each SNP. A combined per allele odds ratio and measures of heterogeneity between centres were derived by random effects meta\u2010analysis.<\/jats:p><jats:p><jats:bold>Results\n\t\t\t\t\t<\/jats:bold> Significant associations with wheeze in the past year were detected in only four genes (<jats:italic>IL4R, TLR4, MS4A2, TLR9, P<\/jats:italic>&lt;0.05), with per allele odds ratios generally &lt;1.3. Variants in <jats:italic>IL4R<\/jats:italic> and <jats:italic>TLR4<\/jats:italic> were also related to allergen\u2010specific IgE, while polymorphisms in <jats:italic>FCER1B (MS4A2)<\/jats:italic> and <jats:italic>TLR9<\/jats:italic> were not. There were also highly significant associations (<jats:italic>P<\/jats:italic>&lt;0.001) between <jats:italic>SPINK5<\/jats:italic> variants and visible eczema (but not IgE levels) and between <jats:italic>IL13<\/jats:italic> variants and total IgE. Heterogeneity of effects across centres was rare, despite differences in allele frequencies.<\/jats:p><jats:p><jats:bold>Conclusions\n\t\t\t\t\t<\/jats:bold> Despite the biological plausibility of IgE\u2010related mechanisms in asthma, very few of the tested candidates showed evidence of association with both wheeze and increased IgE levels. We were unable to confirm associations of the positional candidates <jats:italic>DPP10<\/jats:italic> and <jats:italic>PHF11<\/jats:italic> with wheeze, although our study had ample power to detect the expected associations of <jats:italic>IL13<\/jats:italic> variants with IgE and <jats:italic>SPINK5<\/jats:italic> variants with eczema.<\/jats:p>","DOI":"10.1111\/j.1365-2222.2009.03364.x","type":"journal-article","created":{"date-parts":[[2009,11,13]],"date-time":"2009-11-13T07:58:38Z","timestamp":1258099118000},"page":"1875-1888","source":"Crossref","is-referenced-by-count":52,"title":["A multi\u2010centre study of candidate genes for wheeze and allergy: the International Study of Asthma and Allergies in Childhood Phase 2"],"prefix":"10.1111","volume":"39","author":[{"given":"J.","family":"Genuneit","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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