{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T14:33:13Z","timestamp":1784039593001,"version":"3.55.0"},"reference-count":56,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2009,12,15]],"date-time":"2009-12-15T00:00:00Z","timestamp":1260835200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2010,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background\n\t\t\t\t\t<\/jats:bold> Although hypersensitivity reactions following intake of alcoholic drinks are common in Caucasians, the underlying mechanisms and clinical significance are not known. In contrast, in Asians, alcohol\u2010induced asthma and flushing have been shown to be because of a single nucleotide polymorphism (SNP), the acetaldehyde dehydrogenase 2 (ALDH2) 487lys, causing decreased acetaldehyde (the metabolite of ethanol) metabolism and high levels of histamine. However, the ALDH2 487lys is absent in Caucasians.<\/jats:p><jats:p><jats:bold>Objectives\n\t\t\t\t\t<\/jats:bold> To investigate the genetic determinants of self\u2010reported alcohol\u2010induced hypersensitivity reactions in Caucasians.<\/jats:p><jats:p><jats:bold>Methods\n\t\t\t\t\t<\/jats:bold> The study included two population\u2010based studies of 1216 and 6784 adults living in Copenhagen. Assessment of alcohol consumption and hypersensitivity reactions (in a subgroup) was performed by a questionnaire and was related to common SNPs of genes encoding alcohol dehydrogenases (ADHs) and ALDHs.<\/jats:p><jats:p><jats:bold>Results\n\t\t\t\t\t<\/jats:bold> In both populations, alcohol drinkers with a genetically determined fast metabolism of ethanol (the A allele of the ADH1b rs1229984) had an increased risk of alcohol\u2010induced hypersensitivity reactions (odds ratio AA\/AG vs. GG in combined populations: 1.82, 95% CI 1.04\u20133.17). In both populations, a common SNP encoding ALDH1b1 (rs2228093) was found to be significantly associated with alcohol\u2010induced hypersensitivity (odds ratio TT vs. CC in combined populations: 2.53, 95% CI 1.31\u20134.90).<\/jats:p><jats:p><jats:bold>Conclusions\n\t\t\t\t\t<\/jats:bold> Our data support that alcohol sensitivity in Caucasians is genetically determined and suggest that a histamine\u2010releasing effect of acetaldehyde represents a plausible biological mechanism. Furthermore, we present the first report of a clinically significant SNP within the acetaldehyde\u2010metabolizing system in a Caucasian population.<\/jats:p><jats:p> <jats:italic>Cite this as:<\/jats:italic> A. Linneberg, A. Gonzalez\u2010Quintela, C. Vidal, T. J\u00f8rgensen, M. Fenger, T. Hansen, O. Pedersen and L. L. N. Husemoen, <jats:italic>Clinical &amp; Experimental Allergy<\/jats:italic>, 2010 (40) 123\u2013130.<\/jats:p>","DOI":"10.1111\/j.1365-2222.2009.03398.x","type":"journal-article","created":{"date-parts":[[2010,8,3]],"date-time":"2010-08-03T10:36:59Z","timestamp":1280831819000},"page":"123-130","source":"Crossref","is-referenced-by-count":70,"title":["Genetic determinants of both ethanol and acetaldehyde metabolism influence alcohol hypersensitivity and drinking behaviour among Scandinavians"],"prefix":"10.1111","volume":"40","author":[{"given":"A.","family":"Linneberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Gonzalez\u2010Quintela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Vidal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"J\u00f8rgensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Fenger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Hansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Pedersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. 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