{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T04:26:47Z","timestamp":1791001607245,"version":"4.1.0"},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2009,11,23]],"date-time":"2009-11-23T00:00:00Z","timestamp":1258934400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2010,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background\n\t\t\t\t\t<\/jats:bold> Allergic rhinitis (AR) is a relevant risk factor for the onset of asthma, and a close association exists between the nose and the bronchi. Recently, it has been evidenced that the duration of AR and mite allergy represent high risks for spirometric impairment in allergic adults.<\/jats:p><jats:p><jats:bold>Aim\n\t\t\t\t\t<\/jats:bold> To evaluate a group of AR children, without bronchial symptoms, to investigate spirometric impairments.<\/jats:p><jats:p><jats:bold>Methods\n\t\t\t\t\t<\/jats:bold> Two hundred children with moderate\u2010severe AR were consecutively evaluated. Clinical examination, skin prick test, and spirometry were performed in all children.<\/jats:p><jats:p><jats:bold>Results\n\t\t\t\t\t<\/jats:bold> Thirty\u2010one percent of the children had forced expiratory flow at 25% and 75% of the pulmonary volume (FEF<jats:sub>25\u201375%<\/jats:sub>)&lt;80% of the predicted values and 11% had both forced expiratory volume in 1\u2003s and FEF<jats:sub>25\u201375%<\/jats:sub>&lt;80% of the predicted values. Rhinitis duration and sensitization to house dust mites were significantly associated with impaired values of these spirometric parameters.<\/jats:p><jats:p><jats:bold>Conclusion\n\t\t\t\t\t<\/jats:bold> This study highlights the close link between the upper and the lower airways and the role of some risk factors, such as long duration and mite sensitization, as early prognostic markers of bronchial involvement in children with ARand perceiving nasal symptoms alone.<\/jats:p><jats:p> <jats:italic>Cite this as<\/jats:italic>: G. Ciprandi and M. Capasso, <jats:italic>Clinical &amp; Experimental Allergy<\/jats:italic>, 2010 (40) 398\u2013402.<\/jats:p>","DOI":"10.1111\/j.1365-2222.2009.03399.x","type":"journal-article","created":{"date-parts":[[2009,11,24]],"date-time":"2009-11-24T03:17:38Z","timestamp":1259032658000},"page":"398-402","source":"Crossref","is-referenced-by-count":13,"title":["Association of childhood perennial allergic rhinitis with subclinical airflow limitation"],"prefix":"10.1111","volume":"40","author":[{"given":"G.","family":"Ciprandi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Capasso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,2,8]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1983.tb00852.x"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2005.00659.x"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.20525"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1159\/000237378"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.162.3.9912030"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00035205"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00034805"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(97)70193-3"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1053\/rmed.2001.1148"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.52.12.1036"},{"key":"e_1_2_5_12_2","first-page":"882","article-title":"Seasonal and perennial allergic rhinitis","volume":"60","author":"Ciprandi G","year":"2005","journal-title":"is this classification adherent to real life? 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