{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T02:07:56Z","timestamp":1794017276304,"version":"4.8.0"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2009,12,16]],"date-time":"2009-12-16T00:00:00Z","timestamp":1260921600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2010,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background\n\t\t\t\t\t<\/jats:bold> Eosinophilic oesophagitis (EE) is a clinico\u2010pathologically defined oesophageal disorder that is characterized by eosinophil migration into oesophageal tissues. There is growing support for EE being an allergic disease and for a contribution of T\u2010helper type 2 (Th2)\u2010associated cytokines in disease pathogenesis. The respiratory system has been shown to be critical in driving the development of EE in animal models. However, the mechanisms underlying the recruitment of eosinophils into the oesophagus remain unclear.<\/jats:p><jats:p><jats:bold>Objective\n\t\t\t\t\t<\/jats:bold> We sought to investigate the influence of Th2\u2010associated cytokines on the production of eosinophil\u2010specific chemokines from the oesophagus directly.<\/jats:p><jats:p><jats:bold>Methods\n\t\t\t\t\t<\/jats:bold> In order to eliminate the potential involvement of the lung, we utilized isolated oesophageal rings. These were treated <jats:italic>in vitro<\/jats:italic> with IL\u20104 or IL\u201013 and the expression and production of CCL11 and CCL24 were determined.<\/jats:p><jats:p><jats:bold>Results\n\t\t\t\t\t<\/jats:bold> Our data demonstrate that IL\u201013 is a potent and direct inducer of both CCL11 and CCL24 production from the oesophagus, as is IL\u20104 also. The expression of CCL11 precedes CCL24 by several hours but then diminishes over time, as well as at high concentrations of IL\u201013. We demonstrate that there is an up\u2010regulation of the inhibitory IL\u201013 receptor, IL\u201013R\u03b12 but that IL\u201013R\u03b11 remains unaltered. Oesophagus rings isolated from STAT6<jats:sup>\u2212\/\u2212<\/jats:sup> mice were unable to produce CCL11 or CCL24 upon IL\u201013 treatment. Lastly, we demonstrate that oesophageal production of CCL11 and CCL24 upon IL\u201013 stimulation is sufficient to promote eosinophil migration.<\/jats:p><jats:p><jats:bold>Conclusions\n\t\t\t\t\t<\/jats:bold> IL\u201013 is capable of directly stimulating oesophageal tissue to produce eosinophil\u2010attracting chemokines and drive eosinophil migration.<\/jats:p><jats:p> <jats:italic>Cite this as<\/jats:italic>: C. V. Neilsen and P. J. Bryce, <jats:italic>Clinical &amp; Experimental Allergy<\/jats:italic>, 2010 (40) 427\u2013434.<\/jats:p>","DOI":"10.1111\/j.1365-2222.2009.03419.x","type":"journal-article","created":{"date-parts":[[2010,2,8]],"date-time":"2010-02-08T07:47:42Z","timestamp":1265615262000},"page":"427-434","source":"Crossref","is-referenced-by-count":50,"title":["Interleukin\u201013 directly promotes oesophagus production of CCL11 and CCL24 and the migration of eosinophils"],"prefix":"10.1111","volume":"40","author":[{"given":"C. V.","family":"Neilsen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. J.","family":"Bryce","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,2,8]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"1342","article-title":"Eosinophilic esophagitis in children and adults","volume":"133","author":"Furuta GT","year":"2007","journal-title":"a systematic review and consensus recommendations for diagnosis and treatment"},{"key":"e_1_2_6_3_2","first-page":"119","article-title":"Eosinophilic esophagitis","volume":"18","author":"Assa'ad A.","year":"2008","journal-title":"association with allergic disorders"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2007.12.045"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0546(07)70227-6"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2007.01454.x"},{"key":"e_1_2_6_7_2","first-page":"22","article-title":"Cytokine expression in normal and inflamed esophageal mucosa","volume":"42","author":"Gupta SK","year":"2006","journal-title":"a study into the pathogenesis of allergic eosinophilic esophagitis"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI26679"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2001.119917"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.169.2.1021"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI10224"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gastro.2003.07.007"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2005.02299.x"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.176.12.7495"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0700185104"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.168.5.2464"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm734"},{"key":"e_1_2_6_18_2","first-page":"1292","article-title":"IL\u201013 involvement in eosinophilic esophagitis","volume":"120","author":"Blanchard C","year":"2007","journal-title":"transcriptome analysis and reversibility with glucocorticoids"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.1.51.pe55"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M506770200"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI25711"},{"key":"e_1_2_6_22_2","first-page":"147","article-title":"Role of STAT6 and SMAD2 in a model of chronic allergen exposure","volume":"39","author":"Hirota JA","year":"2009","journal-title":"a mouse strain comparison study"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/s100249900084"},{"key":"e_1_2_6_24_2","first-page":"1946","article-title":"Eotaxin protein and gene expression in guinea\u2010pig lungs","volume":"10","author":"Li D","year":"1997","journal-title":"constitutive expression and upregulation after allergen challenge"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.7861\/clinmedicine.1-3-214"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80439-2"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2007.02871.x"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.1106653"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2005.01.017"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2003.01827.x"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.155.6.3234"}],"container-title":["Clinical &amp; Experimental Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2222.2009.03419.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2222.2009.03419.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T20:34:45Z","timestamp":1698784485000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2222.2009.03419.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,2,8]]},"references-count":30,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2010,3]]}},"alternative-id":["10.1111\/j.1365-2222.2009.03419.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2222.2009.03419.x","archive":["Portico"],"relation":{},"ISSN":["0954-7894","1365-2222"],"issn-type":[{"value":"0954-7894","type":"print"},{"value":"1365-2222","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,2,8]]}}}