{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T17:26:11Z","timestamp":1793294771882,"version":"4.5.0"},"reference-count":37,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2010,1,11]],"date-time":"2010-01-11T00:00:00Z","timestamp":1263168000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2010,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background\n\t\t\t\t\t<\/jats:bold> The incidence of atopic disease has increased dramatically during recent decades and the potential immunoregulatory influence of the microbiota in these individuals is under investigation.<\/jats:p><jats:p><jats:bold>Objective\n\t\t\t\t\t<\/jats:bold> The aim of our study was to identify a bacterial strain that is protective in murine allergy models and to determine if microbial induction of T regulatory cells was associated with protection from allergic inflammation.<\/jats:p><jats:p><jats:bold>Methods\n\t\t\t\t\t<\/jats:bold> Three microbes (<jats:italic>Bifidobacterium breve<\/jats:italic> AH1205, <jats:italic>B. longum<\/jats:italic> AH1206 and <jats:italic>Lactobacillus salivarius<\/jats:italic> AH102) of human origin were fed to newborn, adult and germ\u2010free animals. Induction of Foxp3<jats:sup>+<\/jats:sup> T regulatory cells was assessed by flow cytometry. Gene array analysis was performed on Peyer's patches. Strains were also examined for their protective effects in the ovalbumin (OVA) respiratory allergy model and the OVA\u2010cholera toxin dietary allergy model.<\/jats:p><jats:p><jats:bold>Results\n\t\t\t\t\t<\/jats:bold>  <jats:italic>Bifidobacterium longum<\/jats:italic> AH1206 consumption resulted in increased numbers of Foxp3<jats:sup>+<\/jats:sup> T regulatory cells in infant, adult and germ\u2010free animals. <jats:italic>B. breve<\/jats:italic> AH1205 induced Foxp3<jats:sup>+<\/jats:sup> T regulatory cell expansion only in infant mice while <jats:italic>L. salivarius<\/jats:italic> AH102 did not alter T regulatory cell numbers in any animal model tested. <jats:italic>B. longum<\/jats:italic> AH1206 reduced the Peyer's patch gene expression associated with antigen presentation, TLR signalling and cytokine production while increasing the expression of genes associated with retinoic acid metabolism. <jats:italic>B. longum<\/jats:italic> AH1206 protected against airway inflammation in OVA\u2010sensitized animals and <jats:italic>B. longum<\/jats:italic> AH1206 blocked the induction of IgE to orally administered OVA. Neither <jats:italic>B. breve<\/jats:italic> AH1205 nor <jats:italic>L. salivarius<\/jats:italic> AH102 had a protective effect in either model.<\/jats:p><jats:p><jats:bold>Conclusion\n\t\t\t\t\t<\/jats:bold> Bacterial strain\u2010specific induction of Foxp3<jats:sup>+<\/jats:sup> T regulatory cells <jats:italic>in vivo<\/jats:italic> is associated with protection from respiratory and oral allergy.<\/jats:p><jats:p> <jats:italic>Cite this as:<\/jats:italic> A. Lyons, D. O'Mahony, F. O'Brien, J. MacSharry, B. Sheil, M. Ceddia, W. M.Russell, P. ForsytheJ. Bienenstock, B. Kiely, F. Shanahan and L. O'Mahony, <jats:italic>Clinical &amp; Experimental Allergy<\/jats:italic>, 2010 (40) 811\u2013819.<\/jats:p>","DOI":"10.1111\/j.1365-2222.2009.03437.x","type":"journal-article","created":{"date-parts":[[2010,1,11]],"date-time":"2010-01-11T16:03:59Z","timestamp":1263225839000},"page":"811-819","source":"Crossref","is-referenced-by-count":205,"title":["Bacterial strain\u2010specific induction of Foxp3<sup>+<\/sup> T regulatory cells is protective in murine allergy models"],"prefix":"10.1111","volume":"40","author":[{"given":"A.","family":"Lyons","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"O'Mahony","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"O'Brien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"MacSharry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Sheil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Ceddia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. 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