{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T20:14:23Z","timestamp":1792700063718,"version":"4.5.0"},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2010,2,8]],"date-time":"2010-02-08T00:00:00Z","timestamp":1265587200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2010,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background\n\t\t\t\t\t<\/jats:bold> Rhinitis is characterized by inflammation of the mucous membranes lining the nose and can be divided into two categories, allergic and non\u2010allergic. Drug\u2010induced is a type of non\u2010allergic rhinitis.<\/jats:p><jats:p><jats:bold>Objective\n\t\t\t\t\t<\/jats:bold> A review of the literature was conducted. Very little is known about this topic and there are no publications to date solely devoted to drug\u2010induced rhinitis.<\/jats:p><jats:p><jats:bold>Methods\n\t\t\t\t\t<\/jats:bold> A PubMed and Medline search was conducted using a combination of the keywords; drug, medication, rhinitis, congestion, rhinorrhea, sneezing, pruritus, vasomotor, reflex, neurogenic, allergic and non\u2010allergic. Medications that were found in the search were then cross\u2010referenced with the physicians desk reference and Epocrates. The final literature search was conducted in August 2009.<\/jats:p><jats:p><jats:bold>Results\n\t\t\t\t\t<\/jats:bold> Three categories of drug\u2010induced rhinitis exist based on the mechanism of action. These include local inflammatory, neurogenic and idiopathic types. Rhinitis medicamentosa, a form of drug\u2010induced rhinitis, has unique characteristics.<\/jats:p><jats:p><jats:bold>Conclusion\n\t\t\t\t\t<\/jats:bold> When possible, the offending medication should be discontinued or substituted. Although there are no established treatment recommendations for drug\u2010induced rhinitis other than avoidance, clinical experience suggests that it would be reasonable to initiate use of an intranasal corticosteroid spray to treat symptomatically. The addition of an intranasal antihistamine in combination with use of an intranasal corticosteroid may be considered as step\u2010up therapy if the intranasal corticosteroid alone is not effective.<\/jats:p><jats:p> <jats:italic>Cite this as<\/jats:italic>: M. Varghese, M. C. Glaum and R. F. Lockey, <jats:italic>Clinical &amp; Experimental Allergy<\/jats:italic>, 2010 (40) 381\u2013384.<\/jats:p>","DOI":"10.1111\/j.1365-2222.2009.03450.x","type":"journal-article","created":{"date-parts":[[2010,2,8]],"date-time":"2010-02-08T07:47:42Z","timestamp":1265615262000},"page":"381-384","source":"Crossref","is-referenced-by-count":84,"title":["Drug\u2010induced rhinitis"],"prefix":"10.1111","volume":"40","author":[{"given":"M.","family":"Varghese","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. C.","family":"Glaum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. 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