{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T22:38:32Z","timestamp":1770503912986,"version":"3.49.0"},"reference-count":45,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2010,3,12]],"date-time":"2010-03-12T00:00:00Z","timestamp":1268352000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2010,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background\n\t\t\t\t\t<\/jats:bold> Tamoxifen (TX) represents the prototype selective oestrogen receptor modulator. In addition to its use in breast cancer, TX possesses immunomodulatory functions and displays beneficial effects in models of systemic lupus erythematosus. We hypothesized that TX might inhibit type I allergic reactions, which are also characterized by deviations in humoral immunity.<\/jats:p><jats:p><jats:bold>Objective\n\t\t\t\t\t<\/jats:bold> To evaluate the effects of TX on the allergic immune response in appropriate mouse models.<\/jats:p><jats:p><jats:bold>Methods\n\t\t\t\t\t<\/jats:bold> Balb\/c mice were sensitized with ovalbumin (OVA)\u2010alum by the intraperitoneal route, and humoral parameters, T cell cytokine patterns and OVA\u2010induced ear swelling responses were determined in a preventive (start of TX treatment before sensitization) and a therapeutic setting (start after sensitization), respectively. In addition, the impact of TX on clinical signs, epidermal thickness and leucocyte infiltration of the skin was investigated in a model of allergen\u2010induced dermatitis.<\/jats:p><jats:p><jats:bold>Results\n\t\t\t\t\t<\/jats:bold> Preventive TX treatment interfered with all aspects of the allergic immune response, leading to a reduction of allergen\u2010specific Ig levels (IgE, IgG1 and IgG2a), a skewing effect in the T cell compartment with the inhibition of IL\u20104 and an abrogation of ear swelling responses. Interestingly, a therapeutic TX administration was also effective in reducing Ig levels and ear swelling responses. The vigorous systemic effects were additionally mirrored by local changes in allergen\u2010dependent dermatitis with reduced clinical symptoms, diminished epidermal thickness and decreased CD4<jats:sup>+<\/jats:sup> and CD8<jats:sup>+<\/jats:sup> cell infiltrates.<\/jats:p><jats:p><jats:bold>Conclusion\n\t\t\t\t\t<\/jats:bold> TX inhibits allergic responses when given preventively and also therapeutically, and improves allergen\u2010induced dermatitis. Because of its effectiveness, TX could bear significant therapeutic potential for the treatment of allergies.<\/jats:p><jats:p> <jats:italic>Cite this as<\/jats:italic>: M. Babina, F. Kirn, D. Hoser, D. Ernst, W. Rohde, T. Zuberbier and M. Worm, <jats:italic>Clinical &amp; Experimental Allergy<\/jats:italic>, 2010 (40) 1256\u20131265.<\/jats:p>","DOI":"10.1111\/j.1365-2222.2010.03472.x","type":"journal-article","created":{"date-parts":[[2010,7,7]],"date-time":"2010-07-07T15:55:57Z","timestamp":1278518157000},"page":"1256-1265","source":"Crossref","is-referenced-by-count":27,"title":["Tamoxifen counteracts the allergic immune response and improves allergen\u2010induced dermatitis in 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