{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T20:03:19Z","timestamp":1774123399254,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2010,3,11]],"date-time":"2010-03-11T00:00:00Z","timestamp":1268265600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2010,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background\n\t\t\t\t\t<\/jats:bold> The rising global prevalence of asthma and other allergic conditions has been linked to potential aetiological factors influencing the developing immune system.<\/jats:p><jats:p><jats:bold>Objective\n\t\t\t\t\t<\/jats:bold> To investigate the prevalence and associated risk factors for wheeze and eczema in 1\u2010year\u2010old children in a birth cohort from Butajira, Ethiopia.<\/jats:p><jats:p><jats:bold>Methods\n\t\t\t\t\t<\/jats:bold> In 2005\/6, a population\u2010based cohort of 1065 pregnant women was established. At 1 year of age, data on wheeze and eczema in the children were collected from the mother via an interview\u2010administered questionnaire, along with numerous demographic and lifestyle factors. A stool sample was also obtained from the child for geohelminth analysis.<\/jats:p><jats:p><jats:bold>Results\n\t\t\t\t\t<\/jats:bold> The prevalence of wheeze was 11.5% (103\/899) and eczema 8.6% (77\/899). Independent predictors of wheeze were maternal allergic history [adjusted OR (AOR)=3.00, 95% CI 1.23\u20137.36], paternal allergic history (AOR=2.59, 95% CI 1.08\u20136.25), increasing household size (<jats:italic>P<\/jats:italic> for trend=0.023; AOR=3.54, 95% CI 1.31\u20139.56 for 7+ vs. 1\u20133 individuals) and paracetamol use by the child (overall <jats:italic>P<\/jats:italic>&lt;0.001; AOR 11.04, 95% CI 4.30\u201328.31 for 4+ tablets in past month vs. never). Factors independently associated with eczema were maternal allergic history (AOR=3.68, 95% CI 1.54\u20138.77), household size (overall <jats:italic>P<\/jats:italic>=0.035; AOR=0.45, 95% CI 0.23\u20130.87 for 4\u20136 individuals relative to 1\u20133) and place of sleeping (overall <jats:italic>P<\/jats:italic>&lt;0.001; AOR=0.29, 95% CI 0.10\u20130.82 for floor vs. bed\/platform).<\/jats:p><jats:p><jats:bold>Conclusion\n\t\t\t\t\t<\/jats:bold> These findings support the hypothesis that eczema in early life in these children is a manifestation of allergy, while wheezing is probably due to infection as well as allergy.<\/jats:p><jats:p> <jats:italic>Cite this as<\/jats:italic>: Y. Belyhun, A. Amberbir, G. Medhin, B. Erko, C. Hanlon, A. Venn, J. Britton and G. Davey, <jats:italic>Clinical &amp; Experimental Allergy<\/jats:italic>, 2010 (40) 619\u2013626.<\/jats:p>","DOI":"10.1111\/j.1365-2222.2010.03479.x","type":"journal-article","created":{"date-parts":[[2010,8,3]],"date-time":"2010-08-03T00:31:56Z","timestamp":1280795516000},"page":"619-626","source":"Crossref","is-referenced-by-count":22,"title":["Prevalence and risk factors of wheeze and eczema in 1\u2010year\u2010old children: the Butajira birth cohort, Ethiopia"],"prefix":"10.1111","volume":"40","author":[{"given":"Y.","family":"Belyhun","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Amberbir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Medhin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Erko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Hanlon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Venn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Britton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Davey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,3,11]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/jech.56.3.209"},{"key":"e_1_2_6_3_2","first-page":"74","article-title":"Immune 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