{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T02:58:56Z","timestamp":1792119536141,"version":"4.4.0"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2010,3,11]],"date-time":"2010-03-11T00:00:00Z","timestamp":1268265600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2010,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background\n\t\t\t\t\t<\/jats:bold> Allergy to fig fruit (<jats:italic>Ficus carica<\/jats:italic>) has been described in patients allergic to <jats:italic>Ficus benjamina<\/jats:italic> or rubber latex but may occur also in pollen\u2010allergic patients.<\/jats:p><jats:p><jats:bold>Objective\n\t\t\t\t\t<\/jats:bold> To study the potential cross\u2010reactivity between fig and taxonomically related fruits with the major birch pollen allergen Bet v 1.<\/jats:p><jats:p><jats:bold>Methods\n\t\t\t\t\t<\/jats:bold> One hundred and eighty\u2010eight patients with or without birch pollen allergy were prick\u2010to\u2010prick tested with fig (<jats:italic>F. carica<\/jats:italic>), mulberry (<jats:italic>Morus alba<\/jats:italic>), jackfruit (<jats:italic>Artocarpus heterophyllus<\/jats:italic>; all family Moraceae) and other pollen\u2010associated foods. Moraceae fruit extracts were separated by SDS\u2010PAGE and tested with patient sera and polyclonal antisera against Mal d 1. Western blot inhibition was performed with Moraceae fruit extracts, birch pollen and recombinant Bet v 1. Putative Bet v 1 homologs in Moraceae fruits were analysed by liquid chromatography\u2010ion trap mass spectrometry.<\/jats:p><jats:p><jats:bold>Results\n\t\t\t\t\t<\/jats:bold> Among 85 patients with isolated birch pollen allergy, 78% had a positive skin test to fresh fig, 10% to dried fig, 91% to mulberry, 91% to jackfruit, 77% to Rosaceae fruits and 83% to hazelnut. Sixty\u2010six per cent of birch pollen\u2010allergic patients positive for fig, reported symptoms after consumption of fresh figs, whereas dried figs were mostly well tolerated. In 60 patients with isolated <jats:italic>Ficus benjamina<\/jats:italic> sensitization, the reactivity rates to the same foods were 83\u201040\u20100\u20100\u20100\u20100%. None of 32 mugwort pollen\u2010allergic patients reacted to Moraceae fruits. Rabbit anti\u2010Mal d 1 and patient sera reacted to a 17\u2003kDa band in all Moraceae extracts. IgE binding to these proteins was completely inhibited by birch pollen and rBet v 1. Mass spectrometry identified several peptides from the 17\u2003kDa fig, mulberry and jackfruit allergen with respectively 60%, 56% and 76% homology to Bet v 1.<\/jats:p><jats:p><jats:bold>Conclusion\n\t\t\t\t\t<\/jats:bold> Fig and other Moraceae fruits contain allergens homologous to Bet v 1 and represent clinically relevant birch pollen\u2010associated foods.<\/jats:p><jats:p> <jats:italic>Cite this as<\/jats:italic>: W. Hemmer, M. Focke, G. Marzban, I. Swoboda, R. Jarisch and M. Laimer, <jats:italic>Clinical &amp; Experimental Allergy<\/jats:italic>, 2010 (40) 679\u2013687.<\/jats:p>","DOI":"10.1111\/j.1365-2222.2010.03486.x","type":"journal-article","created":{"date-parts":[[2010,8,3]],"date-time":"2010-08-03T10:27:15Z","timestamp":1280831235000},"page":"679-687","source":"Crossref","is-referenced-by-count":31,"title":["Identification of Bet v 1\u2010related allergens in fig and other Moraceae fruits"],"prefix":"10.1111","volume":"40","author":[{"given":"W.","family":"Hemmer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Focke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Marzban","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Swoboda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Jarisch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Laimer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,3,11]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1995.tb01188.x"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.2003.01704.x"},{"key":"e_1_2_6_4_2","first-page":"1251","article-title":"Sensitization to Ficus benjamina","volume":"34","author":"Hemmer W","year":"2004","journal-title":"relationship to natural rubber latex allergy and identification of foods implicated in the ficus-fruit syndrome"},{"key":"e_1_2_6_5_2","first-page":"309","article-title":"Latex allergy","volume":"73","author":"Blanco C","year":"1994","journal-title":"clinical features and cross-reactivity with fruits"},{"key":"e_1_2_6_6_2","first-page":"404","article-title":"\u201cLatex\u2010fruit syndrome\u201d","volume":"52","author":"Brehler R","year":"1997","journal-title":"frequency of cross-reacting IgE antibodies"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1998.tb04092.x"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1159\/000053641"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1159\/000070929"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)61520-7"},{"key":"e_1_2_6_11_2","first-page":"1187","article-title":"Allergy to jackfruit","volume":"59","author":"Bolhaar ST","year":"2004","journal-title":"a novel example of Bet v 1-related food allergy"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.plantsci.2005.03.027"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/elps.1150070108"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3040.2004.01216.x"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2007.07.024"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1982.tb02323.x"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1323-8930.2003.00303.x"},{"key":"e_1_2_6_18_2","first-page":"135","article-title":"Nahrungsmittelallergien \u2013 oropharyngeale Reaktionen","volume":"139","author":"Kremser M.","year":"1989","journal-title":"Wien Med Wschr"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1997.tb01023.x"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1586\/14789450.5.1.61"},{"key":"e_1_2_6_21_2","first-page":"182","article-title":"Urticaria and rhinitis to shrubs of Ficus benjamina and breadfruit in a banana\u2010allergic road worker","volume":"125","author":"De Greef JM","year":"2001","journal-title":"evidence for cross-sensitization between Moraceae, banana and latex"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.1996.tb00557.x"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.2000.00751.x"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2003.10.059"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1159\/000102615"},{"key":"e_1_2_6_26_2","first-page":"102","article-title":"A case of allergy to globe artichoke and other clinical cases of rare food allergy","volume":"10","author":"Romano C","year":"2000","journal-title":"J Investig Allergol Clin Immunol"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1995.tb00855.x"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0546(04)79244-7"}],"container-title":["Clinical &amp; 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