{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T11:04:16Z","timestamp":1790939056747,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2010,6,28]],"date-time":"2010-06-28T00:00:00Z","timestamp":1277683200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2010,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background\n\t\t\t\t\t<\/jats:bold> Probiotics are perceived to exert beneficial effects in the prevention and treatment of allergic diseases.<\/jats:p><jats:p><jats:bold>Objective\n\t\t\t\t\t<\/jats:bold> There are conflicting data from studies as to an impact on allergic sensitization and asthma.<\/jats:p><jats:p><jats:bold>Methods\n\t\t\t\t\t<\/jats:bold> Our prospective double\u2010blind study randomly assigned 131 children (6\u201324 months old) with at least two wheezing episodes and a first\u2010degree family history of atopic disease to 6 months of <jats:italic>Lactobacillus rhamnosus<\/jats:italic> (<jats:italic>LGG<\/jats:italic>, 10<jats:sup>10<\/jats:sup> colony forming units) or placebo. Atopic dermatitis and asthma\u2010related events (e.g. need of inhalation, symptom\u2010free days) were documented throughout the intervention and 6\u2010month follow\u2010up. We determined IgE, a representative panel of specific IgE, eosinophils, eosinophilic cationic protein, and TGF\u2010\u03b2 before, at the end of intervention, and after 6 months of follow\u2010up.<\/jats:p><jats:p><jats:bold>Results\n\t\t\t\t\t<\/jats:bold> There were no significant differences as to atopic dermatitis or asthma\u2010related events. In a subgroup with antecedent allergic sensitizations, asthmatic complaints were even slightly worse. We found fewer sensitizations towards aeroallergens after 6 months of <jats:italic>LGG<\/jats:italic> (<jats:italic>P<\/jats:italic>=0.027) and after 6 months of follow\u2010up (<jats:italic>P<\/jats:italic>=0.03). Supplementation was well\u2010tolerated and no severe adverse events occurred.<\/jats:p><jats:p><jats:bold>Conclusions\n\t\t\t\t\t<\/jats:bold> In young children with recurrent wheeze and an atopic family history, oral <jats:italic>LGG<\/jats:italic> had no clinical effect on atopic dermatitis or asthma\u2010related events, and only mild effects on allergic sensitization. This effect persisted 6 months after the cessation of the supplementation.<\/jats:p><jats:p> <jats:italic>Cite this as<\/jats:italic>: M. A. Rose, F. Stieglitz, A. K\u00f6ksal, R. Schubert, J. Schulze and S. Zielen, <jats:italic>Clinical &amp; Experimental Allergy<\/jats:italic>, 2010 (40) 1398\u20131405.<\/jats:p>","DOI":"10.1111\/j.1365-2222.2010.03560.x","type":"journal-article","created":{"date-parts":[[2010,6,29]],"date-time":"2010-06-29T02:43:49Z","timestamp":1277779429000},"page":"1398-1405","source":"Crossref","is-referenced-by-count":100,"title":["Efficacy of probiotic <i>Lactobacillus GG<\/i> on allergic sensitization and asthma in infants at risk"],"prefix":"10.1111","volume":"40","author":[{"given":"M. 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