{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T22:30:17Z","timestamp":1767911417608,"version":"3.49.0"},"reference-count":41,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2011,3,24]],"date-time":"2011-03-24T00:00:00Z","timestamp":1300924800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2011,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background\n\t\t\t\t\t<\/jats:bold> Orally administered milk fat enriched in conjugated linoleic acid (CLA) and <jats:italic>trans<\/jats:italic>\u2010vaccenic acid (VA) (\u2018enriched milk fat\u2019), produced by supplementing the diet of pasture\u2010fed cows with fish and sunflower oil, has been shown previously to suppress the development of allergic airway disease in mice.<\/jats:p><jats:p><jats:bold>Objective\n\t\t\t\t\t<\/jats:bold> To investigate whether topical or oral application of enriched milk fat and its two major fatty acids <jats:italic>cis<\/jats:italic>\u20109, <jats:italic>trans<\/jats:italic>\u201011 CLA (c9,t11\u2010CLA) and VA inhibit allergic dermatitis in mice.<\/jats:p><jats:p><jats:bold>Methods\n\t\t\t\t\t<\/jats:bold> Allergic dermatitis was induced in C57BL\/6 mice by epicutaneous sensitization of tape\u2010stripped skin with ovalbumin (OVA). Enriched milk fat and its two major fatty acids were either topically applied to the OVA\u2010sensitized skin, or orally fed to mice by supplementation of the diet. Blood and skin tissues were collected for analysis after the third skin sensitization.<\/jats:p><jats:p><jats:bold>Results\n\t\t\t\t\t<\/jats:bold> Both topical and oral administration of enriched milk fat and its two major fatty acids led to significant suppression of allergic dermatitis as evidenced by reduced clinical and histological scores of affected skins, infiltration of inflammatory cells, and circulating allergen\u2010specific IgE levels, compared with treatment with normal milk fat or the base control diet. C9,t11\u2010CLA and VA individually inhibited multiple facets of allergic dermatitis when topically applied, and their combination produced a strong additive effect.<\/jats:p><jats:p><jats:bold>Conclusion and Clinical Relevance\n\t\t\t\t\t<\/jats:bold> Enriched milk fat, and its two major fatty acids c9,t11\u2010CLA and vaccenic acid attenuate allergic dermatitis in mice.<\/jats:p><jats:p> <jats:italic>Cite this as<\/jats:italic>: X. Sun, J. Zhang, A. K. H. MacGibbon, P. Black and G. W. Krissansen, Clinical &amp; Experimental Allergy, 2011 (41) 729\u2013738.<\/jats:p>","DOI":"10.1111\/j.1365-2222.2011.03723.x","type":"journal-article","created":{"date-parts":[[2011,3,24]],"date-time":"2011-03-24T06:41:11Z","timestamp":1300948871000},"page":"729-738","source":"Crossref","is-referenced-by-count":24,"title":["Bovine milk fat enriched in conjugated linoleic and vaccenic acids attenuates allergic dermatitis in mice"],"prefix":"10.1111","volume":"41","author":[{"given":"X.","family":"Sun","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. K. H.","family":"MacGibbon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Black","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. 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