{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T10:25:26Z","timestamp":1776335126216,"version":"3.51.2"},"reference-count":24,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":1608,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,7]]},"DOI":"10.1111\/j.1365-2222.2011.03728.x","type":"journal-article","created":{"date-parts":[[2011,4,7]],"date-time":"2011-04-07T11:00:05Z","timestamp":1302174005000},"page":"1012-1021","source":"Crossref","is-referenced-by-count":16,"title":["Tim1 and Tim3 are not essential for experimental allergic asthma"],"prefix":"10.1111","volume":"41","author":[{"given":"J. L.","family":"Barlow","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. H.","family":"Wong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. J.","family":"Ballantyne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. E.","family":"Jolin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. N. J.","family":"McKenzie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,4,7]]},"reference":[{"key":"10.1111\/j.1365-2222.2011.03728.x-BIB1|cit1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S1074-7613(02)00332-1","article-title":"IL-4 induces characteristic Th2 responses even in the combined absence of IL-5, IL-9, and IL-13","volume":"17","author":"Fallon","year":"2002","journal-title":"Immunity"},{"key":"10.1111\/j.1365-2222.2011.03728.x-BIB2|cit2","doi-asserted-by":"crossref","first-page":"S477","DOI":"10.1016\/S0091-6749(00)90046-0","article-title":"Mapping susceptibility genes for asthma and allergy","volume":"105","author":"Howard","year":"2000","journal-title":"J Allergy Clin Immunol"},{"key":"10.1111\/j.1365-2222.2011.03728.x-BIB3|cit3","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1084\/jem.189.10.1565","article-title":"Simultaneous disruption of interleukin (IL)-4 and IL-13 defines individual roles in T helper cell type 2-mediated responses","volume":"189","author":"McKenzie","year":"1999","journal-title":"J Exp Med"},{"key":"10.1111\/j.1365-2222.2011.03728.x-BIB4|cit4","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1084\/jem.20011732","article-title":"The absence of interleukin 9 does not affect the development of allergen-induced pulmonary inflammation nor airway hyperreactivity","volume":"195","author":"McMillan","year":"2002","journal-title":"J Exp Med"},{"key":"10.1111\/j.1365-2222.2011.03728.x-BIB5|cit5","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/S1074-7613(00)00056-X","article-title":"IL-9-deficient mice establish fundamental roles for IL-9 in pulmonary mastocytosis and goblet cell hyperplasia but not T cell development","volume":"13","author":"Townsend","year":"2000","journal-title":"Immunity"},{"key":"10.1111\/j.1365-2222.2011.03728.x-BIB6|cit6","first-page":"2258","article-title":"Interleukin-13","volume":"282","author":"Wills-Karp","year":"1998","journal-title":"central mediator of allergic asthma"},{"key":"10.1111\/j.1365-2222.2011.03728.x-BIB7|cit7","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1038\/ni739","article-title":"Identification of Tapr (an airway hyperreactivity regulatory locus) and the linked Tim gene family","volume":"2","author":"McIntire","year":"2001","journal-title":"Nat Immunol"},{"key":"10.1111\/j.1365-2222.2011.03728.x-BIB8|cit8","first-page":"576","article-title":"Immunology","volume":"425","author":"McIntire","year":"2003","journal-title":"hepatitis A virus link to atopic disease"},{"key":"10.1111\/j.1365-2222.2011.03728.x-BIB9|cit9","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1159\/000103992","article-title":"A functional polymorphism in the TIM-1 gene is associated with asthma in a Chinese Han population","volume":"144","author":"Liu","year":"2007","journal-title":"Int ArchAllergy Immunol"},{"key":"10.1111\/j.1365-2222.2011.03728.x-BIB10|cit10","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/j.jaci.2005.05.004","article-title":"Association of atopy and eczema with polymorphisms in T-cell immunoglobulin domain and mucin domain-IL-2-inducible T-cell kinase gene cluster in chromosome 5 q 33","volume":"116","author":"Graves","year":"2005","journal-title":"J Allergy Clin Immunol"},{"key":"10.1111\/j.1365-2222.2011.03728.x-BIB11|cit11","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1038\/ni1185","article-title":"TIM-4 is the ligand for TIM-1, and the TIM-1-TIM-4 interaction regulates T cell proliferation","volume":"6","author":"Meyers","year":"2005","journal-title":"Nat Immunol"},{"key":"10.1111\/j.1365-2222.2011.03728.x-BIB12|cit12","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1038\/ni1186","article-title":"TIM-1 induces T cell activation and inhibits the development of peripheral tolerance","volume":"6","author":"Umetsu","year":"2005","journal-title":"Nat Immunol"},{"key":"10.1111\/j.1365-2222.2011.03728.x-BIB13|cit13","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1016\/j.jaci.2005.08.031","article-title":"Anti-T-cell Ig and mucin domain-containing protein 1 antibody decreases TH2 airway inflammation in a mouse model of asthma","volume":"116","author":"Encinas","year":"2005","journal-title":"J Allergy Clin Immunol"},{"key":"10.1111\/j.1365-2222.2011.03728.x-BIB14|cit14","doi-asserted-by":"crossref","first-page":"2249","DOI":"10.4049\/jimmunol.178.4.2249","article-title":"Epitope-dependent effect of anti-murine TIM-1 monoclonal antibodies on T cell activity and lung immune responses","volume":"178","author":"Sizing","year":"2007","journal-title":"J Immunol"},{"key":"10.1111\/j.1365-2222.2011.03728.x-BIB15|cit15","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1084\/jem.20062498","article-title":"Differential engagement of Tim-1 during activation can positively or negatively costimulate T cell expansion and effector function","volume":"204","author":"Xiao","year":"2007","journal-title":"J Exp Med"},{"key":"10.1111\/j.1365-2222.2011.03728.x-BIB16|cit16","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1084\/jem.20062093","article-title":"Th2-driven, allergen-induced airway inflammation is reduced after treatment with anti-Tim-3 antibody in vivo","volume":"204","author":"Kearley","year":"2007","journal-title":"J Exp Med"},{"key":"10.1111\/j.1365-2222.2011.03728.x-BIB17|cit17","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1111\/j.1365-2567.2010.03276.x","article-title":"Tim-1 is induced on germinal centre B cells through B-cell receptor signalling but is not essential for the germinal centre response","volume":"131","author":"Wong","year":"2010","journal-title":"Immunology"},{"key":"10.1111\/j.1365-2222.2011.03728.x-BIB18|cit18","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/0022-1759(93)90386-L","article-title":"Detection of in vivo expression of interleukin-10 using a semi-quantitative polymerase chain reaction method in Schistosoma mansoni infected mice","volume":"162","author":"Murphy","year":"1993","journal-title":"J Immunol Methods"},{"key":"10.1111\/j.1365-2222.2011.03728.x-BIB19|cit19","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1016\/j.jaci.2007.07.051","article-title":"Blocking IL-25 prevents airway hyperresponsiveness in allergic asthma","volume":"120","author":"Ballantyne","year":"2007","journal-title":"J Allergy Clin Immunol"},{"key":"10.1111\/j.1365-2222.2011.03728.x-BIB20|cit20","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1038\/ni987","article-title":"Tim-3 inhibits T helper type 1-mediated auto- and alloimmune responses and promotes immunological tolerance","volume":"4","author":"Sanchez-Fueyo","year":"2003","journal-title":"Nat Immunol"},{"key":"10.1111\/j.1365-2222.2011.03728.x-BIB21|cit21","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1126\/science.1148536","article-title":"Promotion of tissue inflammation by the immune receptor Tim-3 expressed on innate immune cells","volume":"318","author":"Anderson","year":"2007","journal-title":"Science"},{"key":"10.1111\/j.1365-2222.2011.03728.x-BIB22|cit22","doi-asserted-by":"crossref","first-page":"4311","DOI":"10.4049\/jimmunol.177.7.4311","article-title":"T cell, Ig domain, mucin domain-2 gene-deficient mice reveal a novel mechanism for the regulation of Th2 immune responses and airway inflammation","volume":"177","author":"Rennert","year":"2006","journal-title":"J Immunol"},{"key":"10.1111\/j.1365-2222.2011.03728.x-BIB23|cit23","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1016\/j.jaci.2005.01.035","article-title":"Genetic variants of the T-cell immunoglobulin mucin 1 but not the T-cell immunoglobulin mucin 3 gene are associated with asthma in an African American population","volume":"115","author":"Gao","year":"2005","journal-title":"J Allergy Clin Immunol"},{"key":"10.1111\/j.1365-2222.2011.03728.x-BIB24|cit24","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/sj.gene.6363935","article-title":"Insertion\/deletion coding polymorphisms in hHAVcr-1 are not associated with atopic asthma in the Japanese population","volume":"4","author":"Noguchi","year":"2003","journal-title":"Genes Immun"}],"container-title":["Clinical & Experimental Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2222.2011.03728.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/j.1365-2222.2011.03728.x\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,5]],"date-time":"2024-04-05T23:07:29Z","timestamp":1712358449000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2222.2011.03728.x"}},"subtitle":["Tim1 and Tim3 in lung allergy"],"short-title":[],"issued":{"date-parts":[[2011,4,7]]},"references-count":24,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2011,7]]}},"URL":"https:\/\/doi.org\/10.1111\/j.1365-2222.2011.03728.x","relation":{},"ISSN":["0954-7894"],"issn-type":[{"value":"0954-7894","type":"print"}],"subject":[],"published":{"date-parts":[[2011,4,7]]}}}