{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T14:24:27Z","timestamp":1761488667409},"reference-count":37,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2011,4,13]],"date-time":"2011-04-13T00:00:00Z","timestamp":1302652800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2011,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background\n\t\t\t\t\t<\/jats:bold> Epidemiologic studies have suggested that helminth infections play a protective role against allergy; this inverse association, however, has not been consistent. <jats:italic>Clonorchis sinensis<\/jats:italic>, the liver fluke of human, is prevalent in the Far East. The association between <jats:italic>C. sinensis<\/jats:italic> infection and allergy has not yet been reported.<\/jats:p><jats:p><jats:bold>Objective\n\t\t\t\t\t<\/jats:bold> We evaluated the association between clonorchiasis and atopy or allergic diseases in adults in endemic areas of clonorchiasis.<\/jats:p><jats:p><jats:bold>Methods\n\t\t\t\t\t<\/jats:bold> A total of 1116 subjects (males 419, females 697; age range, 30\u201386; mean age=61 years) were recruited from two endemic areas of <jats:italic>C. sinensis<\/jats:italic> in Korea. Clonorchiasis was confirmed by stool examination. Allergic symptoms were evaluated with a modified ISAAC questionnaire, and atopy was defined by skin prick test for common inhalant allergens. Total serum IgE and <jats:italic>C. sinensis<\/jats:italic>\u2010specific IgE level was measured by ELISA and methacholine bronchial provocation test was performed to evaluate airway hyperresponsiveness (AHR).<\/jats:p><jats:p><jats:bold>Results\n\t\t\t\t\t<\/jats:bold> Clonorchiasis was positively associated with atopy [odds ratio (OR), 1.856; 95% confidence interval (CI), 1.199\u20132.873] and high levels of total serum IgE (OR, 1.455; 95% CI, 1.050\u20132.016). Higher association with clonorchiasis was shown in subjects who showed both atopy and high total serum IgE levels (OR, 2.540; 95% CI, 1.448\u20134.455). Clonorchiasis had no association with wheezing, AHR, asthma or allergic rhinitis.<\/jats:p><jats:p><jats:bold>Conclusion and Clinical Relevance\n\t\t\t\t\t<\/jats:bold> Clonorchiasis was positively associated with atopy in adults in endemic area.<\/jats:p><jats:p> <jats:italic>Cite this as<\/jats:italic>: M\u2010H Choi, Y\u2010S Chang, M. K. Lim, Y. M. Bae, S\u2010T Hong, J\u2010K Oh, E. H. Yun, M\u2010J Bae, H\u2010S Kwon, S\u2010M Lee, H\u2010W Park, K\u2010U Min, Y\u2010Y Kim and S\u2010H Cho, <jats:italic>Clinical &amp; Experimental Allergy<\/jats:italic>, 2011 (41) 697\u2013705.<\/jats:p>","DOI":"10.1111\/j.1365-2222.2011.03746.x","type":"journal-article","created":{"date-parts":[[2011,4,14]],"date-time":"2011-04-14T02:25:55Z","timestamp":1302747955000},"page":"697-705","source":"Crossref","is-referenced-by-count":19,"title":["<i>Clonorchis sinensis<\/i> infection is positively associated with atopy in endemic area"],"prefix":"10.1111","volume":"41","author":[{"given":"M\u2010H","family":"Choi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y\u2010S","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. 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