{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T22:20:53Z","timestamp":1793485253514,"version":"4.5.0"},"reference-count":154,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2011,8,17]],"date-time":"2011-08-17T00:00:00Z","timestamp":1313539200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2011,9]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>This guidance for the management of patients with hymenoptera venom allergy has been prepared by the Standards of Care Committee (SOCC) of the British Society for Allergy and Clinical Immunology (BSACI). The guideline is based on evidence as well as on expert opinion and is for use by both adult physicians and pediatricians practising allergy. During the development of these guidelines, all BSACI members were included in the consultation process using a web\u2010based system. Their comments and suggestions were carefully considered by the SOCC. Where evidence was lacking, consensus was reached by the experts on the committee. Included in this guideline are epidemiology, risk factors, clinical features, diagnostic tests, natural history of hymenoptera venom allergy and guidance on undertaking venom immunotherapy (VIT). There are also separate sections on children, elevated baseline tryptase and mastocytosis and mechanisms underlying VIT. Finally, we have made recommendations for potential areas of future research.<\/jats:p>\n                  <jats:p>\n                    <jats:italic>Cite this as<\/jats:italic>\n                    : M. T. Krishna, P. W. Ewan, L. Diwakar, S. R. Durham, A. J. Frew, S. C. Leech and S. M. Nasser,\n                    <jats:italic>Clinical &amp; Experimental Allergy<\/jats:italic>\n                    , 2011 (41) 1201\u20131220.\n                  <\/jats:p>","DOI":"10.1111\/j.1365-2222.2011.03788.x","type":"journal-article","created":{"date-parts":[[2011,8,17]],"date-time":"2011-08-17T08:05:35Z","timestamp":1313568335000},"page":"1201-1220","source":"Crossref","is-referenced-by-count":157,"title":["Diagnosis and management of hymenoptera venom allergy: British Society for Allergy and Clinical Immunology (BSACI) guidelines"],"prefix":"10.1111","volume":"41","author":[{"given":"M. T.","family":"Krishna","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. W.","family":"Ewan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Diwakar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. R.","family":"Durham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. J.","family":"Frew","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. C.","family":"Leech","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. M.","family":"Nasser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,8,17]]},"reference":[{"issue":"3","key":"e_1_2_15_2_2","first-page":"1","article-title":"Position paper on allergen immunotherapy. Report of a BSACI working party. January\u2010October 1992","volume":"23","author":"BSACI working party.","year":"1993","journal-title":"Clin Exp Allergy"},{"key":"e_1_2_15_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00130832-200208000-00008"},{"key":"e_1_2_15_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2005.00963.x"},{"key":"e_1_2_15_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1989.03430020082033"},{"key":"e_1_2_15_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1997.tb02545.x"},{"key":"e_1_2_15_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1997.tb01056.x"},{"key":"e_1_2_15_8_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.1999.00614.x"},{"key":"e_1_2_15_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2005.02169.x"},{"key":"e_1_2_15_10_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.1998.00313.x"},{"key":"e_1_2_15_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2007.01588.x"},{"key":"e_1_2_15_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.all.0000173783.42906.95"},{"key":"e_1_2_15_13_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.2000.00864.x"},{"key":"e_1_2_15_14_2","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1002\/0470861193.ch10","article-title":"Fatal anaphylaxis in the UK, 1992\u20132001","volume":"257","author":"Pumphrey RS.","year":"2004","journal-title":"Novartis Found Symp"},{"key":"e_1_2_15_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1994.tb00796.x"},{"key":"e_1_2_15_16_2","first-page":"439","article-title":"Insect sting allergy and venom immunotherapy","volume":"115","author":"Golden DB.","year":"2005","journal-title":"a model and a mystery"},{"key":"e_1_2_15_17_2","doi-asserted-by":"publisher","DOI":"10.2500\/108854197778605518"},{"key":"e_1_2_15_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(94)90249-6"},{"key":"e_1_2_15_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2005.12.1313"},{"key":"e_1_2_15_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(82)80750-6"},{"key":"e_1_2_15_21_2","doi-asserted-by":"publisher","DOI":"10.1097\/ACI.0b013e328259c328"},{"key":"e_1_2_15_22_2","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1G295"},{"key":"e_1_2_15_23_2","first-page":"1047","article-title":"Predictors of severe systemic anaphylactic reactions in patients with Hymenoptera venom allergy","volume":"124","author":"Rueff F","year":"2009","journal-title":"importance of baseline serum tryptase-a study of the European Academy of Allergology and Clinical Immunology Interest Group on Insect Venom Hypersensitivity"},{"key":"e_1_2_15_24_2","first-page":"1216","article-title":"Elevated basal serum tryptase and hymenoptera venom allergy","volume":"33","author":"Haeberli G","year":"2003","journal-title":"relation to severity of sting reactions and to safety and efficacy of venom immunotherapy"},{"key":"e_1_2_15_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)03647-3"},{"key":"e_1_2_15_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2007.11.010"},{"key":"e_1_2_15_27_2","doi-asserted-by":"publisher","DOI":"10.1159\/000113520"},{"key":"e_1_2_15_28_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.all.0000136760.43571.f2"},{"key":"e_1_2_15_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(81)90148-2"},{"key":"e_1_2_15_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(82)80003-1"},{"key":"e_1_2_15_31_2","first-page":"304","article-title":"Allergens in hymenoptera venom. VI. Cross reactivity of human IgE antibodies to the three vespid venoms and between vespid and paper wasp venoms","volume":"46","author":"Hoffman DR.","year":"1981","journal-title":"Ann Allergy"},{"key":"e_1_2_15_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(82)90064-1"},{"key":"e_1_2_15_33_2","first-page":"707","article-title":"Allergens in Hymenoptera venom. XXV","volume":"92","author":"Hoffman DR.","year":"1993","journal-title":"the amino acid sequences of antigen 5 molecules and the structural basis of antigenic cross-reactivity"},{"key":"e_1_2_15_34_2","first-page":"588","article-title":"Yellow jacket venom allergens, hyaluronidase and phospholipase","volume":"98","author":"King TP","year":"1996","journal-title":"sequence similarity and antigenic cross-reactivity with their hornet and wasp homologs and possible implications for clinical allergy"},{"key":"e_1_2_15_35_2","first-page":"60","article-title":"Analysis of differing patterns of cross\u2010reactivity of honeybee and yellow jacket venom\u2010specific IgE","volume":"89","author":"Wypych JI","year":"1989","journal-title":"use of purified venom fractions"},{"key":"e_1_2_15_36_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2007.01353.x"},{"key":"e_1_2_15_37_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1998.tb03973.x"},{"key":"e_1_2_15_38_2","first-page":"812","article-title":"Allergens in Hymenoptera venom. XXVII","volume":"97","author":"Hoffman DR","year":"1996","journal-title":"bumblebee venom allergy and allergens"},{"key":"e_1_2_15_39_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.1998.00176.x"},{"key":"e_1_2_15_40_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00105-008-1485-3"},{"key":"e_1_2_15_41_2","first-page":"1220","article-title":"In vitro hymenoptera venom allergy diagnosis","volume":"61","author":"Jappe U","year":"2006","journal-title":"improved by screening for cross-reactive carbohydrate determinants and reciprocal inhibition"},{"key":"e_1_2_15_42_2","first-page":"543","article-title":"Hymenoptera venom allergy","volume":"64","author":"Muller UR","year":"2009","journal-title":"analysis of double positivity to honey bee and Vespula venom by estimation of IgE antibodies to species-specific major allergens Api m1 and Ves v5"},{"key":"e_1_2_15_43_2","first-page":"334","article-title":"Large local reactions from stinging insects","volume":"9","author":"Severino M","year":"2009","journal-title":"from epidemiology to management"},{"key":"e_1_2_15_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(84)90384-1"},{"key":"e_1_2_15_45_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197807272990401"},{"key":"e_1_2_15_46_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199012063232305"},{"key":"e_1_2_15_47_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.1979.tb02497.x"},{"key":"e_1_2_15_48_2","first-page":"735","article-title":"Stinging insect allergy","volume":"75","author":"Reisman RE","year":"1985","journal-title":"natural history and modification with venom immunotherapy"},{"key":"e_1_2_15_49_2","first-page":"E8","article-title":"Anaphylaxis in children","volume":"101","author":"Novembre E","year":"1998","journal-title":"clinical and allergologic features"},{"key":"e_1_2_15_50_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1970.tb01264.x"},{"key":"e_1_2_15_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(73)90044-4"},{"key":"e_1_2_15_52_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2007.01413.x"},{"key":"e_1_2_15_53_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMe048168"},{"key":"e_1_2_15_54_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003226-200204000-00019"},{"key":"e_1_2_15_55_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.235.19.2120"},{"key":"e_1_2_15_56_2","first-page":"772","article-title":"Nearly fatal case of Schoenlein\u2013Henoch syndrome following insect bite","volume":"88","author":"Burke DM","year":"1954","journal-title":"AMA Am J Dis Child"},{"key":"e_1_2_15_57_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2003.10.025"},{"key":"e_1_2_15_58_2","doi-asserted-by":"publisher","DOI":"10.2500\/108854189778961035"},{"key":"e_1_2_15_59_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.284.6308.20"},{"key":"e_1_2_15_60_2","doi-asserted-by":"publisher","DOI":"10.1081\/CLT-120026527"},{"key":"e_1_2_15_61_2","first-page":"157","article-title":"Diffuse alveolar haemorrhage","volume":"7","author":"Mukhopadhyay A","year":"2002","journal-title":"a rare reaction to insect sting"},{"key":"e_1_2_15_62_2","first-page":"229","article-title":"Severe thrombocytopenic purpura following a bee sting","volume":"49","author":"Tanphaichitr VS","year":"1982","journal-title":"Ann Allergy"},{"key":"e_1_2_15_63_2","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(94)90351-4"},{"key":"e_1_2_15_64_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-85-1-56"},{"key":"e_1_2_15_65_2","first-page":"427","article-title":"Allergy to stinging insects","volume":"70","author":"Valentine MD.","year":"1993","journal-title":"Ann Allergy"},{"key":"e_1_2_15_66_2","first-page":"49","article-title":"Position Paper","volume":"48","author":"Dreborg S","year":"1993","journal-title":"allergen standardization and skin tests"},{"key":"e_1_2_15_67_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.11.018"},{"key":"e_1_2_15_68_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.02.003"},{"key":"e_1_2_15_69_2","first-page":"717","article-title":"Cutaneous manifestations in Hymenoptera and Diptera anaphylaxis","volume":"39","author":"Potier A","year":"2009","journal-title":"relationship with basal serum tryptase"},{"key":"e_1_2_15_70_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2007.10.014"},{"key":"e_1_2_15_71_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2007.01413.x"},{"key":"e_1_2_15_72_2","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.b.20142"},{"key":"e_1_2_15_73_2","first-page":"1102","article-title":"The basophil activation test in wasp venom allergy","volume":"59","author":"Erdmann SM","year":"2004","journal-title":"sensitivity, specificity and monitoring specific immunotherapy"},{"key":"e_1_2_15_74_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.2000.00863.x"},{"key":"e_1_2_15_75_2","first-page":"1110","article-title":"The CD63 basophil activation test in Hymenoptera venom allergy","volume":"59","author":"Sturm GJ","year":"2004","journal-title":"a prospective study"},{"key":"e_1_2_15_76_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2005.00894.x"},{"key":"e_1_2_15_77_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2006.01099.x"},{"key":"e_1_2_15_78_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.1987.tb02037.x"},{"key":"e_1_2_15_79_2","first-page":"116","article-title":"Detection of IgE antibody to venom antigens by Western blotting in patients with negative RAST","volume":"48","author":"Ewan P","year":"1993","journal-title":"Allergy"},{"key":"e_1_2_15_80_2","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2001.114706"},{"key":"e_1_2_15_81_2","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(80)90047-0"},{"key":"e_1_2_15_82_2","first-page":"337","article-title":"Allergens in Hymenoptera venom. XVI","volume":"78","author":"Hoffman DR.","year":"1986","journal-title":"studies of the structures and cross-reactivities of vespid venom phospholipases"},{"key":"e_1_2_15_83_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1991.tb00553.x"},{"key":"e_1_2_15_84_2","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(93)90007-3"},{"key":"e_1_2_15_85_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1979.tb02006.x"},{"key":"e_1_2_15_86_2","first-page":"351","article-title":"Venom immunotherapy","volume":"45","author":"Gillman SA","year":"1980","journal-title":"comparison of \u201crush\u201d vs \u201cconventional\u201d schedules"},{"key":"e_1_2_15_87_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1986.tb00284.x"},{"key":"e_1_2_15_88_2","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(92)90319-W"},{"key":"e_1_2_15_89_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1129317"},{"key":"e_1_2_15_90_2","first-page":"119","article-title":"Results of hyposensitization with bee and wasp venom","volume":"166","author":"Adolph J","year":"1986","journal-title":"Z Erkr Atmungsorgane"},{"key":"e_1_2_15_91_2","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2002.125827"},{"key":"e_1_2_15_92_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2009.03230.x"},{"key":"e_1_2_15_93_2","first-page":"435","article-title":"Adverse reactions to venom immunotherapy","volume":"47","author":"Ramirez DA","year":"1981","journal-title":"Ann Allergy"},{"key":"e_1_2_15_94_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(80)80470-7"},{"key":"e_1_2_15_95_2","first-page":"775","article-title":"The Hymenoptera venom study. III","volume":"86","author":"Lockey RF","year":"1990","journal-title":"safety of venom immunotherapy"},{"key":"e_1_2_15_96_2","first-page":"81","article-title":"Immunotherapy with aluminum hydroxide adsorbed insect venom extracts (Alutard SQ)","volume":"48","author":"Wyss M","year":"1993","journal-title":"immunologic and clinical results of a prospective study over 3 years"},{"key":"e_1_2_15_97_2","first-page":"1651","article-title":"Practice of venom immunotherapy in the United Kingdom","volume":"38","author":"Diwakar L","year":"2008","journal-title":"a national audit and review of literature"},{"key":"e_1_2_15_98_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1997.tb02551.x"},{"key":"e_1_2_15_99_2","first-page":"928","article-title":"Rush Hymenoptera venom immunotherapy","volume":"110","author":"Sturm G","year":"2002","journal-title":"a safe and practical protocol for high-risk patients"},{"key":"e_1_2_15_100_2","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2000.105708"},{"key":"e_1_2_15_101_2","first-page":"58","article-title":"Hymenoptera ultra\u2010rush venom immunotherapy (210\u2003min)","volume":"33","author":"Birnbaum J","year":"2003","journal-title":"a safety study and risk factors"},{"key":"e_1_2_15_102_2","first-page":"484","article-title":"Reduction of side\u2010effects from ultrarush immunotherapy with honeybee venom by pretreatment with fexofenadine","volume":"55","author":"Reimers A","year":"2000","journal-title":"a double-blind, placebo-controlled trial"},{"key":"e_1_2_15_103_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.1992.tb00115.x"},{"key":"e_1_2_15_104_2","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(89)90394-1"},{"key":"e_1_2_15_105_2","first-page":"423","article-title":"Rapid venom immunotherapy is safe for routine use in the treatment of patients with Hymenoptera anaphylaxis","volume":"73","author":"Bernstein JA","year":"1994","journal-title":"Ann Allergy"},{"key":"e_1_2_15_106_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-92-5-620"},{"key":"e_1_2_15_107_2","first-page":"226","article-title":"Rapid Hymenoptera venom immunotherapy","volume":"23","author":"Birnbaum J","year":"1993","journal-title":"comparative safety of three protocols"},{"key":"e_1_2_15_108_2","first-page":"1005","article-title":"Side\u2010effects of insect venom immunotherapy","volume":"55","author":"Mosbech H","year":"2000","journal-title":"results from an EAACI multicenter study. European Academy of Allergology and Clinical Immunology"},{"key":"e_1_2_15_109_2","first-page":"1459","article-title":"Prevention and treatment of hymenoptera venom allergy","volume":"60","author":"Bonifazi F","year":"2005","journal-title":"guidelines for clinical practice"},{"key":"e_1_2_15_110_2","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2001.119154"},{"key":"e_1_2_15_111_2","first-page":"458","article-title":"Efficacy of antihistamine pretreatment in the prevention of adverse reactions to Hymenoptera immunotherapy","volume":"100","author":"Brockow K","year":"1997","journal-title":"a prospective, randomized, placebo-controlled trial"},{"key":"e_1_2_15_112_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.08.007"},{"key":"e_1_2_15_113_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-115-4-270"},{"key":"e_1_2_15_114_2","first-page":"S25","article-title":"Allergen immunotherapy","volume":"120","year":"2007","journal-title":"a practice parameter second update"},{"key":"e_1_2_15_115_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2004.11.012"},{"key":"e_1_2_15_116_2","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(88)90949-9"},{"key":"e_1_2_15_117_2","doi-asserted-by":"publisher","DOI":"10.1136\/emj.2005.023507"},{"key":"e_1_2_15_118_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(03)01940-7"},{"key":"e_1_2_15_119_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)60321-3"},{"key":"e_1_2_15_120_2","first-page":"963","article-title":"Beekeepers anaphylaxis","volume":"62","author":"Schulze J","year":"2007","journal-title":"successful immunotherapy covered by omalizumab"},{"key":"e_1_2_15_121_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2007.01604.x"},{"key":"e_1_2_15_122_2","first-page":"1237","article-title":"Mastocytosis and insect venom allergy","volume":"64","author":"Niedoszytko M","year":"2009","journal-title":"diagnosis, safety and efficacy of venom immunotherapy"},{"key":"e_1_2_15_123_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(00)90092-7"},{"key":"e_1_2_15_124_2","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(91)90391-Z"},{"key":"e_1_2_15_125_2","first-page":"606","article-title":"Long\u2010term protection after stopping venom immunotherapy","volume":"101","author":"Lerch E","year":"1998","journal-title":"results of re-stings in 200 patients"},{"key":"e_1_2_15_126_2","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2001.115095"},{"key":"e_1_2_15_127_2","doi-asserted-by":"publisher","DOI":"10.1097\/00130832-200308000-00008"},{"key":"e_1_2_15_128_2","first-page":"18","article-title":"Bee\u2010venom allergy in children","volume":"13","author":"Schuetze GE","year":"2002","journal-title":"long-term predictive value of standardized challenge tests"},{"key":"e_1_2_15_129_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(97)70314-2"},{"issue":"1","key":"e_1_2_15_130_2","first-page":"69","article-title":"Fatal outcome of a Vespula sting in a patient with mastocytosis after specific immunotherapy with honey bee venom","volume":"17","author":"Reimers A","year":"2005","journal-title":"Allergy Clin Immunol Int J WAO Org"},{"key":"e_1_2_15_131_2","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2001.114985"},{"key":"e_1_2_15_132_2","first-page":"148","article-title":"A modified ultrarush insect venom immunotherapy protocol for children","volume":"27","author":"Steiss JO","year":"2006","journal-title":"Allergy Asthma Proc"},{"key":"e_1_2_15_133_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.all.0000011041.90910.f2"},{"key":"e_1_2_15_134_2","first-page":"603","article-title":"IL\u201010\u2010induced anergy in peripheral T cell and reactivation by microenvironmental cytokines","volume":"13","author":"Akdis CA","year":"1999","journal-title":"two key steps in specific immunotherapy"},{"key":"e_1_2_15_135_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI2250"},{"key":"e_1_2_15_136_2","doi-asserted-by":"publisher","DOI":"10.1002\/1521-4141(200112)31:12<3704::AID-IMMU3704>3.0.CO;2-3"},{"key":"e_1_2_15_137_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.5.3252"},{"key":"e_1_2_15_138_2","first-page":"1666","article-title":"A molecular basis for T cell suppression by IL\u201010","volume":"14","author":"Akdis CA","year":"2000","journal-title":"CD28-associated IL-10 receptor inhibits CD28 tyrosine phosphorylation and phosphatidylinositol 3-kinase binding"},{"key":"e_1_2_15_139_2","doi-asserted-by":"publisher","DOI":"10.1002\/1521-4141(200006)30:6<1683::AID-IMMU1683>3.0.CO;2-A"},{"key":"e_1_2_15_140_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830270513"},{"key":"e_1_2_15_141_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830260612"},{"key":"e_1_2_15_142_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.2001.01069.x"},{"key":"e_1_2_15_143_2","first-page":"647","article-title":"Venom\u2010specific IgG antibodies in bee and wasp allergy","volume":"23","author":"Ewan PW","year":"1993","journal-title":"lack of correlation with protection from stings"},{"key":"e_1_2_15_144_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1994.tb02660.x"},{"key":"e_1_2_15_145_2","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(85)90029-6"},{"key":"e_1_2_15_146_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.2000.00412.x"},{"key":"e_1_2_15_147_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1988.tb00902.x"},{"key":"e_1_2_15_148_2","first-page":"317","article-title":"Provocation test with a living insect as a diagnostic tool in systemic reactions to bee and wasp venom","volume":"17","author":"Kampelmacher MJ","year":"1987","journal-title":"a prospective study with emphasis on the clinical aspects"},{"key":"e_1_2_15_149_2","first-page":"200","article-title":"Evaluation of Hymenoptera\u2010sting sensitivity with deliberate sting challenges","volume":"69","author":"Parker JL","year":"1982","journal-title":"inadequacy of present diagnostic methods"},{"key":"e_1_2_15_150_2","first-page":"741","article-title":"Studies of the natural history of stinging\u2010insect allergy","volume":"80","author":"Savliwala MN","year":"1987","journal-title":"long-term follow-up of patients without immunotherapy"},{"key":"e_1_2_15_151_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(83)80649-0"},{"key":"e_1_2_15_152_2","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(89)90387-4"},{"issue":"1","key":"e_1_2_15_153_2","first-page":"82","article-title":"A prospective study of systemic reactions to venom immunotherapy (VIT)","volume":"23","author":"Ewan PW","year":"1993","journal-title":"Clin Exp Allergy"},{"key":"e_1_2_15_154_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.1995.tb01021.x"},{"key":"e_1_2_15_155_2","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2001.111852"}],"container-title":["Clinical &amp; Experimental Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2222.2011.03788.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2222.2011.03788.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T13:01:24Z","timestamp":1694523684000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2222.2011.03788.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,8,17]]},"references-count":154,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2011,9]]}},"alternative-id":["10.1111\/j.1365-2222.2011.03788.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2222.2011.03788.x","archive":["Portico"],"relation":{},"ISSN":["0954-7894","1365-2222"],"issn-type":[{"value":"0954-7894","type":"print"},{"value":"1365-2222","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,8,17]]}}}