{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T14:31:40Z","timestamp":1783780300876,"version":"3.55.0"},"reference-count":34,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2011,6,16]],"date-time":"2011-06-16T00:00:00Z","timestamp":1308182400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2011,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>\n            <jats:bold>Background <\/jats:bold> Chronic rhinosinusitis with nasal polyposis (CRSwNP) represents an interesting model to investigate the existence of a non\u2010allergic unified airway. The factors associated with airway dysfunction in CRSwNP are not fully understood.<\/jats:p><jats:p>\n            <jats:bold>Objective <\/jats:bold> To assess the impact of nasal disease on lower airway dysfunction in CRSwNP.<\/jats:p><jats:p>\n            <jats:bold>Methods <\/jats:bold> Fifty\u2010seven patients with CRSwNP underwent spirometry, nasal endoscopy, exhaled nitric oxide, methacholine bronchial challenge, blood sampling for total IgE, eosinophil count and radioallergosorbent testing (NCT00788749). Three phenotypic groups were identified: \u2018asthma group\u2019 (asthma diagnosis); \u2018inflammatory group\u2019 [no asthma diagnosis, but elevated fractionated exhaled nitric oxide (FE<jats:sub>NO<\/jats:sub>) and\/or bronchial\u2010hyperreactivity (BHR)]; and \u2018non\u2010inflammatory group\u2019 (no asthma diagnosis, no BHR and normal FE<jats:sub>NO<\/jats:sub>). Group comparisons, univariate and multivariate analyses were performed to examine associations with airway dysfunction.<\/jats:p><jats:p>\n            <jats:bold>Results <\/jats:bold> FEV<jats:sub>1<\/jats:sub> and FEF<jats:sub>25\u221275%<\/jats:sub> were reduced in asthma, but there was no difference between the non\u2010asthmatic groups. Total IgE and eosinophils were elevated in asthma vs. the non\u2010inflammatory group, but there was no difference for asthma vs. inflammatory groups. BHR was the only significant predictor of FEV<jats:sub>1<\/jats:sub> (<jats:italic>P<\/jats:italic>&lt;0.001). For FEF<jats:sub>25\u221275<\/jats:sub>, BHR and eosinophil count were independent predictors (<jats:italic>P<\/jats:italic>&lt;0.001 and <jats:italic>P<\/jats:italic>=0.04). Nasal outcomes were not predictors of spirometry.<\/jats:p><jats:p>\n            <jats:bold>Conclusion and Clinical Relevance <\/jats:bold> In CRSwNP there is asymptomatic airway dysfunction suggestive of an asthmatic phenotype. Impairment of lung function is significantly associated with BHR and eosinophilia but not parameters of nasal disease suggesting that severity of airway dysfunction relates to the spectrum of asthma rather than rhinosinusitis. Lower airway dysfunction is common in CRSwNP but does not correlate to the severity of nasal disease. Signs and symptoms of asthma should be sought and treated in CRSwNP.<\/jats:p><jats:p>\n            <jats:italic>Cite this as<\/jats:italic>: P. A. Williamson, S. Vaidyanathan, K. Clearie, M. Barnes and B. J. Lipworth, <jats:italic>Clinical &amp; Experimental Allergy<\/jats:italic>, 2011 (41) 1379\u20131385.<\/jats:p>","DOI":"10.1111\/j.1365-2222.2011.03793.x","type":"journal-article","created":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T16:55:17Z","timestamp":1308329717000},"page":"1379-1385","source":"Crossref","is-referenced-by-count":33,"title":["Airway dysfunction in nasal polyposis: a spectrum of asthmatic disease?"],"prefix":"10.1111","volume":"41","author":[{"given":"P. A.","family":"Williamson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Vaidyanathan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Clearie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Barnes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. J.","family":"Lipworth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,6,16]]},"reference":[{"issue":"84","key":"e_1_2_7_2_2","first-page":"1","article-title":"Common characteristics of upper and lower airways in rhinitis and asthma","volume":"62","author":"Cruz AA","year":"2007","journal-title":"ARIA update, in collaboration with GA(2)LEN"},{"key":"e_1_2_7_3_2","first-page":"1048","article-title":"The link between allergic rhinitis and allergic asthma","volume":"57","author":"Linneberg A","year":"2002","journal-title":"a prospective population-based study. The Copenhagen Allergy Study"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2005.00659.x"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1997.tb00999.x"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.moo.0000193186.15440.39"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.161.6.9906121"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.164.5.2006082"},{"key":"e_1_2_7_9_2","first-page":"1049","article-title":"Rhinitis and onset of asthma","volume":"372","author":"Shaaban R","year":"2008","journal-title":"a longitudinal population-based study"},{"key":"e_1_2_7_10_2","first-page":"292","article-title":"Frequency and impact of allergic rhinitis in asthma patients in everyday general medical practice","volume":"63","author":"Magnan A","year":"2008","journal-title":"a French observational cross-sectional study"},{"key":"e_1_2_7_11_2","first-page":"21","article-title":"Long\u2010term risk factors for developing asthma and allergic rhinitis","volume":"15","author":"Settipane RJ","year":"1994","journal-title":"a 23-year follow-up study of college students"},{"key":"e_1_2_7_12_2","first-page":"255","article-title":"Impact of allergic rhinitis on asthma","volume":"63","author":"Ciprandi G","year":"2008","journal-title":"effects on spirometric parameters"},{"key":"e_1_2_7_13_2","first-page":"790","article-title":"United airways again","volume":"64","author":"Guilemany JM","year":"2009","journal-title":"high prevalence of rhinosinusitis and nasal polyps in bronchiectasis"},{"key":"e_1_2_7_14_2","first-page":"261","article-title":"Sinonasal pathology in nonallergic asthma and COPD","volume":"63","author":"Hens G","year":"2008","journal-title":"\u2018united airway disease\u2019 beyond the scope of allergy"},{"key":"e_1_2_7_15_2","first-page":"1","article-title":"European position paper on rhinosinusitis and nasal polyps 2007","volume":"20","author":"Fokkens W","year":"2007","journal-title":"Rhinol Suppl"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.2500\/108854196778662255"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.161.2.9905075"},{"key":"e_1_2_7_18_2","first-page":"26","article-title":"Efficacy of topical corticosteroid powder for nasal polyps","volume":"20","author":"Lildholdt T","year":"1995","journal-title":"a double-blind, placebo-controlled study of budesonide"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.161.1.ats11-99"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00034805"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00035005"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200406-710ST"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2008.03006.x"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.51.5.496"},{"key":"e_1_2_7_25_2","first-page":"1286","article-title":"Airway eosinophilia in children with severe asthma","volume":"174","author":"Lex C","year":"2006","journal-title":"predictive values of noninvasive tests"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.53.2.91"},{"key":"e_1_2_7_27_2","first-page":"1115","article-title":"Stepping down inhaled corticosteroids in asthma","volume":"326","author":"Hawkins G","year":"2003","journal-title":"randomised controlled trial"},{"key":"e_1_2_7_28_2","first-page":"1852","article-title":"Fraction of exhaled nitric oxide at 50\u2003mL\/s","volume":"131","author":"Olin AC","year":"2007","journal-title":"reference values for adult lifelong never-smokers"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200609-1346OC"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.2500\/ajr.2006.20.2914"},{"key":"e_1_2_7_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2005.03.030"},{"key":"e_1_2_7_32_2","doi-asserted-by":"publisher","DOI":"10.2500\/aap.2007.28.2920"},{"key":"e_1_2_7_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2004.11.010"},{"key":"e_1_2_7_34_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2004.2262.x"},{"key":"e_1_2_7_35_2","first-page":"319","article-title":"Airway inflammation in nasal polyposis","volume":"35","author":"Ediger D","year":"2005","journal-title":"immunopathological aspects of relation to asthma"}],"container-title":["Clinical &amp; Experimental Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2222.2011.03793.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2222.2011.03793.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T12:26:41Z","timestamp":1695472001000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2222.2011.03793.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,6,16]]},"references-count":34,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2011,10]]}},"alternative-id":["10.1111\/j.1365-2222.2011.03793.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2222.2011.03793.x","archive":["Portico"],"relation":{},"ISSN":["0954-7894","1365-2222"],"issn-type":[{"value":"0954-7894","type":"print"},{"value":"1365-2222","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,6,16]]}}}