{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T17:50:13Z","timestamp":1781027413472,"version":"3.54.1"},"reference-count":26,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T00:00:00Z","timestamp":1314835200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2011,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>During a systemic hypersensitivity reaction (<jats:styled-content style=\"fixed-case\">SR<\/jats:styled-content>), an increase in serum tryptase compared to the baseline value is an indicator of mast cell activation, most often due to an <jats:styled-content style=\"fixed-case\">IgE<\/jats:styled-content>\u2010mediated mechanism.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To study the relevance of an increase in serum tryptase below the upper normal value of 11.4\u00a0ng\/mL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Serum tryptase levels were measured in 35 patients with <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>ymenoptera venom hypersensitivity before and during venom exposure. Of these, 20 developed <jats:styled-content style=\"fixed-case\">SR<\/jats:styled-content> to stings or following venom injections during immunotherapy (reactors), while 15 tolerated reexposure to stings or venom injections during immunotherapy without <jats:styled-content style=\"fixed-case\">SR<\/jats:styled-content> (non\u2010reactors). Serum tryptase was estimated at 2, 5 and 24\u00a0h after exposure and was compared to a baseline value obtained before or at least 72\u00a0h after exposure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Considering circadian variation of serum tryptase, a relative increase to \u2265135% of the baseline value (relative delta bound) was defined to indicate mast cell activation. Such an increase was observed in 17 of 20 reactors (85%), but none of 15 non\u2010reactors. A serum tryptase of \u226511.4\u00a0ng\/mL following venom exposure was observed in eight of the 20 reactors (40%) and 2 (13.3%) of the 15 non\u2010reactors. Both these non\u2010reactors also had an elevated baseline serum tryptase.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Clinical Relevance<\/jats:title><jats:p>Serum tryptase values obtained during a suspected hypersensitivity reaction must always be compared to a baseline value. A relative tryptase increase to \u2265135% of the baseline value during a suspected hypersensitivity reaction indicates mast cell activation even below 11.4\u00a0ng\/mL.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1365-2222.2011.03848.x","type":"journal-article","created":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T18:31:10Z","timestamp":1314901870000},"page":"1777-1783","source":"Crossref","is-referenced-by-count":65,"title":["An increase in serum tryptase even below 11.4\u00a0ng\/mL may indicate a mast cell\u2010mediated hypersensitivity reaction: a prospective study in <scp>H<\/scp>ymenoptera venom allergic patients"],"prefix":"10.1111","volume":"41","author":[{"given":"M.","family":"Borer\u2010Reinhold","sequence":"first","affiliation":[{"name":"Allergiestation Medizinische Klinik Spital Netz Bern Ziegler Bern Switzerland"},{"name":"Allergologisch\u2010Immunologisch Poliklinik Klinik f\u00fcr Rheumatologie, Immunologie und Allergologie Universit\u00e4tspital Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Haeberli","sequence":"additional","affiliation":[{"name":"Allergiestation Medizinische Klinik Spital Netz Bern Ziegler Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Bitzenhofer","sequence":"additional","affiliation":[{"name":"Allergiestation Medizinische Klinik Spital Netz Bern Ziegler Bern Switzerland"},{"name":"Allergologisch\u2010Immunologisch Poliklinik Klinik f\u00fcr Rheumatologie, Immunologie und Allergologie Universit\u00e4tspital Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Jandus","sequence":"additional","affiliation":[{"name":"Allergiestation Medizinische Klinik Spital Netz Bern Ziegler Bern Switzerland"},{"name":"Allergologisch\u2010Immunologisch Poliklinik Klinik f\u00fcr Rheumatologie, Immunologie und Allergologie Universit\u00e4tspital Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Hausmann","sequence":"additional","affiliation":[{"name":"Allergiestation Medizinische Klinik Spital Netz Bern Ziegler Bern Switzerland"},{"name":"Allergologisch\u2010Immunologisch Poliklinik Klinik f\u00fcr Rheumatologie, Immunologie und Allergologie Universit\u00e4tspital Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Fricker","sequence":"additional","affiliation":[{"name":"Allergologisch\u2010Immunologisch Poliklinik Klinik f\u00fcr Rheumatologie, Immunologie und Allergologie Universit\u00e4tspital Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Helbling","sequence":"additional","affiliation":[{"name":"Allergiestation Medizinische Klinik Spital Netz Bern Ziegler Bern Switzerland"},{"name":"Allergologisch\u2010Immunologisch Poliklinik Klinik f\u00fcr Rheumatologie, Immunologie und Allergologie Universit\u00e4tspital Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U.","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Allergiestation Medizinische Klinik Spital Netz Bern Ziegler Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,9]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"crossref","first-page":"2184","DOI":"10.4049\/jimmunol.138.7.2184","article-title":"Evaluations of human peripheral blood leukocytes for mast cell tryptase","volume":"138","author":"Castells MC","year":"1987","journal-title":"J Immunol"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2004.02.032"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.iac.2006.05.010"},{"key":"e_1_2_6_5_1","volume-title":"ImmunoCAP tryptase. 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