{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T06:49:44Z","timestamp":1791096584926,"version":"4.1.0"},"reference-count":48,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,1,30]],"date-time":"2012-01-30T00:00:00Z","timestamp":1327881600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2012,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Determinants of wheezing severity are poorly documented in infants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To study the determinants of wheezing severity in infants aged 18\u00a0months followed\u2010up in the <jats:styled-content style=\"fixed-case\">PARIS<\/jats:styled-content> (\u00ab\u00a0Pollution and Asthma Risk\u00a0: an Infant Study\u00a0\u00bb) birth cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data on wheezing disorders, medical visits and medications, as well as biological markers of atopy, were collected during a medical examination at age 18\u00a0months. Severe wheeze was defined as wheeze that required inhaled corticosteroid and\/or hospital\u2010based care. Environmental exposures were assessed prospectively with regular questionnaires. Risk factors for wheeze in the first 18\u00a0months of life were assessed by multivariate regression models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Participation in the medical examination concerned 48.2% of the original cohort. Prevalence of wheeze was 560\/1879 (35.7%) and was influenced by male gender, parental history of asthma, siblings, daycare attendance, heavy parental smoking at home, and carpet covered floor in the child's bedroom. Being overweight increased the risk of wheeze by 62% (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a01.62, 95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.13\u20132.32). In addition, trends towards an increased risk of wheeze were found in infants exposed to daily use of cleaning sprays and to renovation activities. Conversely, the presence of a cat reduced the risk of wheeze (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a00.65, 95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.47\u20130.89), without any evidence of healthy\u2010pet keeping effect. Severe wheeze concerned 286 of the wheezers (42.7%). The prevalence of severe wheeze was related to atopy, and risk of severe wheeze was in particular increased in infants having eosinophilia (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a01.76, 95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.21\u20132.55) or being sensitized to \u2265\u00a02 allergens (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a01.88, 95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.13\u20133.14).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Clinical Relevance<\/jats:title><jats:p>Whilst risk factors for wheeze before 18\u00a0months of age are factors related to infections, indoor air pollution, and being overweight, the severity of wheeze is mainly due to the atopic status of the child. We suggest that atopy should be further considered in the assessment of wheezing severity in infants.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1365-2222.2011.03933.x","type":"journal-article","created":{"date-parts":[[2012,1,30]],"date-time":"2012-01-30T16:35:12Z","timestamp":1327941312000},"page":"275-283","source":"Crossref","is-referenced-by-count":45,"title":["Influence of host and environmental factors on wheezing severity in infants: findings from the <scp>PARIS<\/scp> birth cohort"],"prefix":"10.1111","volume":"42","author":[{"given":"M.","family":"Herr","sequence":"first","affiliation":[{"name":"Univ Paris Descartes Sorbonne Paris Cit\u00e9 Laboratoire Sant\u00e9 Publique et Environnement Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Just","sequence":"additional","affiliation":[{"name":"Univ Paris Descartes Sorbonne Paris Cit\u00e9 Laboratoire Sant\u00e9 Publique et Environnement Paris, France"},{"name":"Centre de l'Asthme et des Allergies Groupe Hospitalier Trousseau\u2010La Roche Guyon Assistance Publique \u2013 H\u00f4pitaux de Paris Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Nikasinovic","sequence":"additional","affiliation":[{"name":"Univ Paris Descartes Sorbonne Paris Cit\u00e9 Laboratoire Sant\u00e9 Publique et Environnement Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Foucault","sequence":"additional","affiliation":[{"name":"Centre d'Examens de Sant\u00e9 de l'Enfant Amelot CPAM de Paris Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.\u2010M.","family":"Le Marec","sequence":"additional","affiliation":[{"name":"Cellule Cohorte de la Direction de l'Action Sociale de l'Enfance et de la Sant\u00e9 de la Mairie de Paris Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.\u2010P.","family":"Giordanella","sequence":"additional","affiliation":[{"name":"Centre d'Examens de Sant\u00e9 de l'Enfant Amelot CPAM de Paris Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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