{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T11:18:07Z","timestamp":1790939887830,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2012,6,15]],"date-time":"2012-06-15T00:00:00Z","timestamp":1339718400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2012,7]]},"abstract":"Summary<\/jats:title>\n \n Background<\/jats:title>\n \n Using a double blind randomized placebo\u2010controlled trial (\n A<\/jats:styled-content>\n ustralian\n N<\/jats:styled-content>\n ew\n Z<\/jats:styled-content>\n ealand\n C<\/jats:styled-content>\n linical\n T<\/jats:styled-content>\n rials\n R<\/jats:styled-content>\n egistry:\n ACTRN<\/jats:styled-content>\n 12607000518460), we have shown that in a high risk birth cohort, maternal supplementation from 35\u00a0weeks gestation until 6\u00a0months if breastfeeding and infant supplementation until 2\u00a0years with\n Lactobacillus rhamnosus<\/jats:italic>\n HN<\/jats:styled-content>\n 001 (\n HN<\/jats:styled-content>\n 001) (6\u00a0\u00d7\u00a010\n 9<\/jats:sup>\n \u00a0cfu\/day) halved the cumulative prevalence of eczema by age 2\u00a0years.\n Bifidobacterium animalis<\/jats:italic>\n subsp\n lactis<\/jats:italic>\n HN<\/jats:styled-content>\n 019 (\n HN<\/jats:styled-content>\n 019) (9\u00a0\u00d7\u00a010\n 9<\/jats:sup>\n \u00a0cfu\/day) had no effect.\n <\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n \n The aim of this study was to investigate the associations of\n HN<\/jats:styled-content>\n 001 and\n HN<\/jats:styled-content>\n 019 with allergic disease and atopic sensitization among these children at age 4\u00a0years, 2\u00a0years after stopping probiotic supplementation.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n The presence (\n UK W<\/jats:styled-content>\n orking\n P<\/jats:styled-content>\n arty's\n D<\/jats:styled-content>\n iagnostic\n C<\/jats:styled-content>\n riteria) and severity\n SCOR<\/jats:styled-content>\n ing\n A<\/jats:styled-content>\n topic\n D<\/jats:styled-content>\n ermatitis (\n SCORAD<\/jats:styled-content>\n ) of eczema and atopy (skin prick tests) and parent\u2010reported symptoms of asthma and rhinoconjunctivitis were assessed using standard protocols and questions.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Four\u2010hundred and seventy\u2010four infants were eligible at birth of whom 425 (90%) participated in this follow\u2010up. The cumulative prevalence of eczema by 4\u00a0years (Hazard ratio (\n HR<\/jats:styled-content>\n ) 0.57 (95%\n CI<\/jats:styled-content>\n 0.39\u20130.83)) and prevalence of rhinoconjunctivitis at 4\u00a0years (Relative risk 0.38 (95%\n CI<\/jats:styled-content>\n 0.18\u20130.83)) were significantly reduced in the children taking\n HN<\/jats:styled-content>\n 001; there were also nonsignificant reductions in the cumulative prevalence of\n SCORAD<\/jats:styled-content>\n \u2265\u00a010 (\n HR<\/jats:styled-content>\n 0.74 (95%\n CI<\/jats:styled-content>\n 0.52\u20131.05), wheeze (\n HR<\/jats:styled-content>\n 0.79 (95%\n CI<\/jats:styled-content>\n 0.59\u20131.07)) and atopic sensitization (\n HR<\/jats:styled-content>\n \u00a0=\u00a00.72 (95%\n CI<\/jats:styled-content>\n 0.48\u20131.06)).\n HN<\/jats:styled-content>\n 019 did not affect the prevalence of any outcome.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions and Clinical Relevance<\/jats:title>\n \n This study showed that the protective effect of\n HN<\/jats:styled-content>\n 001 against eczema, when given for the first 2\u00a0years of life only, extended to at least 4\u00a0years of age. This, together with our findings for a protective effect against rhinoconjunctivitis, suggests that this probiotic might be an appropriate preventative intervention for high risk infants.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/j.1365-2222.2012.03975.x","type":"journal-article","created":{"date-parts":[[2012,2,6]],"date-time":"2012-02-06T22:41:07Z","timestamp":1328568067000},"page":"1071-1079","source":"Crossref","is-referenced-by-count":158,"title":["A protective effect of\n L<\/scp>\n actobacillus rhamnosus<\/i>\n HN<\/scp>\n 001 against eczema in the first 2\u00a0years of life persists to age 4\u00a0years"],"prefix":"10.1111","volume":"42","author":[{"given":"K.","family":"Wickens","sequence":"first","affiliation":[{"name":"Wellington Asthma Research Group Wellington School of Medicine and Health Sciences University of Otago Wellington New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Black","sequence":"additional","affiliation":[{"name":"Formerly Department of Pharmacology and Clinical Pharmacology University of Auckland Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. V.","family":"Stanley","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Wellington School of Medicine and Health Sciences University of Otago Wellington New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Mitchell","sequence":"additional","affiliation":[{"name":"Department of Paediatrics University of Auckland Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Barthow","sequence":"additional","affiliation":[{"name":"Wellington Asthma Research Group Wellington School of Medicine and Health Sciences University of Otago Wellington New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Fitzharris","sequence":"additional","affiliation":[{"name":"Immunology Department Auckland Hospital Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Purdie","sequence":"additional","affiliation":[{"name":"Dean's Department Wellington School of Medicine and Health Sciences University of Otago Wellington New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Crane","sequence":"additional","affiliation":[{"name":"Wellington Asthma Research Group Wellington School of Medicine and Health Sciences University of Otago Wellington New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,6,15]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.07.011"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.299.6710.1259"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.02.012"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)04259-8"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2006.09.009"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2007.01.007"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2006.08.036"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-1492"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2008.03133.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2009.00958.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2008.03008.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2009.02021.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2009.00745.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2010.09889.x"},{"issue":"4","key":"e_1_2_6_16_1","first-page":"CD006475","article-title":"Probiotics in infants for prevention of allergic disease and food hypersensitivity (Review)","author":"Osborn D","year":"2007","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_6_17_1","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1097\/MOP.0b013e32833d9728","article-title":"Probiotics and prebiotics: clinical effects in allergic disease","volume":"22","author":"Tang M","year":"2010","journal-title":"Curr Opin Pediatr"},{"key":"e_1_2_6_18_1","unstructured":"WilliamsH.So how do I define atopic eczema? A practical manual for researchers wishing to define atopic eczema.1996[cited. Available from:http:\/\/www.nottingham.ac.uk\/dermatology\/eczema\/contents.html(accessed 14 June 2008)."},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1159\/000247298"},{"key":"e_1_2_6_20_1","unstructured":"ASCIA skin prick testing working party.Skin prick testing for the diagnosis of allergic disease. A manual for practitioners.2009. Available fromhttp:\/\/www.allergy.org.au\/images\/stories\/ascia_spt_manual_2009.pdf(accessed 14 June 2008)."},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.95.08030483"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.320.7244.1240"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39238.39944455"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.25975-0"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)13490-3"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2006.12.608"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.11.019"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)60219-0"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2008.01778.x"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2002.120273"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2010.02507.x"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2008.03061.x"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2009.03.007"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.1999.00560.x"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2001.111237"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102180\u20109\u2010123"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2003.01835.x"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.2500\/aap.2010.31.3313"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114500000210"}],"container-title":["Clinical & Experimental Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2222.2012.03975.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2222.2012.03975.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T04:44:02Z","timestamp":1698727442000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2222.2012.03975.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6,15]]},"references-count":38,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2012,7]]}},"alternative-id":["10.1111\/j.1365-2222.2012.03975.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2222.2012.03975.x","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.717954423.793460283","asserted-by":"object"}]},"ISSN":["0954-7894","1365-2222"],"issn-type":[{"value":"0954-7894","type":"print"},{"value":"1365-2222","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,6,15]]}}}