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Current knowledge and novel findings will be reviewed and open research questions identified, to give basic scientists, immunologists and clinicians an overview of an emerging research field.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>PubMed\u2010search on pre\u2010defined terms and cross\u2010references.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Several studies have shown a correlation between low birth weight and\/or gestational age and asthma and high birth weight and\/or gestational age and atopy. The exact mechanism is not yet clear but both environmental and genetic factors seem to contribute to fetal growth. Some of these factors are confounders that can be adjusted for, and twin studies have been very helpful in this context. Suggested mechanisms behind fetal growth are often linked to the feto\u2010maternal circulation, including the development of placenta and umbilical cord. However, the causal link between fetal growth restriction and subsequent asthma and allergic disease remains unexplained. New research regarding the catch\u2010up growth following growth restriction has posited an alternative theory that diseases later on in life result from rapid catch\u2010up growth rather than intrauterine growth restriction<jats:italic>per se<\/jats:italic>. Several studies have found a correlation between a rapid weight gain after birth and development of asthma or wheezing in childhood.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion and clinical relevance<\/jats:title><jats:p>Asthma and allergic disease are multifactorial. Several mechanisms seem to influence their development. Additional studies are needed before we fully understand the causal links between fetal growth and development of asthma and allergic diseases.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1365-2222.2012.03997.x","type":"journal-article","created":{"date-parts":[[2012,3,8]],"date-time":"2012-03-08T23:10:31Z","timestamp":1331248231000},"page":"1430-1447","source":"Crossref","is-referenced-by-count":57,"title":["Fetal growth and risk of childhood asthma and allergic disease"],"prefix":"10.1111","volume":"42","author":[{"given":"S. G.","family":"Tedner","sequence":"first","affiliation":[{"name":"Department of Medical Epidemiology and Biostatistics Karolinska University Hospital and Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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