{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T00:34:55Z","timestamp":1768782895519,"version":"3.49.0"},"reference-count":180,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2012,11,26]],"date-time":"2012-11-26T00:00:00Z","timestamp":1353888000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The airway diseases asthma and chronic obstructive pulmonary disease (<jats:styled-content style=\"fixed-case\">COPD<\/jats:styled-content>) are heterogeneous conditions with overlapping pathophysiological and clinical features. It has previously been proposed that this heterogeneity may be characterized in terms of five relatively independent domains labelled from <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> to <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>, namely airway hyperresponsiveness (<jats:styled-content style=\"fixed-case\">AHR<\/jats:styled-content>), bronchitis, cough reflex hypersensitivity, damage to the airways and surrounding lung parenchyma, and extrapulmonary factors. Airway hyperresponsiveness occurs in both asthma and <jats:styled-content style=\"fixed-case\">COPD<\/jats:styled-content>, accounting for variable day to day symptoms, although the mechanisms most likely differ between the two conditions. Bronchitis, or airway inflammation, may be predominantly eosinophilic or neutrophilic, with different treatments required for each. Cough reflex hypersensitivity is thought to underlie the chronic dry cough out of proportion to other symptoms that can occur in association with airways disease. Structural changes associated with airway disease (damage) include bronchial wall thickening, airway smooth muscle hypertrophy, bronchiectasis and emphysema. Finally, a variety of extrapulmonary factors may impact upon airway disease, including rhinosinusitis, gastroesophageal reflux disease, obesity and dysfunctional breathing. This article discusses the <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> to <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content> concept in detail and describes how this framework may be used to assess and treat patients with airway diseases in the clinic.<\/jats:p>","DOI":"10.1111\/j.1365-2222.2012.04008.x","type":"journal-article","created":{"date-parts":[[2012,4,3]],"date-time":"2012-04-03T16:38:40Z","timestamp":1333471120000},"page":"1664-1683","source":"Crossref","is-referenced-by-count":31,"title":["Phenotyping airways disease: an <scp>A<\/scp> to <scp>E<\/scp> approach"],"prefix":"10.1111","volume":"42","author":[{"given":"S.","family":"Gonem","sequence":"first","affiliation":[{"name":"Department of Infection Immunity &amp; Inflammation Institute for Lung Health University of Leicester Leicester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Raj","sequence":"additional","affiliation":[{"name":"Department of Infection Immunity &amp; Inflammation Institute for Lung Health University of Leicester Leicester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. J.","family":"Wardlaw","sequence":"additional","affiliation":[{"name":"Department of Infection Immunity &amp; Inflammation Institute for Lung Health University of Leicester Leicester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I. D.","family":"Pavord","sequence":"additional","affiliation":[{"name":"Department of Infection Immunity &amp; Inflammation Institute for Lung Health University of Leicester Leicester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Green","sequence":"additional","affiliation":[{"name":"Department of Infection Immunity &amp; Inflammation Institute for Lung Health University of Leicester Leicester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Siddiqui","sequence":"additional","affiliation":[{"name":"Department of Infection Immunity &amp; Inflammation Institute for Lung Health University of Leicester Leicester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,11,26]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.2604008"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1513\/pats.200402-009MS"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.121.4.1051"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.58.8.659"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.01.003"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00170110"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.2147\/copd.2006.1.1.39"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.2604007"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2009.03410.x"},{"key":"e_1_2_11_11_1","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1183\/09031936.06.00056106","article-title":"Asthma, COPD and bronchitis are just components of airway disease","volume":"28","author":"Hargreave FE","year":"2006","journal-title":"Eur Respir J"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.53.5.419"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200211-1268OC"},{"key":"e_1_2_11_14_1","first-page":"589","article-title":"The functional consequences of airway remodeling in asthma","volume":"52","author":"Par\u00e9 PD","year":"1997","journal-title":"Monaldi Arch Chest Dis"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00408-009-9163-5"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1843.2010.01712.x"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.159.4.9806052"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.10-0088"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2007.02878.x"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.10-0231"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.11-1748"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.164.5.2011026"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.2108009"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2005.052241"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1014350"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCP.0b013e32833303d2"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjp.2008.284"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1008770"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pupt.2011.03.006"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200612-1814OC"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00162506"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.05.020"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2007.10.028"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa050580"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200809-1512OC"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00389.2001"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00884.2004"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01180.2002"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00112606"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2237"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.158.supplement_2.13tac170"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02815-4"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.2147\/copd.2006.1.1.49"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-12-11"},{"key":"e_1_2_11_45_1","first-page":"60","article-title":"Airways disease: phenotyping heterogeneity using measures of airway inflammation","volume":"3","author":"Siddiqui S","year":"2007","journal-title":"Allergy Asthma Clin Immunol"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.161.2.9903097"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.162.3.9908057"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1159\/000245899"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0012-3692(15)31427-6"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.10.024"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.57.10.875"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2006.073429"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)11679-5"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1177\/147323000603400202"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.06.00137704"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00146306"},{"key":"e_1_2_11_57_1","first-page":"CD005603","article-title":"Tailored interventions based on sputum eosinophils versus clinical symptoms for asthma in children and adults","author":"Petsky HL","year":"2007","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2005.02314.x"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa043596"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200610-1427OC"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)61448-8"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2010.135574"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200701-085OC"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0808991"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0805435"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200711-1754OC"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.10-1194"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2008.01881.x"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200312-1651OC"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.2478\/v10039-011-0024-0"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.01.005"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2009.03383.x"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V95.10.3146"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.36.179"},{"key":"e_1_2_11_75_1","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.4049\/jimmunol.157.4.1678","article-title":"Activation of human eosinophils by IL\u201013. Induction of CD69 surface antigen, its relationship to messenger RNA expression, and promotion of cellular viability","volume":"157","author":"Luttmann W","year":"1996","journal-title":"J Immunol"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1106469"},{"key":"e_1_2_11_77_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCP.0b013e3283341ba0"},{"key":"e_1_2_11_78_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.160.5.9806170"},{"key":"e_1_2_11_79_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.119.5.1329"},{"key":"e_1_2_11_80_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.120.6.1917"},{"key":"e_1_2_11_81_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.07-1047"},{"key":"e_1_2_11_82_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.08-0049"},{"key":"e_1_2_11_83_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00139810"},{"key":"e_1_2_11_84_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2009.126722"},{"key":"e_1_2_11_85_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2006.061358"},{"key":"e_1_2_11_86_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00042208"},{"key":"e_1_2_11_87_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.157.6.9710075"},{"key":"e_1_2_11_88_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200707-1134OC"},{"key":"e_1_2_11_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2011.02.002"},{"key":"e_1_2_11_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2010.02.018"},{"key":"e_1_2_11_91_1","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-7-135"},{"key":"e_1_2_11_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.02.024"},{"key":"e_1_2_11_93_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.09-3058"},{"key":"e_1_2_11_94_1","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.58.4.339"},{"key":"e_1_2_11_95_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0306-5251.2001.01475.x"},{"key":"e_1_2_11_96_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00057407"},{"key":"e_1_2_11_97_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2006.067413"},{"key":"e_1_2_11_98_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa012705"},{"key":"e_1_2_11_99_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2009.01951.x"},{"key":"e_1_2_11_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2004.08.032"},{"key":"e_1_2_11_101_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2466-9-34"},{"key":"e_1_2_11_102_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2006.062141"},{"key":"e_1_2_11_103_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.7.5001"},{"key":"e_1_2_11_104_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.1995.tb01017.x"},{"key":"e_1_2_11_105_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3003.2000.15d10.x"},{"key":"e_1_2_11_106_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2005.02222.x"},{"key":"e_1_2_11_107_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACI.0b013e328012c587"},{"key":"e_1_2_11_108_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.20114"},{"key":"e_1_2_11_109_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2006.064337"},{"key":"e_1_2_11_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2003.10.005"},{"key":"e_1_2_11_111_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2004.034900"},{"key":"e_1_2_11_112_1","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.58.12.1066"},{"key":"e_1_2_11_113_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh653"},{"key":"e_1_2_11_114_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000125287.98456.23"},{"key":"e_1_2_11_115_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348940511400401"},{"key":"e_1_2_11_116_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000244377.60334.e3"},{"key":"e_1_2_11_117_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.110.000802"},{"key":"e_1_2_11_118_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.09-1960"},{"key":"e_1_2_11_119_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa032158"},{"key":"e_1_2_11_120_1","doi-asserted-by":"publisher","DOI":"10.1513\/pats.200907-079DP"},{"key":"e_1_2_11_121_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3003.1999.14d27.x"},{"key":"e_1_2_11_122_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.04.00077803"},{"key":"e_1_2_11_123_1","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.58.4.322"},{"key":"e_1_2_11_124_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-5994.2006.01214.x"},{"key":"e_1_2_11_125_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.159.4.9807121"},{"key":"e_1_2_11_126_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.127.6.1952"},{"key":"e_1_2_11_127_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61379-8"},{"key":"e_1_2_11_128_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.161.2.9901044"},{"key":"e_1_2_11_129_1","first-page":"CD002991","article-title":"Inhaled corticosteroids for stable chronic obstructive pulmonary disease","author":"Yang IA","year":"2007","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_11_130_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2010.03.033"},{"key":"e_1_2_11_131_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.07-2779"},{"key":"e_1_2_11_132_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2006.07.032"},{"key":"e_1_2_11_133_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.09-0174"},{"key":"e_1_2_11_134_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2010.136374"},{"key":"e_1_2_11_135_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200505-810OC"},{"key":"e_1_2_11_136_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2010.03.048"},{"key":"e_1_2_11_137_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.22388"},{"key":"e_1_2_11_138_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00138508"},{"key":"e_1_2_11_139_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2005.05.026"},{"key":"e_1_2_11_140_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2008.04.015"},{"key":"e_1_2_11_141_1","doi-asserted-by":"publisher","DOI":"10.1159\/000225373"},{"key":"e_1_2_11_142_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.100.3.813"},{"key":"e_1_2_11_143_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200003163421102"},{"key":"e_1_2_11_144_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2003.1388"},{"key":"e_1_2_11_145_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201001-0087OC"},{"key":"e_1_2_11_146_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2010.02542.x"},{"key":"e_1_2_11_147_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa064707"},{"key":"e_1_2_11_148_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200704-571OC"},{"key":"e_1_2_11_149_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200903-0354OC"},{"key":"e_1_2_11_150_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200507-1162OC"},{"key":"e_1_2_11_151_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2006.05.069"},{"key":"e_1_2_11_152_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa11798"},{"key":"e_1_2_11_153_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0900928"},{"key":"e_1_2_11_154_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thorsurg.2009.04.003"},{"key":"e_1_2_11_155_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2466-11-1"},{"key":"e_1_2_11_156_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(02)04553-8"},{"key":"e_1_2_11_157_1","doi-asserted-by":"publisher","DOI":"10.3348\/kjr.2011.12.1.25"},{"key":"e_1_2_11_158_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0806290"},{"key":"e_1_2_11_159_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200910-1537OC"},{"key":"e_1_2_11_160_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200507-1167OC"},{"key":"e_1_2_11_161_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.128.5.3140"},{"key":"e_1_2_11_162_1","doi-asserted-by":"publisher","DOI":"10.1080\/02770900802249149"},{"key":"e_1_2_11_163_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2007.086819"},{"key":"e_1_2_11_164_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.05.016"},{"key":"e_1_2_11_165_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2007.086470"},{"key":"e_1_2_11_166_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2005.042523"},{"key":"e_1_2_11_167_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100084450"},{"key":"e_1_2_11_168_1","doi-asserted-by":"publisher","DOI":"10.2165\/00151829-200504050-00004"},{"key":"e_1_2_11_169_1","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.2006.052522"},{"key":"e_1_2_11_170_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.322.7294.1098"},{"key":"e_1_2_11_171_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcrj.2004.10.007"},{"key":"e_1_2_11_172_1","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.58.2.110"},{"key":"e_1_2_11_173_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2008.100867"},{"key":"e_1_2_11_174_1","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.57.12.1034"},{"key":"e_1_2_11_175_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2004.025593"},{"key":"e_1_2_11_176_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcrj.2005.08.004"},{"key":"e_1_2_11_177_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200902-0166OC"},{"key":"e_1_2_11_178_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201003-0472OC"},{"key":"e_1_2_11_179_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.03.00405703"},{"key":"e_1_2_11_180_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200508-1211ST"},{"key":"e_1_2_11_181_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200710-1508OC"}],"container-title":["Clinical &amp; Experimental Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2222.2012.04008.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2222.2012.04008.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T00:06:17Z","timestamp":1697414777000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2222.2012.04008.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11,26]]},"references-count":180,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["10.1111\/j.1365-2222.2012.04008.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2222.2012.04008.x","archive":["Portico"],"relation":{},"ISSN":["0954-7894","1365-2222"],"issn-type":[{"value":"0954-7894","type":"print"},{"value":"1365-2222","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,11,26]]}}}