{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T01:12:49Z","timestamp":1789866769023,"version":"4.0.1"},"reference-count":32,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2012,8,28]],"date-time":"2012-08-28T00:00:00Z","timestamp":1346112000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Fractional exhaled Nitric Oxide (<jats:styled-content style=\"fixed-case\">FeNO<\/jats:styled-content>) is a surrogate biomarker of the degree of eosinophilic airway inflammation. Using longitudinal latent class analysis, five wheezing phenotypes have been identified, characterized by different ages of onset and prognosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To assess <jats:styled-content style=\"fixed-case\">FeNO<\/jats:styled-content> measured at 4 and 8\u00a0years in children with different phenotypes of wheeze and atopy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Children participated in the Prevention and Incidence of Asthma and Mite Allergy (<jats:styled-content style=\"fixed-case\">PIAMA<\/jats:styled-content>) study, a prospective birth cohort in the Netherlands. Respiratory health was assessed yearly by questionnaires until the age of 8\u00a0years; these data were used to identify five wheezing phenotypes. Associations between <jats:styled-content style=\"fixed-case\">FeNO<\/jats:styled-content> and wheezing phenotypes were investigated using weighted linear regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Data on wheezing phenotypes and <jats:styled-content style=\"fixed-case\">FeNO<\/jats:styled-content> at 4 and 8\u00a0years were available in 588 and 973 children respectively. Compared with the phenotype of never and transient wheeze, <jats:styled-content style=\"fixed-case\">FeNO<\/jats:styled-content> at 4\u00a0years was higher in intermediate onset and persistent wheeze. <jats:styled-content style=\"fixed-case\">FeNO<\/jats:styled-content> at 8\u00a0years of age differed significantly between all phenotypes, with highest <jats:styled-content style=\"fixed-case\">FeNO<\/jats:styled-content> values for persistent, intermediate onset, and late onset wheeze. Rise in <jats:styled-content style=\"fixed-case\">FeNO<\/jats:styled-content> from 4 to 8\u00a0years in intermediate and late onset wheezers was significantly higher compared to FeNO rise in never and transient wheezers. Stratified analyses showed that the increase in <jats:styled-content style=\"fixed-case\">FeNO<\/jats:styled-content> in persistent, intermediate, and late onset wheeze was only present in children with allergic sensitization at 8\u00a0years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Clinical Relevance<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">FeNO<\/jats:styled-content> measured at 8\u00a0years was associated with specific wheezing phenotypes, only among atopic children.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1365-2222.2012.04010.x","type":"journal-article","created":{"date-parts":[[2012,4,3]],"date-time":"2012-04-03T19:07:40Z","timestamp":1333480060000},"page":"1329-1336","source":"Crossref","is-referenced-by-count":39,"title":["Childhood wheezing phenotypes and <scp><scp>FeNO<\/scp><\/scp> in atopic children at age\u00a08"],"prefix":"10.1111","volume":"42","author":[{"given":"R. J. P.","family":"van der Valk","sequence":"first","affiliation":[{"name":"Department of Pediatrics Erasmus University Medical Center, Sophia Children's Hospital  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Caudri","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Erasmus University Medical Center, Sophia Children's Hospital  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Savenije","sequence":"additional","affiliation":[{"name":"Department of Epidemiology UMCG, GRIAC Research Institute, University of Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. H.","family":"Koppelman","sequence":"additional","affiliation":[{"name":"Department of Pediatric Pulmonology and Pediatric Allergology Beatrix Children's Hospital, UMCG, GRIAC Research Institute, University of Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. A.","family":"Smit","sequence":"additional","affiliation":[{"name":"Julius Center for Health Sciences and Primary Care University Medical Center Utrecht  Utrecht The Netherlands"},{"name":"Centre for Prevention and Health Services Research National Institute for Public Health and the Environment (RIVM)  Bilthoven The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. H.","family":"Wijga","sequence":"additional","affiliation":[{"name":"Centre for Prevention and Health Services Research National Institute for Public Health and the Environment (RIVM)  Bilthoven The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. S.","family":"Postma","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine UMCG, GRIAC Research Institute, University of Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Kerkhof","sequence":"additional","affiliation":[{"name":"Department of Epidemiology UMCG, GRIAC Research Institute, University of Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Brunekreef","sequence":"additional","affiliation":[{"name":"Julius Center for Health Sciences and Primary Care University Medical Center Utrecht  Utrecht The Netherlands"},{"name":"Division of Environmental Epidemiology Institute for Risk Assessment Sciences, Utrecht University  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. C.","family":"de Jongste","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Erasmus University Medical Center, Sophia Children's Hospital  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,8,28]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200406-710ST"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2007.02897.x"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-10-28"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/jes.2008.64"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3003.1999.14d28.x"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2009.125443"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.58.6.494"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00079604"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199501193320301"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1843.2005.00628.x"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.2003.01800.x"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2000.105318"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2007.093187"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.02.002"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.95.08030483"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3038.13.s.15.1.x"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.01.17508980"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.02.00293102"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.56.4.285"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.1124"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200310-1376OC"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1081\/JAS-200057908"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.58.12.1048"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2005.03.039"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)69257-X"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2008.143636"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.159.5.9805028"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2007.11.008"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2005.03.020"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prrv.2007.12.004"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/25.3.609"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200909-1377OC"}],"container-title":["Clinical &amp; Experimental Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2222.2012.04010.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2222.2012.04010.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T00:04:13Z","timestamp":1698710653000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2222.2012.04010.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8,28]]},"references-count":32,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2012,9]]}},"alternative-id":["10.1111\/j.1365-2222.2012.04010.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2222.2012.04010.x","archive":["Portico"],"relation":{},"ISSN":["0954-7894","1365-2222"],"issn-type":[{"value":"0954-7894","type":"print"},{"value":"1365-2222","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,8,28]]}}}