{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T05:31:01Z","timestamp":1791091861094,"version":"4.1.0"},"reference-count":53,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2012,8,28]],"date-time":"2012-08-28T00:00:00Z","timestamp":1346112000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2012,9]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Hematopoietic progenitor cells, especially those committed to the E<\/jats:styled-content>o\/B<\/jats:styled-content> lineage, are known to contribute to allergic inflammation.<\/jats:p><\/jats:sec>Objective<\/jats:title>The aim of the present study was to investigate whether environmental factors are associated with changes in numbers of circulating E<\/jats:styled-content>o\/B<\/jats:styled-content> progenitors at 1\u00a0year of age.<\/jats:p><\/jats:sec>Methods<\/jats:title>Peripheral blood from 60 1\u2010year\u2010old children enrolled in the LINA<\/jats:styled-content> (Lifestyle and environmental factors and their Influence on Newborns Allergy risk) birth cohort was assessed for E<\/jats:styled-content>o\/B<\/jats:styled-content> progenitor cells (E<\/jats:styled-content>o\/B CFU<\/jats:styled-content>) using standardized and validated methylcellulose assays. Frozen peripheral blood mononuclear cells (PBMC<\/jats:styled-content>) were cultured in the presence of IL<\/jats:styled-content>\u20103, IL<\/jats:styled-content>\u20105 or GM<\/jats:styled-content>\u2010CSF<\/jats:styled-content>, and E<\/jats:styled-content>o\/B CFU<\/jats:styled-content>s enumerated. Clinical outcomes and exposure to environmental tobacco smoke (ETS<\/jats:styled-content>) were documented by standardized questionnaires, and indoor volatile organic compound (VOC<\/jats:styled-content>) concentrations were assessed by passive sampling.<\/jats:p><\/jats:sec>Results<\/jats:title>Children with skin manifestations (atopic dermatitis or cradle cap) within the first year of life had higher numbers of circulating IL<\/jats:styled-content>\u20103\u2010, IL<\/jats:styled-content>\u20105\u2010 or GM<\/jats:styled-content>\u2010CSF<\/jats:styled-content>\u2010stimulated E<\/jats:styled-content>o\/B CFU<\/jats:styled-content>s (P<\/jats:italic>\u00a0<\u00a00.05) at 1\u00a0year. In children with cradle cap, a positive correlation was found between E<\/jats:styled-content>o\/B CFU<\/jats:styled-content>s and exposure to ETS<\/jats:styled-content>\u2010related VOC<\/jats:styled-content>s during pregnancy or at 1\u00a0year of age (P<\/jats:italic>\u00a0<\u00a00.05).<\/jats:p><\/jats:sec>Conclusions and Clinical Relevance<\/jats:title>This is the first demonstration that environmental exposures are positively associated with levels of circulating E<\/jats:styled-content>o\/B<\/jats:styled-content> progenitors. The recruitment and differentiation of E<\/jats:styled-content>o\/B<\/jats:styled-content> progenitors in response to environmental triggers may play a role in the development of skin manifestations during the first year of life.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1365-2222.2012.04024.x","type":"journal-article","created":{"date-parts":[[2012,4,30]],"date-time":"2012-04-30T08:25:37Z","timestamp":1335774337000},"page":"1337-1346","source":"Crossref","is-referenced-by-count":32,"title":["The LINA<\/scp> cohort: indoor chemical exposure, circulating eosinophil\/basophil (E<\/scp>o\/B<\/scp>) progenitors and early life skin manifestations"],"prefix":"10.1111","volume":"42","author":[{"given":"K.","family":"Weisse","sequence":"first","affiliation":[{"name":"Helmholtz Centre for Environmental Research \u2013 UFZ Department of Environmental Immunology Leipzig Germany"},{"name":"Division of Clinical Immunology and Allergy Department of Medicine McMaster University Hamilton ON 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