{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T08:41:07Z","timestamp":1761986467439},"reference-count":50,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2012,8,28]],"date-time":"2012-08-28T00:00:00Z","timestamp":1346112000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The literature is contradictory concerning pet exposure and risk of allergic disease in childhood especially among those with a family history of allergy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the relationship between cat and dog exposure at birth and allergic outcomes over the first 12\u00a0years in a birth cohort selected for familial allergy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A prospective birth cohort of 620 infants with a family history of allergic diseases was recruited. Data on pet keeping, family demographics and cord blood samples were collected at birth. Information on childhood wheeze, eczema and hay fever was collected 18 times in the first 2\u00a0years, at 7\u00a0years and at 12\u00a0years. Skin prick tests were conducted at 2, 7 and 12\u00a0years, and in parents. Regression analyses were used to investigate the relevant associations while adjusting for potential confounders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Exposure to cats or dogs at birth showed a moderate reduction in risk of wheeze (<jats:styled-content style=\"fixed-case\">aOR<\/jats:styled-content>\u00a0=\u00a00.76; 95% CI 0.53, 1.09) and hay fever (<jats:styled-content style=\"fixed-case\">aOR<\/jats:styled-content>\u00a0=\u00a00.71; 0.49, 1.02) after 7\u00a0years of age. Protective effects were stronger in children of non\u2010sensitized fathers (<jats:styled-content style=\"fixed-case\">aOR<\/jats:styled-content> wheeze 0.55; 0.31, 0.98; <jats:styled-content style=\"fixed-case\">aOR<\/jats:styled-content> hay fever 0.33; 0.15, 0.77 on exposure to cats alone, or cats or dogs at birth). Pet keeping was not related to cord blood IgE or sensitization from 2 to 12  years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Clinical Relevance<\/jats:title><jats:p>Pets at birth either decreased or had no effect on allergic disease up to age 12. We found no evidence that exposure to cats or dogs at birth increases the risk of allergic disease in high\u2010risk children.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1365-2222.2012.04032.x","type":"journal-article","created":{"date-parts":[[2012,5,14]],"date-time":"2012-05-14T18:50:11Z","timestamp":1337021411000},"page":"1377-1385","source":"Crossref","is-referenced-by-count":38,"title":["Pets at birth do not increase allergic disease in at\u2010risk children"],"prefix":"10.1111","volume":"42","author":[{"given":"C. J.","family":"Lodge","sequence":"first","affiliation":[{"name":"Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, School of Population Health University of Melbourne Melbourne Vic. Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. J.","family":"Lowe","sequence":"additional","affiliation":[{"name":"Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, School of Population Health University of Melbourne Melbourne Vic. Australia"},{"name":"Murdoch Children's Research Institute Royal Children's Hospital Parkville Melbourne Vic. Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. C.","family":"Gurrin","sequence":"additional","affiliation":[{"name":"Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, School of Population Health University of Melbourne Melbourne Vic. Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. C.","family":"Matheson","sequence":"additional","affiliation":[{"name":"Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, School of Population Health University of Melbourne Melbourne Vic. Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Balloch","sequence":"additional","affiliation":[{"name":"Murdoch Children's Research Institute Royal Children's Hospital Parkville Melbourne Vic. Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Axelrad","sequence":"additional","affiliation":[{"name":"Murdoch Children's Research Institute Royal Children's Hospital Parkville Melbourne Vic. Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. J.","family":"Hill","sequence":"additional","affiliation":[{"name":"Murdoch Children's Research Institute Royal Children's Hospital Parkville Melbourne Vic. Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. S.","family":"Hosking","sequence":"additional","affiliation":[{"name":"Department of Paediatrics John Hunter Children's Hospital New Lambton NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, School of Population Health University of Melbourne Melbourne Vic. Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Svanes","sequence":"additional","affiliation":[{"name":"Bergen Respiratory Research Group, Institute of Medicine University of Bergen Bergen Norway"},{"name":"Dept Occupational Medicine Haukeland University Hospital Bergen Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. J.","family":"Abramson","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Preventive Medicine Monash University, The Alfred Hospital Melbourne Vic. Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. J.","family":"Allen","sequence":"additional","affiliation":[{"name":"Murdoch Children's Research Institute Royal Children's Hospital Parkville Melbourne Vic. Australia"},{"name":"Royal Children's Hospital Parkville Vic. Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. C.","family":"Dharmage","sequence":"additional","affiliation":[{"name":"Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, School of Population Health University of Melbourne Melbourne Vic. 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