{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T17:08:52Z","timestamp":1789578532494,"version":"build-2803163510"},"reference-count":23,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2012,11,26]],"date-time":"2012-11-26T00:00:00Z","timestamp":1353888000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Previous studies have suggested an association between allergy and mood and anxiety disorders. Yet, extant work suffers from methodological limitations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the association between physician\u2010diagnosed allergy and <jats:styled-content style=\"fixed-case\">DSM<\/jats:styled-content>\u2010IV mood and anxiety disorders in the general population, and to examine the role of allergy treatment in this relationship.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data were drawn from the <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>erman <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>ational <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>ealth <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>nterview and <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>xamination <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>urvey, a population\u2010based, representative sample of 4,181 adults aged 18\u201065 in <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>ermany. Allergy was diagnosed by physicians during medical examination and mental disorders were diagnosed using the <jats:styled-content style=\"fixed-case\">CIDI<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Allergy was associated with an increased prevalence of any anxiety disorder [<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a01.3 (1.1, 1.6)], panic attacks [<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a01.6 (1.1, 2.1)], panic disorder [<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a01.6 (1.01, 2.3)], <jats:styled-content style=\"fixed-case\">GAD<\/jats:styled-content> [<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a01.8 (1.1, 3.0)], any mood disorder [<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a01.4 (1.1, 1.7)], depression [<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a01.4 (1.1, 1.7)] and bipolar disorder [<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a02.0, (1.0, 3.8)]. After adjusting for desensitization treatment status, these relationships were no longer significant. Those treated for allergy were significantly less likely to have any mood or anxiety disorder [<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a00.65 (0.4, 0.96)], compared to those untreated. All relationships were adjusted for age, gender and socioeconomic status (<jats:styled-content style=\"fixed-case\">SES<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions &amp; Clinical Relevance<\/jats:title><jats:p>These findings provide the first evidence of a link between physician\u2010diagnosed allergy and <jats:styled-content style=\"fixed-case\">DSM<\/jats:styled-content>\u2010IV mood and anxiety disorders in a representative sample. Treatment for allergy may mitigate much of this relationship.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1365-2222.2012.04042.x","type":"journal-article","created":{"date-parts":[[2012,5,22]],"date-time":"2012-05-22T08:14:58Z","timestamp":1337674498000},"page":"1765-1771","source":"Crossref","is-referenced-by-count":30,"title":["Impact of allergy treatment on the association between allergies and mood and anxiety in a population sample"],"prefix":"10.1111","volume":"42","author":[{"given":"R. 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