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Often only one of the methods is used to determine sensitization; however, it is still under debate whether these two methods can be used interchangeably.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To investigate the concordance of SPT and <jats:styled-content style=\"fixed-case\">sIgE<\/jats:styled-content> serum assays with regard to suspected food allergy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In 395 children referred to our clinic with suspected cow's milk allergy and in 268 children with suspected hen's egg allergy specific immunoglobulin E (IgE) was measured, a SPT and an oral food challenge performed. A weal size\u00a0\u2265\u00a03\u00a0mm and <jats:styled-content style=\"fixed-case\">sIgE<\/jats:styled-content>\u00a0\u2265\u00a00.35 <jats:styled-content style=\"fixed-case\">kU<\/jats:styled-content>\/L were considered positive. The weal size of the SPT and the level of food\u2010specific IgE were tested for correlation for each allergen.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 395 (23%) children orally challenged with cow's milk, 92 showed no corresponding results for SPT and <jats:styled-content style=\"fixed-case\">sIgE<\/jats:styled-content> as either positive or negative. For hen's egg, in 27 of 268 (10%) children differing test results for SPT and <jats:styled-content style=\"fixed-case\">sIgE<\/jats:styled-content> in serum were obtained. Moreover, regarding the quantitative values for <jats:styled-content style=\"fixed-case\">sIgE<\/jats:styled-content> and SPT in children with or without clinically relevant food allergy, <jats:styled-content style=\"fixed-case\">sIgE<\/jats:styled-content> and SPT correlated badly.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The concordance between SPT and <jats:styled-content style=\"fixed-case\">sIgE<\/jats:styled-content> is surprisingly low for cow's milk and hen's egg on an individual basis. Therefore, the tests should not be used interchangeably. Especially in children who receive a negative test result the alternative test should also be used. Furthermore, our data indicate again that oral food challenges are still the method of choice to diagnose food allergies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1365-2222.2012.04046.x","type":"journal-article","created":{"date-parts":[[2012,5,28]],"date-time":"2012-05-28T04:39:09Z","timestamp":1338179949000},"page":"1266-1272","source":"Crossref","is-referenced-by-count":46,"title":["Skin prick test and specific serum IgE in the diagnostic evaluation of suspected cow's milk and hen's egg allergy in children: does one replace the other?"],"prefix":"10.1111","volume":"42","author":[{"given":"A.","family":"Mehl","sequence":"first","affiliation":[{"name":"Department of Pediatric Pneumology and Immunology Charit\u00e9 University Medical Center Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Niggemann","sequence":"additional","affiliation":[{"name":"Department of Pediatric Pneumology and Immunology Charit\u00e9 University Medical Center Berlin 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