{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T17:52:27Z","timestamp":1775065947648,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2012,10,29]],"date-time":"2012-10-29T00:00:00Z","timestamp":1351468800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aims<\/jats:title><jats:p>Trigeminal neuralgia is one of the chronic neuropathic pains. The aetiology remains unclear. Chronic inflammation is proposed playing a role in the pathogenesis of trigeminal neuralgia. This study aims to assess the role of allergic inflammation in the pathological status of trigeminal neuralgia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Allergic inflammation was induced in the infraorbital skin of rats. The expression of 5\u2010<jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content> receptor 3 (R3) in the trigeminal nerve and mastocytosis in the local tissue were observed by immunohistochemistry. The hyperalgesia status of the trigeminal nerve was determined by quantitatively recording the head\u2010withdrawal threshold to mechanical stimulation of the infraorbital nerve territory.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After sensitization, the expression of 5\u2010<jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content> R3 in the trigeminal nerve and the frequency of mast cells were markedly increased in the epidermal tissue of the infraorbital area. Applying exogenous 5\u2010<jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content> to the local tissue also increased the expression of 5\u2010<jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content> R3 in the trigeminal nerve. The threshold of mechanical allodynia to stimuli was significantly lower in sensitized rats than control rats, which could be blocked by pre\u2010treatment with either 5\u2010<jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content> R3 antagonists, or neurokinin\u20101 antagonists, or mast cell stabilizers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Allergic inflammation can induce the overexpression of 5\u2010<jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content> R3 in the trigeminal nerve to induce the hyperalgesia status in the trigeminal nerve. The 5\u2010<jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content> R3 may be a therapeutic target in the treatment of trigeminal neuralgia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1365-2222.2012.04051.x","type":"journal-article","created":{"date-parts":[[2012,6,17]],"date-time":"2012-06-17T21:22:14Z","timestamp":1339968134000},"page":"1638-1642","source":"Crossref","is-referenced-by-count":4,"title":["Sensitization induces hypersensitivity in trigeminal nerve"],"prefix":"10.1111","volume":"42","author":[{"given":"X.","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Neurosurgery Institute of Surgery Research, Daping Hospital, Third Military Medical University Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Institute of Surgery Research, Daping Hospital, Third Military Medical University Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Institute of Surgery Research, Daping Hospital, Third Military Medical University Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Institute of Surgery Research, Daping Hospital, Third Military Medical University Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Institute of Surgery Research, Daping Hospital, Third Military Medical University Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,10,29]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.2009.080473"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2008.03.002"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2006.01.030"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410270114"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.disamonth.2011.09.003"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pa.20.040180.002301"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpain.2008.07.008"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/1744-8069-7-5"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjoms.2010.03.007"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-61779-536-7_28"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2006.06.014"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2009.01335.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2006.10.028"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.2302\/kjm.60.82"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2011.01843.x"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2011.01862.x"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1017507613236"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.21689"},{"key":"e_1_2_6_20_1","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1213\/ANE.0b013e3182245add","article-title":"A new animal model of trigeminal neuralgia produced by administration of cobra venom to the infraorbital nerve in the rat","volume":"113","author":"An JX","year":"2011","journal-title":"Anesth Analg"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2012.14"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2005.084285"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2011.06.004"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2005.12.004"}],"container-title":["Clinical &amp; 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