{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T23:24:00Z","timestamp":1788305040441,"version":"build-2803163510"},"reference-count":44,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2012,10,29]],"date-time":"2012-10-29T00:00:00Z","timestamp":1351468800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>There is conflicting evidence regarding the associations between anthropometric birth measures and asthma and lung function in children, particularly for apparently healthy infants born at term.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>Our objective was to elucidate these relationships paying particular attention to features of study design and analysis that may threaten the validity of previous studies in this field.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We analysed data from a cohort of children with a family history of asthma who were recruited antenatally. Anthropometric birth measures and potential confounders were recorded at birth and within the first year of life. Lung function and asthma outcomes were measured at 8\u00a0years of age. Airway hyperresponsiveness (<jats:styled-content style=\"fixed-case\">AHR<\/jats:styled-content>) was measured by methacholine challenge. The potential for a reversal paradox, due to inclusion of covariates on the causal pathway, was investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Four hundred and fifty (73% of the initial cohort) children were tested at age 8\u00a0years. Birth weight in the lowest tertile was associated with current asthma (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 1.95, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.08, 3.54) and recent wheeze (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 1.87, 95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.08, 3.24), but not with <jats:styled-content style=\"fixed-case\">AHR<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 1.37, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.68, 2.78). Birth weight was positively associated with lung function. Current height modified the relationship between birth length and lung function suggesting that post\u2010natal growth has an effect on this relationship.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Low birth weight is associated with a greater risk of current asthma and lower lung function at 8\u00a0years in children with a family history of asthma. Current height should be treated as an effect modifier when investigating the fetal origins hypothesis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1365-2222.2012.04056.x","type":"journal-article","created":{"date-parts":[[2012,6,22]],"date-time":"2012-06-22T16:13:42Z","timestamp":1340381622000},"page":"1621-1629","source":"Crossref","is-referenced-by-count":20,"title":["Perinatal factors and respiratory health in children"],"prefix":"10.1111","volume":"42","author":[{"given":"B. 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B.","family":"Marks","sequence":"additional","affiliation":[{"name":"Woolcock Institute of Medical Research The University of Sydney Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the CAPS (Childhood Asthma Prevention Study) Investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,10,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-3782(95)01637-I"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.303.6804.671"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2005.042408"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2006.066241"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2006.112201"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2008.103978"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.02.00234102"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.64.9.1284"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.73.3.231"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.306.6881.817"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.97.10112502"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.319.7204.245"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwi002"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2466-10-14"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2009-0305"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1754.2009.01588.x"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2005.080390"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.158.1.60"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2005.09.042"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2007.00707.x"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2005.2155.x"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2004.01890.x"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.54.10.905"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.2003.01670.x"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwn105"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2006.02518.x"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00055305"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3016.2011.01233.x"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2006.04.004"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.04.031"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-2456(01)00112-X"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00034805"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.38.10.760"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2009.117101"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201012-2075OC"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2007.00449.x"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/31.6.1240"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.75.5.392"},{"key":"e_1_2_7_40_1","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1183\/09031936.93.06050662","article-title":"Predictive nature of bronchial responsiveness and respiratory symptoms in a one year cohort study of Sydney schoolchildren","volume":"6","author":"Peat JK","year":"1993","journal-title":"Eur Respir J"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.3109\/02770909709075661"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.03.00046903"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200610-1441OC"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1993.75.5.2045"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2004.01.003"}],"container-title":["Clinical &amp; 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