{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T22:39:50Z","timestamp":1789684790460,"version":"4.0.1"},"reference-count":57,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2012,10,29]],"date-time":"2012-10-29T00:00:00Z","timestamp":1351468800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2012,11]]},"abstract":"Summary<\/jats:title>\n \n Background<\/jats:title>\n Parasitic helminths have been shown to reduce inflammation in most experimental models of allergic disease, and this effect is mediated via cytokine responses. However, in humans, the effects of controlled helminth infection on cytokine responses during allergy have not been studied.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n \n The aim was to investigate whether infection with the nematode parasite\n \n T<\/jats:styled-content>\n richuris suis\n <\/jats:italic>\n alters systemic cytokine levels, cellular cytokine responses to parasite antigens and pollen allergens and\/or the cytokine profile of allergic individuals.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n In a randomized double\u2010blinded placebo\u2010controlled clinical trial (\n UMIN<\/jats:styled-content>\n trial registry, Registration no. R000001298, Trial\n ID UMIN<\/jats:styled-content>\n 000001070,\n URL<\/jats:styled-content>\n :\n http:\/\/www.umin.ac.jp\/map\/english<\/jats:ext-link>\n ), adults with grass pollen\u2010induced allergic rhinitis received three weekly doses of 2500\n \n T<\/jats:styled-content>\n richuris suis\n <\/jats:italic>\n ova (\n n\u00a0<\/jats:italic>\n =\n \u00a0<\/jats:italic>\n 45) or placebo (\n n\u00a0<\/jats:italic>\n =\n \u00a0<\/jats:italic>\n 44) over 6\u00a0months.\n IFN<\/jats:styled-content>\n \u2010\u03b3,\n TNF<\/jats:styled-content>\n \u2010\u03b1,\n IL<\/jats:styled-content>\n \u20104,\n IL<\/jats:styled-content>\n \u20105,\n IL<\/jats:styled-content>\n \u201010 and\n IL<\/jats:styled-content>\n \u201013 were quantified via cytometric bead array in plasma. Cytokines, including active\n TGF<\/jats:styled-content>\n \u2010\u03b2, were also quantified in supernatants from peripheral blood mononuclear cells cultured with parasite antigens or pollen allergens before, during and after the grass pollen season for a sub\u2010cohort of randomized participants (\n \n T<\/jats:styled-content>\n . suis\n <\/jats:italic>\n ova\u2010treated,\n n\u00a0<\/jats:italic>\n =\n \u00a0<\/jats:italic>\n 12, Placebo\u2010treated,\n n\u00a0<\/jats:italic>\n =\n \u00a0<\/jats:italic>\n 10).\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Helminth infection induced a Th2\u2010polarized cytokine response comprising elevated plasma\n IL<\/jats:styled-content>\n \u20105 and parasite\u2010specific\n IL<\/jats:styled-content>\n \u20104,\n IL<\/jats:styled-content>\n \u20105 and\n IL<\/jats:styled-content>\n \u201013, and a global shift in the profile of systemic cytokine responses. Infection also elicited high levels of the regulatory cytokine\n IL<\/jats:styled-content>\n \u201010 in response to\n \n T<\/jats:styled-content>\n . suis\n <\/jats:italic>\n antigens. Despite increased production of\n \n T<\/jats:styled-content>\n . suis\n <\/jats:italic>\n \u2010specific cytokines in\n \n T<\/jats:styled-content>\n . suis\n <\/jats:italic>\n ova\u2010treated participants, allergen\u2010specific cytokine responses during the grass pollen season and the global profile of\n PBMC<\/jats:styled-content>\n cytokine responses were not affected by\n \n T<\/jats:styled-content>\n . suis\n <\/jats:italic>\n ova treatment.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions and Clinical Relevance<\/jats:title>\n \n This study suggests that cytokines induced by\n \n T<\/jats:styled-content>\n richuris suis\n <\/jats:italic>\n ova treatment do not alter allergic reactivity to pollen during the peak of allergic rhinitis symptoms.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/j.1365-2222.2012.04063.x","type":"journal-article","created":{"date-parts":[[2012,7,9]],"date-time":"2012-07-09T11:37:07Z","timestamp":1341833827000},"page":"1582-1595","source":"Crossref","is-referenced-by-count":26,"title":["\n T<\/scp>\n richuris suis\n <\/i>\n ova therapy for allergic rhinitis does not affect allergen\u2010specific cytokine responses despite a parasite\u2010specific cytokine response"],"prefix":"10.1111","volume":"42","author":[{"given":"C. D.","family":"Bourke","sequence":"first","affiliation":[{"name":"Institute of Immunology and Infection Research School of Biological Sciences University of Edinburgh Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Mutapi","sequence":"additional","affiliation":[{"name":"Institute of Immunology and Infection Research School of Biological Sciences University of Edinburgh Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Nausch","sequence":"additional","affiliation":[{"name":"Institute of Immunology and Infection Research School of Biological Sciences University of Edinburgh Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. M. F.","family":"Photiou","sequence":"additional","affiliation":[{"name":"Institute of Immunology and Infection Research School of Biological Sciences University of Edinburgh Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. K.","family":"Poulsen","sequence":"additional","affiliation":[{"name":"Allergy Clinic National University Hospital Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Kristensen","sequence":"additional","affiliation":[{"name":"Phadia ApS, Aller\u00f8d Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Arnved","sequence":"additional","affiliation":[{"name":"Pulmonology and Allergy Clinic of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"R\u00f8nborg","sequence":"additional","affiliation":[{"name":"Pulmonology and Allergy Clinic of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Roepstorff","sequence":"additional","affiliation":[{"name":"Department of Veterinary Disease Biology Faculty of Life Sciences University of Copenhagen Copenhagen 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