{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T11:22:48Z","timestamp":1790940168888,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2012,9,21]],"date-time":"2012-09-21T00:00:00Z","timestamp":1348185600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Multiple plant\u2010food sensitizations with a complex pattern of clinical manifestations are a common feature of lipid transfer protein (<jats:styled-content style=\"fixed-case\">LTP<\/jats:styled-content>)\u2010allergic patients. Component\u2010resolved diagnosis permits the diagnosis of the allergen sensitization profile.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>We sought to clinically characterize and describe the plant\u2010food and pollen molecular sensitization profile in patients with <jats:styled-content style=\"fixed-case\">LTP<\/jats:styled-content> syndrome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty\u2010five subjects were recruited, after being diagnosed with multiple plant\u2010food allergies sensitized to <jats:styled-content style=\"fixed-case\">LTP<\/jats:styled-content>, but not to any other plant\u2010food allergen, according to the molecular allergen panel tested (Pru p 3 (<jats:styled-content style=\"fixed-case\">LTP<\/jats:styled-content>), Pru p 1 (Bet v 1\u2010like), Pru p 4 (profilin) and those included in a commercial microarray of 103 allergenic components). IgE\u2010mediated food\u2010allergy symptoms and pollinosis were collected. Patients were skin prick tested with a plant\u2010food and pollens panel, and specific IgE to Tri a 14 was evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A heterogeneous group of plant\u2010foods was involved in local and systemic symptoms: oral allergy syndrome (75.6%), urticaria (66.7%), gastrointestinal disorders (55.6%) and anaphylaxis (75.6%), 32.4% of which were cofactor dependent (<jats:italic>Non\u2010Steroidal Anti\u2010inflammatory Drugs<\/jats:italic>, exercise). All tested subjects were positive to peach and Pru p 3, Tri a 14 and to some of the <jats:styled-content style=\"fixed-case\">LTP<\/jats:styled-content>s included in the microarray. Pollinosis was diagnosed in 75.6% of subjects, with a broad spectrum of pollen and pollen\u2010allergen sensitization. Plane tree and mugwort were the statistically significant pollens associated with Pru p 3.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Clinical Relevance<\/jats:title><jats:p>Several plant\u2010foods, taxonomically unrelated, independent of peach involvement, are implicated in <jats:styled-content style=\"fixed-case\">LTP<\/jats:styled-content> syndrome. Local symptoms should be evaluated as a risk marker for anaphylaxis because they are frequently associated with cofactor\u2010dependent anaphylaxis. The association of these symptoms with pollinosis, especially plane tree pollinosis, could be part of this syndrome in our area.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1365-2222.2012.04071.x","type":"journal-article","created":{"date-parts":[[2012,7,13]],"date-time":"2012-07-13T21:01:40Z","timestamp":1342213300000},"page":"1529-1539","source":"Crossref","is-referenced-by-count":160,"title":["Lipid transfer protein syndrome: clinical pattern, cofactor effect and profile of molecular sensitization to plant\u2010foods and pollens"],"prefix":"10.1111","volume":"42","author":[{"given":"M.","family":"Pascal","sequence":"first","affiliation":[{"name":"Servei d'Immunologia, Centre de Diagn\u00f2stic Biom\u00e8dic (CDB) Hospital Cl\u00ednic Barcelona Spain"},{"name":"Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Mu\u00f1oz\u2010Cano","sequence":"additional","affiliation":[{"name":"Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) Barcelona Spain"},{"name":"Unitat d'Al\u00b7l\u00e8rgia, Servei de Pneumologia, Hospital Cl\u00ednic Universitat de Barcelona Barcelona Spain"},{"name":"Centro de Investigaciones en Red de Enfermedades Respiratorias (CIBERES) Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.","family":"Reina","sequence":"additional","affiliation":[{"name":"Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Palac\u00edn","sequence":"additional","affiliation":[{"name":"Centro de Biotecnolog\u00eda y Gen\u00f3mica de Plantas (UPM\u2010INIA) Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Vilella","sequence":"additional","affiliation":[{"name":"Servei d'Immunologia, Centre de Diagn\u00f2stic Biom\u00e8dic (CDB) Hospital Cl\u00ednic Barcelona Spain"},{"name":"Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Picado","sequence":"additional","affiliation":[{"name":"Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) Barcelona Spain"},{"name":"Unitat d'Al\u00b7l\u00e8rgia, Servei de Pneumologia, Hospital Cl\u00ednic Universitat de Barcelona Barcelona Spain"},{"name":"Centro de Investigaciones en Red de Enfermedades Respiratorias (CIBERES) Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Juan","sequence":"additional","affiliation":[{"name":"Servei d'Immunologia, Centre de Diagn\u00f2stic Biom\u00e8dic (CDB) Hospital Cl\u00ednic Barcelona Spain"},{"name":"Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"S\u00e1nchez\u2010L\u00f3pez","sequence":"additional","affiliation":[{"name":"Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) Barcelona Spain"},{"name":"Unitat d'Al\u00b7l\u00e8rgia, Servei de Pneumologia, Hospital Cl\u00ednic Universitat de Barcelona Barcelona Spain"},{"name":"Centro de Investigaciones en Red de Enfermedades Respiratorias (CIBERES) Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Rueda","sequence":"additional","affiliation":[{"name":"Unitat d'Al\u00b7l\u00e8rgia, Servei de Pneumologia, Hospital Cl\u00ednic Universitat de Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Salcedo","sequence":"additional","affiliation":[{"name":"Centro 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