{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T12:54:15Z","timestamp":1778936055554,"version":"3.51.4"},"reference-count":34,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2012,9,21]],"date-time":"2012-09-21T00:00:00Z","timestamp":1348185600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Skin prick testing (<jats:styled-content style=\"fixed-case\">SPT<\/jats:styled-content>) is fundamental to the practice of clinical allergy identifying relevant allergens and predicting the clinical expression of disease. There are only limited data on the natural history of <jats:styled-content style=\"fixed-case\">SPT<\/jats:styled-content> results over childhood and adolescence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>We aimed to describe the natural history of <jats:styled-content style=\"fixed-case\">SPT<\/jats:styled-content> and patterns of sensitization over childhood and adolescence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The 1989 Isle of Wight birth cohort (1456 participants) was followed up at 1, 2, 4, 10 and 18\u00a0years. <jats:styled-content style=\"fixed-case\">SPT<\/jats:styled-content> was undertaken from 4\u00a0years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">SPT<\/jats:styled-content> was performed on 980 (80%), 1036 (75%) and 853 (65%) of participants at 4, 10 and 18\u00a0years. The prevalence of sensitization to any allergen at these time\u2010points was 19.7%, 26.9% and 41.3% respectively. At each time\u2010point, boys were significantly more likely to be sensitized (<jats:italic>P\u00a0&lt;<\/jats:italic>\u00a00.016) and sensitization significantly increased over childhood and adolescence (average annual increase of 7%). Some children outgrew their sensitization. The rate of sensitization to most individual allergens increased over childhood and adolescence. A configural frequency analysis showed that whether an individual was sensitizated was relatively fixed over childhood and adolescence. Cluster analysis at 4\u00a0years demonstrated four major groups of individuals with similar co\u2010sensitization to specific allergens. Children who were sensitized at age 4\u00a0years generally went onto become sensitized to additional allergens at 10 and 18\u00a0years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Clinical Relevance<\/jats:title><jats:p>Allergic sensitization continues to increase over childhood into adolescence although the majority of children who were not sensitized at 4\u00a0years remain non\u2010sensitized throughout childhood and adolescence. The presence of sensitization at 4\u00a0years predicted later sensitization to additional allergens.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1365-2222.2012.04074.x","type":"journal-article","created":{"date-parts":[[2012,7,24]],"date-time":"2012-07-24T05:04:18Z","timestamp":1343106258000},"page":"1501-1509","source":"Crossref","is-referenced-by-count":60,"title":["Trends in cutaneous sensitization in the first 18\u00a0years of life: results from the 1989 <scp>I<\/scp>sle of <scp>W<\/scp>ight birth cohort study"],"prefix":"10.1111","volume":"42","author":[{"given":"G.","family":"Roberts","sequence":"first","affiliation":[{"name":"The David Hide Asthma and Allergy Research Centre St Mary's Hospital Newport UK"},{"name":"University of Southampton Faculty of Medicine Southampton UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics Norman J. Arnold School of Public Health University of South Carolina Columbia SC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Karmaus","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics Norman J. Arnold School of Public Health University of South Carolina Columbia SC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Raza","sequence":"additional","affiliation":[{"name":"The David Hide Asthma and Allergy Research Centre St Mary's Hospital Newport UK"},{"name":"University of Southampton Faculty of Medicine Southampton UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Scott","sequence":"additional","affiliation":[{"name":"The David Hide Asthma and Allergy Research Centre St Mary's Hospital Newport UK"},{"name":"University of Southampton Faculty of Medicine Southampton UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Matthews","sequence":"additional","affiliation":[{"name":"The David Hide Asthma and Allergy Research Centre St Mary's Hospital Newport UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. J.","family":"Kurukulaaratchy","sequence":"additional","affiliation":[{"name":"The David Hide Asthma and Allergy Research Centre St Mary's Hospital Newport UK"},{"name":"University of Southampton Faculty of Medicine Southampton UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Dean","sequence":"additional","affiliation":[{"name":"The David Hide Asthma and Allergy Research Centre St Mary's Hospital Newport UK"},{"name":"University of Portsmouth Portsmouth UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. 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