{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T20:57:52Z","timestamp":1777409872627,"version":"3.51.4"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2010,6,1]],"date-time":"2010-06-01T00:00:00Z","timestamp":1275350400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,6,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>Background. Lichen planus (LP) is a mucocutaneous disease of unknown aetiology, which may involve the gastrointestinal (GI) mucosa. The association of Helicobacter pylori with LP has been a subject of debate.<\/jats:p>\n               <jats:p>Aim. To investigate upper GI findings and the presence of H. pylori in GI mucosa and oral LP (OLP).<\/jats:p>\n               <jats:p>Methods. Oral biopsies from 20 patients with erosive OLP and 20 with non-erosive OLP were investigated for the presence of H. pylori by histopathological examination and PCR. Upper GI endoscopy and GI mucosal biopsies were examined for LP lesions and\/or H. pylori.<\/jats:p>\n               <jats:p>Results. The endoscopic findings of both groups were oesophagitis, antral gastritis and duodenitis. No LP or LP-like changes were found in the upper GI mucosa. H. pylori was found by histopathological examination in the gastric mucosa of 18 patients (45%), with equal distribution in both the control and study groups. Positive PCR results were obtained from biopsy specimens of oral lesions in all patients with erosive OLP and presence of H. pylori in the stomach (9 patients), but in none of the patients with non-erosive OLP (P = 0.001).<\/jats:p>\n               <jats:p>Conclusion. We did not find any difference in symptoms, endoscopic findings and histopathological results between patients with erosive and non-erosive OLP. However, the concomitant presence of erosive OLP, of H. pylori nucleic acid in erosive OLP and the H. pylori organisms in gastric mucosa implies a possible pathogenic connection between this bacterium and erosive OLP.<\/jats:p>","DOI":"10.1111\/j.1365-2230.2009.03464.x","type":"journal-article","created":{"date-parts":[[2009,7,29]],"date-time":"2009-07-29T08:58:47Z","timestamp":1248857927000},"page":"355-360","source":"Crossref","is-referenced-by-count":26,"title":["Upper gastrointestinal findings and detection of <i>Helicobacter pylori<\/i> in patients with oral lichen planus"],"prefix":"10.1093","volume":"35","author":[{"given":"E. A. S.","family":"Attia","sequence":"first","affiliation":[{"name":"Departments of Dermatology and Venereology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. S. A.","family":"Abdel Fattah","sequence":"additional","affiliation":[{"name":"Departments of Dermatology and Venereology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. M.","family":"Abdella","sequence":"additional","affiliation":[{"name":"Tropical Medicine, Ain Shams University Hospitals, Cairo, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2010,6,1]]},"reference":[{"key":"2023013105382080200_b1","first-page":"31","article-title":"Upper gastrointestinal findings in oral lichen planus","volume":"13","author":"Sanli","year":"2002","journal-title":"Turk J Gastroenterol"},{"key":"2023013105382080200_b2","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1001\/archderm.1991.01680100084009","article-title":"Lichen planus and malignancy: an epidemiologic study of 2071 patients and a review of literature","volume":"127","author":"Sigurgeirsson","year":"1991","journal-title":"Arch Dermatol"},{"key":"2023013105382080200_b3","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1080\/000155500300012855","article-title":"Peptic ulcer and Helicobacter pylori in patients with lichen planus","volume":"80","author":"Vainio","year":"2000","journal-title":"Acta Derm Venereol"},{"key":"2023013105382080200_b4","doi-asserted-by":"crossref","first-page":"138","DOI":"10.4103\/0019-5154.35092","article-title":"Association of Helicobacter pylori with lichen planus","volume":"52","author":"Moravvej","year":"2007","journal-title":"Indian J Dermatol"},{"key":"2023013105382080200_b5","first-page":"1","article-title":"Treatment of Helicobacter pylori infection in Iran: low efficacy of recommended western regimens","volume":"7","author":"Malekzadeh","year":"2004","journal-title":"Arch Iranian Med"},{"key":"2023013105382080200_b6","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1111\/j.1523-5378.2005.00334.x","article-title":"Helicobacter pylori and extragastric diseases \u2013 other Helicobacter","volume":"10","author":"Nilsson","year":"2005","journal-title":"Helicobacter"},{"key":"2023013105382080200_b7","first-page":"91","article-title":"The relationship between the presence of Helicobacter pylori in the oral cavity and gastric in the stomach","volume":"57","author":"Loster","year":"2006","journal-title":"J Physiol Pharmacol"},{"key":"2023013105382080200_b8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1600-0714.1998.tb02081.x","article-title":"Detection of Helicobacter pylori in various oral lesions by nested polymerase chain reaction (PCR)","volume":"27","author":"Maravak-Stipetic","year":"1988","journal-title":"J Oral Pathol Med"},{"key":"2023013105382080200_b9","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1034\/j.1600-0714.2000.291005.x","article-title":"Detection of Helicobacter pylori DNA in recurrent aphthous stomatitis tissue by PCR","volume":"29","author":"Riggio","year":"2000","journal-title":"J Oral Pathol Med"},{"key":"2023013105382080200_b10","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1007\/BF01690093","article-title":"Influence of oropharyngeal flora and specimen pretreatment on the recovery of Helicobacter pylori","volume":"15","author":"Jonkers","year":"1996","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"2023013105382080200_b11","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1111\/j.1440-1746.1991.tb01469.x","article-title":"The Sydney system: endoscopic division, endoscopic appearance in gastritis-duodenitis","volume":"6","author":"Tytgat","year":"1991","journal-title":"J Gastroentrol Hepatol"},{"key":"2023013105382080200_b12","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1111\/j.1440-1746.1991.tb01468.x","article-title":"The Sydney System: histological division","volume":"6","author":"Price","year":"1991","journal-title":"J Gastroenterol Hepatol"},{"key":"2023013105382080200_b13","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1128\/CMR.00033-06","article-title":"Helicobacter pylori detection and antimicrobial susceptibility testing","volume":"20","author":"Me\u2019graud","year":"2007","journal-title":"Clin Microbiol Rev"},{"key":"2023013105382080200_b14","doi-asserted-by":"crossref","first-page":"89","DOI":"10.2334\/josnusd.49.89","article-title":"Oral lichen planus and lichenoid reactions: etiopathogenesis, diagnosis, management, and malignant transformation","volume":"49","author":"Ismail","year":"2007","journal-title":"J Oral Sci"},{"key":"2023013105382080200_b15","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1111\/j.1601-0825.2008.01441.x","article-title":"Oral lichen planus: controversies surrounding malignant transformation","volume":"14","author":"Gonzalez Moles","year":"2008","journal-title":"Oral Dis"},{"key":"2023013105382080200_b16","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1136\/bmj.300.6717.84","article-title":"The esophagus in lichen planus: an endoscopic study","volume":"300","author":"Dickens","year":"1990","journal-title":"BMJ"},{"key":"2023013105382080200_b17","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1001\/archderm.136.10.1275","article-title":"Association of Helicobacter pylori infection with psoriasis and lichen planus: prevalence and effect of eradication therapy","volume":"136","author":"Daud\u00e9n","year":"2000","journal-title":"Arch Dermatol"},{"key":"2023013105382080200_b18","first-page":"55","article-title":"The use of rapid urease test in diagnosis of Helicobacter pylori among~non ulcer dyspepsia patients in Egypt","volume":"1","author":"El-Zayadi","year":"1990","journal-title":"Journal of Tropical Medicine"},{"key":"2023013105382080200_b19","volume-title":"The prevalence of H. pylori antibodies in young Egyptian asymptomatic persons","author":"Salem","year":"1992"},{"key":"2023013105382080200_b20","doi-asserted-by":"crossref","first-page":"I9","DOI":"10.1136\/gut.45.2008.i9","article-title":"Extradigestive manifestations of Helicobacter pylori gastric infection","volume":"45","author":"Gasbarrini","year":"1999","journal-title":"Gut"},{"key":"2023013105382080200_b21","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1053\/gast.1996.v111.pm8780570","article-title":"Antigenic mimicry between Helicobacter pylori and gastric mucosa in the pathogenesis of body atrophic gastritis","volume":"111","author":"Negrini","year":"1996","journal-title":"Gastroenterology"},{"key":"2023013105382080200_b22","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.3109\/00365529309098317","article-title":"Local and systemic immune response in Helicobacter pylori-associated chronic gastritis before and after treatment","volume":"28","author":"Engstrand","year":"1993","journal-title":"Scand J Gastroenterol"},{"key":"2023013105382080200_b23","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1046\/j.1365-2133.1998.1390s3017.x","article-title":"The role of superantigens in human diseases: therapeutic implications for the treatment of skin diseases","volume":"139","author":"Leung","year":"1998","journal-title":"Br J Dermatol"},{"key":"2023013105382080200_b24","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1172\/JCI12672","article-title":"Helicobacter pylori genetic diversity and risk of human disease","volume":"107","author":"Blaser","year":"2001","journal-title":"J Clin Invest"}],"container-title":["Clinical and Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2230.2009.03464.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/ced\/article-pdf\/35\/4\/355\/48958259\/ced0355.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ced\/article-pdf\/35\/4\/355\/48958259\/ced0355.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T14:30:04Z","timestamp":1676385004000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ced\/article\/35\/4\/355\/6622408"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,6,1]]},"references-count":24,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2010,6,1]]},"published-print":{"date-parts":[[2010,6,1]]}},"URL":"https:\/\/doi.org\/10.1111\/j.1365-2230.2009.03464.x","relation":{},"ISSN":["1365-2230","0307-6938"],"issn-type":[{"value":"1365-2230","type":"electronic"},{"value":"0307-6938","type":"print"}],"subject":[],"published-other":{"date-parts":[[2010,6,1]]},"published":{"date-parts":[[2010,6,1]]}}}