{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T15:03:26Z","timestamp":1774451006205,"version":"3.50.1"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2011,7,1]],"date-time":"2011-07-01T00:00:00Z","timestamp":1309478400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,7,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>Background. Corticosteroids, especially prednisolone or prednisone, are the most commonly used drugs for the treatment of bullous pemphigoid (BP). However, the appropriate initial effective prednisolone dose has not been established. Recently, a highly sensitive and specific ELISA for detection of autoantibodies to the non-collagenous extracellular domain (NC16A) of the 180 kDa transmembrane hemidesmosome component [bullous pemphigoid (BP)180] was developed, and the titre of anti-BP180 antibody was found to be closely related to disease activity.<\/jats:p>\n               <jats:p>Aim. To investigate the relationship between anti-BP180 antibody titre and effective prednisolone dose alone or in conjunction with other immunosuppressants.<\/jats:p>\n               <jats:p>Methods. Anti-BP180 antibody titres were measured by ELISA for the NC16A domain of BP180 in the sera of patients with BP (n = 42) at the start of treatment. The effective prednisolone dose was calculated from the patients\u2019 records.<\/jats:p>\n               <jats:p>Results. Higher anti-BP180 antibody titres correlated with a higher effective prednisolone dose. In particular, patients with antibody titres &amp;gt; 200 required a significantly higher effective prednisolone dose than did those with antibody titres \u2264 200.<\/jats:p>\n               <jats:p>Conclusions. A higher effective prednisolone dose may be necessary for patients who have both a high titre of anti-BP180 antibody and severe clinical disease.<\/jats:p>","DOI":"10.1111\/j.1365-2230.2010.04013.x","type":"journal-article","created":{"date-parts":[[2011,3,11]],"date-time":"2011-03-11T10:03:11Z","timestamp":1299837791000},"page":"485-488","source":"Crossref","is-referenced-by-count":5,"title":["Association between effective dose of prednisolone, alone or in conjunction with other immunosuppressants, and titre of anti-bullous pemphigoid 180 antibody: a retrospective study of 42 cases"],"prefix":"10.1093","volume":"36","author":[{"given":"H.","family":"Miida","sequence":"first","affiliation":[{"name":"Division of Dermatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Fujiwara","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Ito","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2011,7,1]]},"reference":[{"key":"2023012703540866600_b1","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1046\/j.1365-2133.2002.04835.x","article-title":"Guidelines for the management of bullous pemphigoid","volume":"147","author":"Wojnarowska","year":"2002","journal-title":"Br J Dermatol"},{"key":"2023012703540866600_b2","first-page":"25","volume-title":"Rook\u2019s Textbook of Dermatology","author":"Wojnarowska","year":"2004"},{"key":"2023012703540866600_b3","doi-asserted-by":"crossref","first-page":"5742","DOI":"10.4049\/jimmunol.151.10.5742","article-title":"Bullous pemphigoid and herpes gestationis autoantibodies recognize a common non-collagenous site on the BP180 ectodomain","volume":"151","author":"Giudice","year":"1993","journal-title":"J Immunol"},{"key":"2023012703540866600_b4","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.jdermsci.2004.10.007","article-title":"Correlation of clinical severity and ELISA indices for the NC16A domain of BP180 measured using BP180 ELISA kit in bullous pemphigoid","volume":"37","author":"Tsuji-Abe","year":"2004","journal-title":"J Dermatol Sci"},{"key":"2023012703540866600_b5","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1111\/j.1365-4632.2008.03473.x","article-title":"Serum levels of autoantibodies to BP180 correlate with disease activity in patients with bullous pemphigoid","volume":"47","author":"Feng","year":"2008","journal-title":"Int J Dermatol"},{"key":"2023012703540866600_b6","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1001\/archderm.136.2.174","article-title":"Serum levels of autoantibodies to BP180 correlate with disease activity in patients with bullous pemphigoid","volume":"136","author":"Schmidt","year":"2000","journal-title":"Arch Dermatol"},{"key":"2023012703540866600_b7","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1056\/NEJMoa011592","article-title":"A comparison of oral and topical corticosteroids in patients with bullous pemphigoid","volume":"346","author":"Joly","year":"2002","journal-title":"N Engl J Med"},{"key":"2023012703540866600_b8","first-page":"925","article-title":"Treatment of bullous pemphigoid with prednisolone only: 0.75 mg\/kg\/day versus 1.25 mg\/kg\/day. 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