{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T21:36:50Z","timestamp":1791149810438,"version":"4.1.0"},"reference-count":13,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T00:00:00Z","timestamp":1322697600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,12,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Background. Psoriasis is a chronic, systemic, inflammatory disease. Inflammatory markers are used in clinical practice to detect acute inflammation, and as markers of treatment response. Etanercept blocks tumour necrosis factor (TNF)-\u03b1, which plays a central role in the psoriatic inflammation process.<\/jats:p><jats:p>Aim. To reveal any possible association between disease severity [measured by Psoriasis Area and Severity Index (PASI)] and the inflammatory burden (measured by a group of inflammatory markers), before and after etanercept treatment.<\/jats:p><jats:p>Methods. In total, 41 patients with psoriasis vulgaris, eligible for biological treatment with etanercept, were enrolled in the study. A set of inflammatory markers was measured, including levels of white blood cells and neutrophils, fibrinogen, ferritin, high-sensitivity C-reactive protein (hs-CRP), erythrocyte sedimentation rate (ESR), haptoglobin, ceruloplasmin and \u03b11-antitrypsin, before and after 12 weeks of etanercept 50 mg twice weekly.<\/jats:p><jats:p>Results. All markers were reduced after treatment (P &amp;lt; 0.001). PASI correlated with fibrinogen and hs-CRP. Of the 41 patients, 19 (46.3%) achieved reduction of 75% in PASI (PASI75). An increase in hs-CRP and ESR difference (values before minus values after treatment) was related to higher likelihood of achieving PASI75.<\/jats:p><jats:p>Conclusions. Inflammatory markers, particularly hs-CRP and to a lesser extent, fibrinogen and ESR, can be used to assist in assessing disease severity and response to treatment in patients with psoriasis. A combination of selected inflammatory factors (which we term the Index of Psoriasis Inflammation) in combination with PASI might reflect inflammatory status in psoriasis more accurately than each one separately.<\/jats:p>","DOI":"10.1111\/j.1365-2230.2011.04131.x","type":"journal-article","created":{"date-parts":[[2011,7,26]],"date-time":"2011-07-26T13:52:23Z","timestamp":1311688343000},"page":"845-850","source":"Crossref","is-referenced-by-count":51,"title":["The role of inflammatory markers in assessing disease severity and response to treatment in patients with psoriasis treated with etanercept"],"prefix":"10.1093","volume":"36","author":[{"given":"A.","family":"Kanelleas","sequence":"first","affiliation":[{"name":"Second Department of Dermatology and Venereology, Attikon University General Hospital, School of Medicine, National and Kapodistrian University of Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Liapi","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Medicine, National and Kapodistrian University of Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Katoulis","sequence":"additional","affiliation":[{"name":"Second Department of Dermatology and Venereology, Attikon University General Hospital, School of Medicine, National and Kapodistrian University of Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Stavropoulos","sequence":"additional","affiliation":[{"name":"First Department of Dermatology and Venereology, A. Sygros Hospital, School of Medicine, National and Kapodistrian University of Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Avgerinou","sequence":"additional","affiliation":[{"name":"First Department of Dermatology and Venereology, A. Sygros Hospital, School of Medicine, National and Kapodistrian University of Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Georgala","sequence":"additional","affiliation":[{"name":"First Department of Dermatology and Venereology, A. Sygros Hospital, School of Medicine, National and Kapodistrian University of Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Economopoulos","sequence":"additional","affiliation":[{"name":"Second Department of Internal Medicine, Attikon University General Hospital, School of Medicine, National and Kapodistrian University of Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. G.","family":"Stavrianeas","sequence":"additional","affiliation":[{"name":"Second Department of Dermatology and Venereology, Attikon University General Hospital, School of Medicine, National and Kapodistrian University of Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Katsambas","sequence":"additional","affiliation":[{"name":"First Department of Dermatology and Venereology, A. 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