{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T20:02:34Z","timestamp":1789588954331,"version":"build-2803163510"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T00:00:00Z","timestamp":1322697600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,12,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>Background. Using both vertical and transverse sections is preferred for histopathological diagnosis of alopecia. However, in cases in which only a single biopsy is taken, it is not clear which type of sectioning is better.<\/jats:p>\n               <jats:p>Aim. To compare the diagnostic value of transverse and vertical sections.<\/jats:p>\n               <jats:p>Methods. In total, 53 patients with alopecia were enrolled in the study. Two biopsies were taken from each patient, and cut into either transverse or vertical sections. The clinical and histopathological findings were evaluated together for the definitive diagnosis. After the study period, a pathologist randomly re-evaluated the sections. We compared the histopathological diagnoses with the definitive diagnoses, and determined the sensitivity and specificity of each method.<\/jats:p>\n               <jats:p>Results. A definitive diagnosis was made for 47 patients (88.7%). Of these, 30 (63.8%) had noncicatricial and 17 (36.2%) had cicatricial alopecia, and the diagnosis was made by transverse and vertical sections for 43 (91.5%) and 39 (88%), respectively (P &amp;gt; 0.05; sensitivity; 91.5% vs. 82%). All 30 patients with noncicatricial alopecia were diagnosed by transverse sections, and 25 (83.3%) of the 30 were diagnosed with vertical sections (P = 0.05; sensitivity 100% vs. 83.3%). Of the 17 patients with cicatricial alopecia, 13 (76.5%) and 14 (82.4%) patients were diagnosed by transverse and vertical sections, respectively (P &amp;gt; 0.05; sensitivity 76.5% vs. 82.4%). Five patients with lichen planopilaris were diagnosed by vertical sections, and one by transverse sections. There were several limitations to the study: (i) statistical subtype analysis could be performed only for alopecia areata; (ii) no conclusion could be drawn about the interobserver reliability of two sections; and (iii) having the pathologist-blinded study performed retrospectively might have caused a recall bias.<\/jats:p>\n               <jats:p>Conclusion. If only a single biopsy specimen is available, it may be preferable to have transverse sections in cases of suspected noncicatricial alopecia, and vertical sections in cases of suspected lichen planopilaris. Either type of sectioning is suitable for cicatricial alopecia when lichen planopilaris is clinically unlikely.<\/jats:p>","DOI":"10.1111\/j.1365-2230.2011.04154.x","type":"journal-article","created":{"date-parts":[[2011,9,15]],"date-time":"2011-09-15T20:37:06Z","timestamp":1316119026000},"page":"855-863","source":"Crossref","is-referenced-by-count":18,"title":["Vertical vs. transverse sections of scalp biopsy specimens: a pilot study on the comparison of the diagnostic value of two techniques in alopecia"],"prefix":"10.1093","volume":"36","author":[{"given":"D.","family":"\u00d6zcan","sequence":"first","affiliation":[{"name":"Departments of Dermatology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d6.","family":"\u00d6zen","sequence":"additional","affiliation":[{"name":"Pathology, Ba\u015fkent University Faculty of Medicine, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Se\u00e7kin","sequence":"additional","affiliation":[{"name":"Departments of Dermatology"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2011,12,1]]},"reference":[{"key":"2023012703541886800_b1","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1097\/00000372-200606000-00051","article-title":"Histopathologic evaluation of alopecias","volume":"28","author":"Sellheyer","year":"2006","journal-title":"Am J Dermatopathol"},{"key":"2023012703541886800_b2","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.sder.2006.01.006","article-title":"The histopathology of primary cicatricial alopecia","volume":"25","author":"Sperling","year":"2006","journal-title":"Semin Cutan Med Surg"},{"key":"2023012703541886800_b3","first-page":"93","article-title":"Common hair loss disorders","volume":"68","author":"Springer","year":"2003","journal-title":"Am Fam Physician"},{"key":"2023012703541886800_b4","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.sder.2006.01.003","article-title":"Clinical approach to the patient with alopecia","volume":"25","author":"Han","year":"2006","journal-title":"Semin Cutan Med Surg"},{"key":"2023012703541886800_b5","first-page":"2","article-title":"Alopecia: histologic diagnosis by transverse sections","volume":"13","author":"Templeton","year":"1996","journal-title":"Semin Diagn Pathol"},{"key":"2023012703541886800_b6","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/0190-9622(95)90068-3","article-title":"Vertical and transverse sections of alopecia biopsy specimens: combining two to maximize diagnostic yield","volume":"32","author":"Elston","year":"1995","journal-title":"J Am Acad Dermatol"},{"key":"2023012703541886800_b7","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1097\/01.dad.0000154398.60712.11","article-title":"Transverse sections for diagnosis of alopecia?","volume":"27","author":"B\u00f6er","year":"2005","journal-title":"Am J Dermatopathol"},{"key":"2023012703541886800_b8","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1097\/01.dad.0000164602.10908.92","article-title":"Vertical vs. transverse sections: both are valuable in the evaluation of alopecia","volume":"27","author":"Elston","year":"2005","journal-title":"Am J Dermatopathol"},{"key":"2023012703541886800_b9","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1111\/j.1600-0560.1994.tb00243.x","article-title":"Scarring alopecia: a classification based on microscopic criteria","volume":"21","author":"Templeton","year":"1994","journal-title":"J Cutan Pathol"},{"key":"2023012703541886800_b10","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1001\/archderm.1984.01650400031009","article-title":"Transverse microscopic anatomy of the human scalp","volume":"120","author":"Headington","year":"1984","journal-title":"Arch Dermatol"},{"key":"2023012703541886800_b11","first-page":"127","article-title":"The transversely sectioned scalp biopsy specimen: the technique and an algorithm for its use in the diagnosis of alopecia","volume":"9","author":"Solomon","year":"1994","journal-title":"Adv Dermatol"},{"key":"2023012703541886800_b12","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/S0190-9622(96)90328-X","article-title":"Transverse scalp sections: a proposed method for laboratory processing","volume":"35","author":"Frishberg","year":"1996","journal-title":"J Am Acad Dermatol"},{"key":"2023012703541886800_b13","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0190-9622(03)00045-8","article-title":"The reliability of horizontally sectioned scalp biopsies in the diagnosis of chronic diffuse telogen hair loss in women","volume":"51","author":"Sinclair","year":"2004","journal-title":"J Am Acad Dermatol"},{"key":"2023012703541886800_b14","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0738-081X(00)00132-2","article-title":"Cicatricial alopecia: clinico-pathological findings and treatment","volume":"19","author":"Whiting","year":"2001","journal-title":"Clin Dermatol"},{"key":"2023012703541886800_b15","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.sder.2006.01.005","article-title":"The histopathology of noncicatricial alopecia","volume":"25","author":"Eudy","year":"2006","journal-title":"Semin Cutan Med Surg"},{"key":"2023012703541886800_b16","doi-asserted-by":"crossref","DOI":"10.3109\/9780203490662","volume-title":"An Atlas of Hair Pathology with Clinical Correlations","author":"Sperling","year":"2003"},{"key":"2023012703541886800_b17","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1067\/mjd.2003.68","article-title":"Summary of North American Hair Research Society (NAHRS) Sponsored Workshop on Cicatricial Alopecia. Duke University Medical Center, February 10 and 11, 2001","volume":"48","author":"Olsen","year":"2003","journal-title":"J Am Acad Dermatol"},{"key":"2023012703541886800_b18","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1111\/j.1445-5994.2007.01436.x","article-title":"Cautionary tales in the clinical interpretation of studies of diagnostic tests","volume":"38","author":"Scott","year":"2008","journal-title":"Intern Med J"},{"key":"2023012703541886800_b19","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.jaad.2005.03.007","article-title":"A comparison of vertical versus transverse sections in the evaluation of alopecia biopsy specimens","volume":"53","author":"Elston","year":"2005","journal-title":"J Am Acad Dermatol"},{"key":"2023012703541886800_b20","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.1038\/jid.1995.46","article-title":"Histopathology of alopecia areata in horizontal sections of scalp biopsies","volume":"104","author":"Whiting","year":"1995","journal-title":"J Invest Dermatol"},{"key":"2023012703541886800_b21","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/0190-9622(93)70106-4","article-title":"Diagnostic and predictive value of horizontal sections of scalp biopsy specimens in male pattern androgenetic alopecia","volume":"28","author":"Whiting","year":"1993","journal-title":"J Am Acad Dermatol"},{"key":"2023012703541886800_b22","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1001\/archderm.1993.01680240096017","article-title":"Telogen effluvium. New concepts and review","volume":"129","author":"Headington","year":"1993","journal-title":"Arch Dermatol"},{"key":"2023012703541886800_b23","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1001\/archderm.139.12.1555","article-title":"Histopathologic features of alopecia areata: a new look","volume":"139","author":"Whiting","year":"2003","journal-title":"Arch Dermatol"},{"key":"2023012703541886800_b24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jaad.2004.06.015","article-title":"Update on primary cicatricial alopecias","volume":"53","author":"Ross","year":"2005","journal-title":"J Am Acad Dermatol"},{"key":"2023012703541886800_b25","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.jaad.2004.07.069","article-title":"Primary cicatricial alopecia: histopathological findings do not distinguish clinical variants","volume":"52","author":"Mirmirani","year":"2005","journal-title":"J Am Acad Dermatol"}],"container-title":["Clinical and Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2230.2011.04154.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/ced\/article-pdf\/36\/8\/855\/46914925\/ced0855.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ced\/article-pdf\/36\/8\/855\/46914925\/ced0855.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,27]],"date-time":"2023-01-27T04:12:56Z","timestamp":1674792776000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ced\/article\/36\/8\/855\/6622452"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12,1]]},"references-count":25,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2011,12,1]]},"published-print":{"date-parts":[[2011,12,1]]}},"URL":"https:\/\/doi.org\/10.1111\/j.1365-2230.2011.04154.x","relation":{},"ISSN":["1365-2230","0307-6938"],"issn-type":[{"value":"1365-2230","type":"electronic"},{"value":"0307-6938","type":"print"}],"subject":[],"published-other":{"date-parts":[[2011,12,1]]},"published":{"date-parts":[[2011,12,1]]}}}