{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T02:23:35Z","timestamp":1782786215117,"version":"3.54.5"},"reference-count":14,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T00:00:00Z","timestamp":1322697600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,12,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>Background. Cytotoxic T lymphocytes (CTLs) have been recognized as an important effector cell in Beh\u00e7et disease (BD). Granulysin is a cytolytic granule protein expressed by CTLs and natural killer cells.<\/jats:p>\n               <jats:p>Aim. To evaluate the involvement of granulysin-producing T cells in the pathogenesis of BD.<\/jats:p>\n               <jats:p>Methods. Using immunohistochemistry, lymphocyte subsets expressing granulysin were investigated in mucocutaneous lesions of BD. Serum granulysin levels were assayed by ELISA.<\/jats:p>\n               <jats:p>Results. Granulysin-positive cells were seen in specimens from oral ulcers, genital ulcers and acne-like eruptions, but not erythema nodosum-like lesions. Both CD4+ and CD8+ T cells expressed granulysin. Serum granulysin levels did not correlate with disease activity in BD.<\/jats:p>\n               <jats:p>Conclusion. Immune reactions mediated by granulysin-positive CTLs may play an important role in the pathogenesis of acne-like eruptions, oral ulcers and genital ulcers in BD.<\/jats:p>","DOI":"10.1111\/j.1365-2230.2011.04159.x","type":"journal-article","created":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T02:33:36Z","timestamp":1314844416000},"page":"903-907","source":"Crossref","is-referenced-by-count":5,"title":["Granulysin-producing cytotoxic T cells in the mucocutaneous lesions of Beh\u00e7et disease: a distinct inflammatory response from erythema nodosum"],"prefix":"10.1093","volume":"36","author":[{"given":"O.","family":"Yamasaki","sequence":"first","affiliation":[{"name":"Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science, Okayama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Morizane","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science, Okayama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Aochi","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science, Okayama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Ogawa","sequence":"additional","affiliation":[{"name":"R & D Center, BML, Saitama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Oono","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science, Okayama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Iwatsuki","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry and 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