{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,4,20]],"date-time":"2023-04-20T04:43:45Z","timestamp":1681965825402},"reference-count":18,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2013,4,1]],"date-time":"2013-04-01T00:00:00Z","timestamp":1364774400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,4,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>Background. Rapid skin warming and prompt correct medical treatment lead to dramatic improvement in patients with peripheral capillary-related damage, such as injuries, Raynaud disease and frostbite.<\/jats:p>\n               <jats:p>Aim. To characterize a novel composite, NXCL-4950, for use in a cosmetic lotion.<\/jats:p>\n               <jats:p>Methods. The effects of NXCL-4950 on enhancing skin blood flow, skin temperature warming, and expansion of peripheral blood vessels and scalp microvessels were investigated.<\/jats:p>\n               <jats:p>Results. Monitoring by laser Doppler perfusion imaging and thermal imaging showed that application of NXCL-4950 to the hands increased skin blood flow and temperature relative to the control (or placebo) group. For the 20 participants with a high Raynaud Condition Score, application of NXCL-4950 to the skin resulted in a mean increase of 215.53% in microvessel diameter and mean increase of 164.96% in the speed of blood flow. When NXCL-4950 was applied to the scalp, the microvessels around the hair roots were clearly visible after 20 min.<\/jats:p>\n               <jats:p>Conclusion. NXCL-4950 is a potential candidate for enhancing peripheral skin temperature, and might be useful in the treatment of capillary-related disorders.<\/jats:p>","DOI":"10.1111\/j.1365-2230.2012.04371.x","type":"journal-article","created":{"date-parts":[[2012,9,25]],"date-time":"2012-09-25T20:02:33Z","timestamp":1348603353000},"page":"244-250","source":"Crossref","is-referenced-by-count":2,"title":["NXCL-4950, a novel composite applicable to peripheral skin, is capable of increasing skin temperature by enhancing capillary circulation"],"prefix":"10.1093","volume":"38","author":[{"given":"D.-C.","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Biomedical Laboratory Science, Gimcheon University, Gimcheon, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.-E.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Cosmeceutical Science, Daegu Haany University, Gyungsan, 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