{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:43:45Z","timestamp":1777387425116,"version":"3.51.4"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[1990,8,1]],"date-time":"1990-08-01T00:00:00Z","timestamp":649468800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,6,28]]},"abstract":"<jats:title>SUMMARY<\/jats:title>\n               <jats:p>The expression of tumour necrosis factor-alpha (TNF-\u03b1) gene in peripheral blood mononuclear cells from patients with systemic vasculitis. periarteritis nodosa and Wegener's granulomatosis, has been studied by RNA dot blot and Northern blot assays. We further examined the transcriptional level of TNF-\u03b1 gene in peripheral blood mononuclear cells from these patients by performing nuclear run on transcription assay. We demonstrate enhanced TNF-\u03b1 gene expression in mononuclear cells from these patients compared with healthy subjects and patients with bronchial asthma. These findings suggest that the enhanced transcription of TNF-\u03b1 gene in peripheral blood mononuclear cells from patients with systemic vasculitis may be involved in the pathophysiology\/pathogenesis of these diseases by cylokine dysregulation.<\/jats:p>","DOI":"10.1111\/j.1365-2249.1990.tb03336.x","type":"journal-article","created":{"date-parts":[[2010,7,26]],"date-time":"2010-07-26T21:39:40Z","timestamp":1280180380000},"page":"311-314","source":"Crossref","is-referenced-by-count":55,"title":["Enhanced expression of the tumour necrosis factor\/cachectin gene in peripheral blood mononuclear cells from patients with systemic vasculitis"],"prefix":"10.1093","volume":"81","author":[{"given":"Y","family":"DEGUCHI","sequence":"first","affiliation":[{"name":"Third Department of Internal Medicine, Osaka University School of Medicine, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"SHIBATA","sequence":"additional","affiliation":[{"name":"Division of Internal Medicine, Centre for Adult Diseases, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"KISHIMOTO","sequence":"additional","affiliation":[{"name":"Third Department of Internal Medicine, Osaka University School of Medicine, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2008,6,28]]},"reference":[{"key":"2022011713333997600_b1","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1056\/NEJM198702123160705","article-title":"Cachectin: more than a tumor necrosis factor","volume":"316","author":"Beutler","year":"1987","journal-title":"N. 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