{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T23:51:13Z","timestamp":1773273073543,"version":"3.50.1"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[1990,3,1]],"date-time":"1990-03-01T00:00:00Z","timestamp":636249600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,6,28]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>Distinct expression pattern of CD10 molecules during B cell activation was analysed using in vivo and in vitro systems. By two-colour flowcytometrical analysis, CD10 was found to be expressed at a specificstage of in vivo activating B cells. The expression of CD10 during B cell activation appeared to be unique from that of other activation-related B cell antigens including L29, MA6, OKT9 and OKT10. Although the expression of CD10 was associated with that of the activation-related B cell antigens, CD 10+ B cells could be separated in the distinct fractions to those expressing other activation-related B cell antigens when fractionated by cell gravity. In particular, certain CD10+ B cells were detected positive for the resting B cell antigen, L30. In vitro studies revealed that CD10+ B cells arose from CD10- B cells at an early step of B cell activation, and disappeared lately when activated by Staphylococcus aureus Cowan I. Collectively, CD10 was an antigen transiently expressed at an early phase of B cell activation process. Expression of CD10 and other antigens on Burkitt's lymphomas (15 cases) was studied next. All cases were CD10+, and 87% (13 cases) were also L30+. In addition, six of CD10+ L30+ cases were L29+. This observation suggested that Burkitt's lymphomas were phenotypically similar to the B cells at an early phase of activation, those expressing CD10 and L30, simultaneously. The present study has dissected a precise expression pattern of CD10 on mature B cell activation in vitro and in vivo, and could be implicated for the histogenesis of one of the poorly characterized B cell lymphoma, namely Burkitt's lymphoma.<\/jats:p>","DOI":"10.1111\/j.1365-2249.1990.tb08090.x","type":"journal-article","created":{"date-parts":[[2010,7,26]],"date-time":"2010-07-26T21:39:16Z","timestamp":1280180356000},"page":"322-327","source":"Crossref","is-referenced-by-count":28,"title":["Characterization of the common acute lymphoblastic leukaemia antigen (CD10) as an activation molecule on mature human B cells"],"prefix":"10.1093","volume":"79","author":[{"given":"N","family":"KIYOKAWA","sequence":"first","affiliation":[{"name":"Department of Pathology, National Children's Medical Research Centre, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"KOKAI","sequence":"additional","affiliation":[{"name":"Department of Pathology, National Children's Medical Research Centre, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"ISHIMOTO","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Juntendo University School of Medicine, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"FUJITA","sequence":"additional","affiliation":[{"name":"Department of Pathology, National Children's Medical Research Centre, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"FUJIMOTO","sequence":"additional","affiliation":[{"name":"Department of Pathology, National Children's Medical Research Centre, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J-I","family":"HATA","sequence":"additional","affiliation":[{"name":"Department of Pathology, National Children's Medical Research Centre, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2008,6,28]]},"reference":[{"key":"2022011713432233100_b1","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/0090-1229(81)90193-8","article-title":"Human B lymphocyte subpopulations, I. 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