{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T12:10:21Z","timestamp":1764331821096},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[1995,1,1]],"date-time":"1995-01-01T00:00:00Z","timestamp":788918400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,6,28]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>IgG antibodies to a 57-kD protein (p57) present in various human and bovine extracts were detected by immunoblotting in the serum of the mother of a baby with congenital heart block, but not in the corresponding cord blood, suggesting specific antibody consumption in the baby. Since this indicates a possible functional role for these antibodies, the antigen target was characterized and the association of the antibodies to heart block was further studied. A human K562 \u03bbgt11 cDNA library was screened and two clones were identified whose products reacted with the prototype serum. Antibody affinity-purified by use of the cloned gene products reacted on immunoblot with the 57-kD band. Partial sequences of both inserts were identical, but differed from DNA encoding the Ro(SSA) and La(SSB) antigens. Antibodies to the p57 were detected in 10% of systemic lupus erythematosus (SLE) sera, almost exclusively in association with anti-Ro(SSA). Furthermore, they were present in 38% (8\/21) mothers of babies with neonatal lupus expressing either cardiac or cutaneous manifestations. Antibodies to this 57-kD protein may be an additional risk factor for neonatal lupus in anti-Ro-positive women. Moreover, disappearance of antibody from cord blood suggests that they may have a role in disease manifestations.<\/jats:p>","DOI":"10.1111\/j.1365-2249.1995.tb03470.x","type":"journal-article","created":{"date-parts":[[2010,7,26]],"date-time":"2010-07-26T17:51:52Z","timestamp":1280166712000},"page":"42-48","source":"Crossref","is-referenced-by-count":29,"title":["Anti-p57: a novel association with neonatal lupus"],"prefix":"10.1093","volume":"99","author":[{"given":"P J","family":"Maddison","sequence":"first","affiliation":[{"name":"Royal National Hospital for Rheumatic Disease, Bath, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Oklahoma University Health Sciences Centre, Oklahoma City, OK, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Reichlin","sequence":"additional","affiliation":[{"name":"Arthritis Immunology Program, Oklahoma Medical Research Foundation, Department of Medicine, College of Medicine, Oklahoma University Health Sciences Centre, Oklahoma City, OK, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Sinclair","sequence":"additional","affiliation":[{"name":"Arthritis Immunology Program, Oklahoma Medical Research Foundation, Department of Medicine, College of Medicine, Oklahoma University Health Sciences Centre, Oklahoma City, OK, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Wasson","sequence":"additional","affiliation":[{"name":"Arthritis Immunology Program, Oklahoma Medical Research Foundation, Department of Medicine, College of Medicine, Oklahoma University Health Sciences Centre, Oklahoma City, OK, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Schemmer","sequence":"additional","affiliation":[{"name":"Thomas Jefferson Medical College, Philadelphia, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Reichlin","sequence":"additional","affiliation":[{"name":"Arthritis Immunology Program, Oklahoma Medical Research Foundation, Department of Medicine, College of Medicine, Oklahoma University Health Sciences Centre, Oklahoma City, OK, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2008,6,28]]},"reference":[{"key":"2022011517425696300_b1","doi-asserted-by":"crossref","first-page":"9S","DOI":"10.1038\/jid.1993.17","article-title":"Neonatal lupus erythematosus","volume":"100","author":"Lee","year":"1993","journal-title":"J Invest Dermatol"},{"key":"2022011517425696300_b2","first-page":"85","article-title":"Congenital complete heart block: an international study of the natural history","volume-title":"Pediatric cardiology","author":"Michaelsson","year":"1972"},{"key":"2022011517425696300_b3","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1001\/archderm.1979.04010120007006","article-title":"Subacute cutaneous lupus erythematosus: a cutaneous marker for a distinct lupus erythematosus subset","volume":"115","author":"Sontheimer","year":"1979","journal-title":"Arch Dermatol"},{"key":"2022011517425696300_b4","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/0738-081X(85)90075-6","article-title":"Pathogenesis of cutaneous lupus erythematosus","volume":"3","author":"Norris","year":"1985","journal-title":"Clin Dermatol"},{"key":"2022011517425696300_b5","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1177\/096120339300200503","article-title":"Congenital complete heart block","volume":"2","author":"Buyon","year":"1993","journal-title":"Lupus"},{"key":"2022011517425696300_b6","first-page":"1329","article-title":"Maternal connective tissue disease and congenital heart block","volume":"312","author":"Herreman","year":"1985","journal-title":"N Engl J Med"},{"key":"2022011517425696300_b7","first-page":"667","article-title":"Maternal connective tissue disease and congenital heart block. 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