{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T12:48:14Z","timestamp":1790254094853,"version":"4.1.0"},"reference-count":55,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[1995,1,1]],"date-time":"1995-01-01T00:00:00Z","timestamp":788918400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,6,28]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>The intestinal population of \u03b3\u03b4 T cell receptor (TCR)-bearing cells was characterized with regard to V\u03b4 and V\u03b3 subtype expression. For this purpose, we utilized V gene-specific PCR of mRNA prepared from intestinal biopsies. Predominant expression of the V\u03b41 subtype was demonstrated in the small intestine of patients with coeliac disease and in the inflamed colon of patients with inflammatory bowel diseases (IBD: ulcerative colitis and Crohn's disease) as well as in colon biopsies taken from macroscopically normal areas of colon. Although intestinal \u03b3\u03b4 T cells preferentially expressed V\u03b41, other V\u03b4 transcripts could be detected, of which V\u03b42 and V\u03b45 were commonly expressed. Analysis of biopsies from mesenteric lymph nodes demonstrated a V\u03b4 repertoire similar to the mucosa. In peripheral blood on the other hand, high expression of both V\u03b42 and V\u03b41 was found. The predominant expression of V\u03b41 transcripts in the intestinal mucosa of IBD patients correlated well with protein cell surface expression as analysed by flow cytometry using V\u03b41- and V\u03b42-specific antibodies. Selective expansion of \u03b3\u03b4 T cells could not be demonstrated within the inflamed mucosa as shown by mRNA analysis and flow cytometry. Instead, IBD patients demonstrated a decreased proportion of TCR 76-carrying T cells in the inflamed mucosa compared with macroscopically normal area of colon. On the other hand, a significantly increased percentage of T cells bearing the \u03b3\u03b4 TCR was found in peripheral blood of patients with Crohn's disease compared with healthy individuals, indicating that local mucosal inflammation may influence the circulating \u03b3\u03b4 T cell population.<\/jats:p>","DOI":"10.1111\/j.1365-2249.1995.tb03472.x","type":"journal-article","created":{"date-parts":[[2010,7,26]],"date-time":"2010-07-26T21:10:20Z","timestamp":1280178620000},"page":"57-64","source":"Crossref","is-referenced-by-count":37,"title":["Analysis of \u03b3\u03b4 region usage in normal and diseased human intestinal biopsies and peripheral blood by polymerase chain reaction (PCR) and flow cytometry"],"prefix":"10.1093","volume":"99","author":[{"given":"A","family":"Bucht","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Pharmacia Therapeutics, Uppsala University Hospital, Uppsala, Sweden"},{"name":"Department of Clinical Immunology, Uppsala University 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