{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:05:01Z","timestamp":1761059101792},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[1995,12,1]],"date-time":"1995-12-01T00:00:00Z","timestamp":817776000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,6,28]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>The aim of this study was to determine the developmental profile of mannose-binding protein (MBP) in preterm infants. MBP was measured in 885 longitudinally collected serum samples from 168 preterm infants, and 63 were genotyped with respect to the codon 54 mutation in the MBP gene. MBP level\/codon 54 genotyping were also determined on the cord blood of 146\/123 term infants and 138\/123 adults, respectively. The best cut-off values of MBP for dividing preterm, term infants and adults into \u2018low\u2019 and \u2018high\u2019 M BP groups were 400 ng\/ml (55 low, 113 high), 700 ng\/ml (35 low, 111 high) and 750 ng\/ml (33 low. 105 high), respectively, by achieving the least number of misclassifications according to the codon 54 mutation. The relative risk of the \u2018low\u2019 groups for presence of the codon 54 mutation compared with \u2018high\u2019 groups were 42 4, 67\u20139 and 22\u20139 for preterm, term infants and adults, respectively (P KO 00001). The gestational age and birth weight of the \u2018low\u2019(n = 55) and \u2018high\u2019(n= 113) MBP groups of the 168 preterm infants were 29.5 \u00b1 2.8 weeks, 30.5\u00b12.8 weeks (p=0.03) and 1230\u00b1317g, 1277\u00b1289g (p = 0.35). respectively. The mean MBP levels of these two groups of preterm infants were different (P&amp;lt;0001) at all ages measured. As a whole group, the MBP level rose from a mean of 500 ng\/ml at 25 weeks gestation to 1700ng\/ml at 20 weeks post full-term. The mortality rates of \u2018low\u2019 and \u2018high\u2019 MBP groups of preterm infants were 22% and 12%, respectively (p-0.113). This difference in mortality was due to gestational age and birth weight standard deviation score (SDS) after adjusting for length of gestation and gender (p = 0.0001) rather than to low MBP levels (p = 0 65). MBP levels were not related to birthweight SDS score (P = 0 26). The mean \u00b1 sd. MBP levels for preterm, term infants and adults without the codon 54 mutation were 1225 \u00b1701 ng\/ml (n = 45), 2064 \u00b1 829 ng\/ml (n= 88) and 2473 \u00b1 1395ng\/ml (n = 95), respectively; the corresponding values for those with the codon 54 mutation were 130 \u00b1275 ng\/ml (n= 18), 533 \u00b1665 ng\/ml (n = 35)and 330\u00b1225ng\/ ml (n= 28), respectively. Intra-uterine growth retardation in preterm infants does not influence MBP levels. For those without the codon 54 mutation, there is a significant difference in MBP level between the three age groups. For those with the codon 54 mutation, there is a significant difference between preterm and term infants, but not between term infants and adults. We conclude that there is a maturation in MBP levels for preterm infants, and that a moderately low MBP phenotype does not affect survival. We cannot exclude an effect of profoundly reduced MBP levels (characteristic of individuals homozygous for the codon 54 mutation), since no such preterm infant was identified in this study.<\/jats:p>","DOI":"10.1111\/j.1365-2249.1995.tb03866.x","type":"journal-article","created":{"date-parts":[[2010,7,26]],"date-time":"2010-07-26T19:36:15Z","timestamp":1280172975000},"page":"649-654","source":"Crossref","is-referenced-by-count":50,"title":["Mannose-binding protein in preterm infants: developmental profile and clinical significance"],"prefix":"10.1093","volume":"102","author":[{"given":"Y L","family":"Lau","sequence":"first","affiliation":[{"name":"Department of Paediatrics, The University of Hong Kong, Queen Mary Hospital, Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S Y","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, The University of Hong Kong, Queen Mary Hospital, Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M W","family":"Turner","sequence":"additional","affiliation":[{"name":"Molecular Immunology Unit, Institute of Child Health. University of London, London. UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Fong","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, The University of Hong Kong, Queen Mary Hospital, Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Karlberg","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, The University of Hong Kong, Queen Mary Hospital, Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2008,6,28]]},"reference":[{"key":"2022011518174536200_b1","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/0952-7915(93)90082-4","article-title":"Collectins: pattern recognition molecules involved in first line host defence","volume":"5","author":"Sastry","year":"1993","journal-title":"Curr Opin 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