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When monoclonal anti-SCF was administered intratracheally during allergen challenge there was a significant alteration of eosinophil accumulation and airway hyperreactivity (AHR). Anti-SCF treatment also attenuated pulmonary cytokine and chemokine levels. In particular, there was an antibody dose-dependent decrease in interleukin (IL)-5 and tumour necrosis factor (TNF)-\u03b1. There was also a significant reduction of CCL2 and CCL5, which correlated with the reduction in AHR. Mice treated with anti-SCF demonstrated a significant decrease in pulmonary gob-5 gene expression, which has been shown to correlate to goblet cell hyperplasia\/metaplasia relating to airway mucus production. Blocking SCF-mediated activation within the airway using a monoclonal antibody indicates that this cytokine may represent a viable target for therapeutic intervention that could affect multiple aspects of allergen-induced immunopathology.<\/jats:p>","DOI":"10.1111\/j.1365-2249.2004.02404.x","type":"journal-article","created":{"date-parts":[[2004,3,18]],"date-time":"2004-03-18T10:17:18Z","timestamp":1079605038000},"page":"15-20","source":"Crossref","is-referenced-by-count":25,"title":["Inhibition of stem cell factor reduces pulmonary cytokine levels during allergic airway responses"],"prefix":"10.1093","volume":"136","author":[{"given":"A A","family":"BERLIN","sequence":"first","affiliation":[{"name":"University of Michigan Medical School, Department of Pathology, Ann Arbor, MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"LINCOLN","sequence":"additional","affiliation":[{"name":"University of Michigan Medical School, Department of Pathology, Ann Arbor, MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"TOMKINSON","sequence":"additional","affiliation":[{"name":"Bayer Biotechnology, Berkley, CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N W","family":"LUKACS","sequence":"additional","affiliation":[{"name":"University of Michigan Medical School, Department of Pathology, Ann Arbor, MI"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2004,3,5]]},"reference":[{"key":"2022011223182582600_b1","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1152\/physrev.00020.2001","article-title":"Immunity, inflammation, and remodeling in the airway epithelial barrier: epithelial-viral-allergic paradigm","volume":"82","author":"Holtzman","year":"2002","journal-title":"Physiol Rev"},{"key":"2022011223182582600_b2","first-page":"81","article-title":"Effects of stem cell factor (SCF) on human marrow neutrophil, neutrophil\/macrophage mixed, macrophage and eosinophil progenitor cell growth","volume":"59","author":"Ichihara","year":"1994","journal-title":"Int J Hematol"},{"key":"2022011223182582600_b3","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1002\/stem.5530120411","article-title":"Stem cell factor enhances the survival of irradiated human bone marrow maintained in SCID mice","volume":"12","author":"Leigh","year":"1994","journal-title":"Stem Cells (Dayt)"},{"key":"2022011223182582600_b4","first-page":"965","article-title":"The c-kit receptor, stem cell factor, and mast cells. 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