{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T21:04:44Z","timestamp":1791493484252,"version":"4.3.4"},"reference-count":62,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2004,3,30]],"date-time":"2004-03-30T00:00:00Z","timestamp":1080604800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,3,30]]},"abstract":"<jats:title>SUMMARY<\/jats:title>\n                  <jats:p>We studied the autoantigen targets of 75 human sera that had antibodies to the nuclear envelope (NE) as identified by indirect immunofluorescence (IIF) on HEp-2 cells. Several different IIF staining patterns could be identified when antibodies to different components of the nuclear membrane (NM) and nuclear pore complexes (NuPC) were identified: a smooth membrane pattern characteristic of antibodies to nuclear lamins, a punctate pattern typical of antibodies to the nuclear pore complex and more complex patterns that included antibodies to nuclear and cytoplasmic organelles. Western immunoblotting of isolated nuclear and NE proteins and immunoprecipitation of radiolabelled recombinant proteins prepared by using the full-length cDNAs of the Translocated promoter region (Tpr), gp210 and p62 were used to identify specific autoantibody targets. Fifty-two of the 75 (70%) sera bound to Tpr, 25 (33%) bound to lamins A, B or C, 15 (20%) reacted with gp210 and none reacted with p62. Sixteen (21%) did not react with any of the NE components tested in our assays. The clinical features of 37 patients with anti-NE showed that there were 34 females and three males with an age range of 16\u201388\u2003years (mean 59\u2003years). The most frequent clinical diagnosis (9\/37\u2003=\u200324%) was autoimmune liver disease (ALD; two with primary biliary cirrhosis), followed by seven (19%) with systemic lupus erythematosus (SLE), four (11%) with a motor and\/or sensory neuropathy, three (8%) with anti-phospholipid syndrome (APS), two with systemic sclerosis (SSc), two with Sj\u00f6gren's syndrome (SjS), and others with a variety of diagnoses. This report indicates that Tpr, a component of the NuPC, is a common target of human autoantibodies that react with the NE.<\/jats:p>","DOI":"10.1111\/j.1365-2249.2004.02432.x","type":"journal-article","created":{"date-parts":[[2004,4,8]],"date-time":"2004-04-08T04:00:40Z","timestamp":1081396840000},"page":"379-387","source":"Crossref","is-referenced-by-count":32,"title":["The nuclear pore complex protein Tpr is a common autoantigen in sera that demonstrate nuclear envelope staining by indirect immunofluorescence"],"prefix":"10.1093","volume":"136","author":[{"given":"Y","family":"OU","sequence":"first","affiliation":[{"name":"Department of Anatomy and Cell Biology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"ENARSON","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cell Biology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J B","family":"RATTNER","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cell Biology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S G","family":"BARR","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Medicine, University of Calgary, Calgary, AB, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M J","family":"FRITZLER","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Medicine, University of Calgary, Calgary, AB, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2004,3,30]]},"reference":[{"key":"2022011223183961700_b1","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/B978-044482383-0\/50024-8","volume-title":"Autoantibodies","author":"Rattner","year":"1996"},{"key":"2022011223183961700_b2","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1023\/A:1020551610319","article-title":"Centrosome proteins: a major class of autoantigens in scleroderma","volume":"19","author":"Gavanescu","year":"1999","journal-title":"J Clin Immunol"},{"key":"2022011223183961700_b3","doi-asserted-by":"crossref","first-page":"138","DOI":"10.3181\/00379727-204-43645","article-title":"Autoantibodies as probes in cell and molecular biology","volume":"204","author":"Balczon","year":"1993","journal-title":"Proc Soc Exp Biol Med"},{"key":"2022011223183961700_b4","doi-asserted-by":"crossref","first-page":"13503","DOI":"10.1074\/jbc.270.22.13503","article-title":"EEA1, an early endosomal protein","volume":"270","author":"Mu","year":"1995","journal-title":"J Biol Chem"},{"key":"2022011223183961700_b5","first-page":"311","article-title":"Early endosome antigen 1: an autoantigen associated with neurological diseases","volume":"47","author":"Selak","year":"1999","journal-title":"J Invest Med"},{"key":"2022011223183961700_b6","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1084\/jem.181.2.585","article-title":"A novel class of autoantigens of anti-neutrophil cytoplasmic antibodies in necrotizing and crescentic glomerulonephritis: the lysosomal membrane glycoprotein h-lamp-2 in neutrophil granulocytes and a related membrane protein in glomerular endothelial cells","volume":"181","author":"Kain","year":"1995","journal-title":"J Exp Med"},{"key":"2022011223183961700_b7","first-page":"85","volume-title":"Pathogenic and diagnostic relevance of autoantibodies. 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