{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T08:28:36Z","timestamp":1777710516860,"version":"3.51.4"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2004,5,4]],"date-time":"2004-05-04T00:00:00Z","timestamp":1083628800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,5,4]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>Human T lymphotrophic virus type-I (HTLV-I), a human retrovirus, infects CD4+ lymphocytes and is thought to modify their function and a possible association with pulmonary diseases has also been suggested. However, little is known about the influence of HTLV-I on diffuse pan-bronchiolitis (DPB), a chronic inflammatory lung disease with infiltration of lymphocytes and hyperplasia of the bronchus-associated lymphoid tissue. In this study, 35 DPB patients with and without HTLV-I infection were examined. HTLV-I positive DPB patients were likely to have a larger affected area with lower FEV1. The CD3+\/CD25+ lymphocyte percentage was significantly higher in the BALF of HTLV-I positive patients than in negative patients. MIP-1\u03b1, IP-10 and levels in BALF were also significantly higher in HTLV-I positive patients than in negative patients. The levels of MCP-1 and IL-8 were not significantly different. In HTLV-I positive patients, the MIP-1\u03b1 and IP-10 levels showed a significant positive correlation with the percentage of CD3+\/CD25 lymphocytes. BALF cells of all HTLV-I positive DPB patients showed expression of p40tax mRNA. We suggest that HTLV-I infection may modify DPB pathogenesis via activation of T cells. We also found that the frequency of ATL development in HTLV-I positive DPB patients was significantly higher than in all HTLV-I positive patients (OR\u2003=\u20038\u00b722, 95% CI\u2003=\u20032\u00b761\u201325\u00b79, P\u2003&amp;lt;\u20030\u00b701). The levels of TGF-\u03b2 in patients who developed ATL were significantly lower than in patients who did not develop ATL. Sensitivity and specificity were 80% and 85\u00b77%, respectively (cut-off\u2003=\u200320\u2003pg\/ml). We also propose that these features should be taken into consideration in the treatment of DPB in HTLV-I infected individuals.<\/jats:p>","DOI":"10.1111\/j.1365-2249.2004.02485.x","type":"journal-article","created":{"date-parts":[[2004,5,14]],"date-time":"2004-05-14T14:46:12Z","timestamp":1084545972000},"page":"513-520","source":"Crossref","is-referenced-by-count":13,"title":["Influence of human T lymphotrophic virus type I on diffuse pan-bronchiolitis"],"prefix":"10.1093","volume":"136","author":[{"given":"M","family":"YAMAMOTO","sequence":"first","affiliation":[{"name":"Third Department of Internal Medicine, Kagoshima University Faculty of Medicine, Kagoshima, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W","family":"MATSUYAMA","sequence":"additional","affiliation":[{"name":"Third Department of Internal Medicine, Kagoshima University Faculty of Medicine, Kagoshima, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"OONAKAHARA","sequence":"additional","affiliation":[{"name":"Third Department of Internal Medicine, Kagoshima University Faculty of Medicine, Kagoshima, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"WATANABE","sequence":"additional","affiliation":[{"name":"Third Department of Internal Medicine, Kagoshima University Faculty of Medicine, Kagoshima, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I","family":"HIGASHIMOTO","sequence":"additional","affiliation":[{"name":"Third Department of Internal Medicine, Kagoshima University Faculty of Medicine, Kagoshima, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"KAWABATA","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, National Minami-kyushu Hospital, Kagoshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"OSAME","sequence":"additional","affiliation":[{"name":"Third Department of Internal Medicine, Kagoshima University Faculty of Medicine, Kagoshima, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"ARIMURA","sequence":"additional","affiliation":[{"name":"Third Department of Internal Medicine, Kagoshima University Faculty of Medicine, Kagoshima, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2004,5,5]]},"reference":[{"key":"2022011223182074800_b1","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1378\/chest.83.1.63","article-title":"Diffuse panbronchiolitis. 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