{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T19:23:05Z","timestamp":1791141785360,"version":"4.1.0"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2004,7,23]],"date-time":"2004-07-23T00:00:00Z","timestamp":1090540800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,7,23]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>The objective of this study was to determine the diagnostic and prognostic values of antiglucose-6-phosphate isomerase (GPI) antibodies in patients with very early arthritis. Anti-GPI antibodies were measured by ELISA using purified GPI from rabbit muscle in: (i) 383 sera from healthy blood donors (n\u2003=\u2003120), well-established rheumatoid arthritis (RA) (n\u2003=\u200399) and non-RA differentiated arthritis (NRADA) (n\u2003=\u2003164) patients; (ii) 195 sera obtained from community-recruited patients with very early inflammatory arthritis (VErA cohort) that were studied for 1\u2003year and classified as having RA (n\u2003=\u2003116), NRADA (n\u2003=\u200341), and undifferentiated arthritis (UA) (n\u2003=\u200338) after the follow-up period. The criterion for severity was the progression of radiographic damage. Prevalence of anti-GPI antibodies was significantly higher in well-established RA patients (45\u00b74%) compared to healthy subjects (2\u00b75%). Anti-GPI antibodies were also present in sera from NRADA: systemic lupus erythematosus 53%, polymyositis 45\u00b74%, adult-onset Still's disease 44%, systemic sclerosis 42\u00b78%, spondylarthropathies 25% and primary Sj\u00f6gren\u2019s syndrome 5\u00b78%. No significant association was found between the presence of anti-GPI antibodies and the 3 diagnostic groups from the VErA cohort. No correlation was observed between anti-GPI and autoantibodies usually associated with RA. Anti-GPI antibodies were not predictive of radiological progression in patients with very early arthritis. Thus, anti-GPI antibodies are not useful for discriminating RA from non-RA rheumatic diseases and do not constitute a predictive factor of structural damage.<\/jats:p>","DOI":"10.1111\/j.1365-2249.2004.02552.x","type":"journal-article","created":{"date-parts":[[2004,8,20]],"date-time":"2004-08-20T10:57:27Z","timestamp":1092999447000},"page":"606-611","source":"Crossref","is-referenced-by-count":16,"title":["Diagnostic and prognostic values of anti glucose-6-phosphate isomerase antibodies in community-recruited patients with very early arthritis"],"prefix":"10.1093","volume":"137","author":[{"given":"F","family":"JOUEN","sequence":"first","affiliation":[{"name":"INSERM 519, Institut F\u00e9d\u00e9ratif de Recherche Multidisciplinaire sur les Peptides (IFR MP 23), Facult\u00e9 de M\u00e9decine et de Pharmacie, Rouen"},{"name":"Laboratoire d'immunopatholologie and Services 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