{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T07:44:38Z","timestamp":1772696678955,"version":"3.50.1"},"reference-count":45,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2004,9,29]],"date-time":"2004-09-29T00:00:00Z","timestamp":1096416000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,10,7]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>There is accumulating evidence that haem oxygenase (HO)-1 plays a protective role in various disorders. The beneficial efficacy of HO-1 induction therapy has been shown in renal diseases such as glomerulonephritis, interstitial nephritis and drug induced nephrotoxicity. However, involvement of HO-1 in the development of autoimmune renal diseases remains uncertain. To assess the clinical efficacy of HO-1 induction therapy for lupus glomerulonephritis, MRL\/lpr mice were intraperitoneally injected with 100\u2003\u00b5mol\/kg hemin, a potent HO-1 inducer, or PBS as controls, once a week from 6\u2003weeks of age to 21\u201324\u2003weeks-old. We found that treatment with hemin led to a significant reduction of proteinuria and remarkable amelioration of glomerular lesions accompanied by decreased immune depositions. In addition, the circulating IgG anti-double-stranded DNA antibody level was significantly decreased in hemin treated mice when compared with controls. A single intraperitoneal injection with hemin resulted in reduction of inducible nitric oxide synthase expression in the kidney and spleen, and serum interferon-\u03b3 level. Our results suggest that HO-1 induction therapy ameliorates lupus nephritis by suppressing nitric oxide (NO) dependent inflammatory responses and attenuating production of pathogenic autoantibodies.<\/jats:p>","DOI":"10.1111\/j.1365-2249.2004.02594.x","type":"journal-article","created":{"date-parts":[[2004,10,20]],"date-time":"2004-10-20T11:44:23Z","timestamp":1098272663000},"page":"237-244","source":"Crossref","is-referenced-by-count":59,"title":["Chemical induction of HO-1 suppresses lupus nephritis by reducing local<i>i<\/i>NOS expression and synthesis of anti-dsDNA antibody"],"prefix":"10.1093","volume":"138","author":[{"given":"Y","family":"TAKEDA","sequence":"first","affiliation":[{"name":"Yokohama City University Graduate School of Medicine, Department of Internal Medicine and Clinical Immunology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"TAKENO","sequence":"additional","affiliation":[{"name":"Yokohama City University Graduate School of Medicine, Department of Internal Medicine and Clinical Immunology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"IWASAKI","sequence":"additional","affiliation":[{"name":"Yokohama City University Graduate School of Medicine, Department of Internal Medicine and Clinical Immunology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"KOBAYASHI","sequence":"additional","affiliation":[{"name":"Yokohama City University Graduate School of Medicine, Department of Internal Medicine and Clinical Immunology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"KIRINO","sequence":"additional","affiliation":[{"name":"Yokohama City University Graduate School of Medicine, Department of Internal Medicine and Clinical Immunology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"UEDA","sequence":"additional","affiliation":[{"name":"Yokohama City University Graduate School of Medicine, Department 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